首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   31374篇
  免费   36篇
  国内免费   69篇
系统科学   162篇
丛书文集   717篇
教育与普及   79篇
理论与方法论   200篇
现状及发展   13501篇
研究方法   1347篇
综合类   15104篇
自然研究   369篇
  2013年   174篇
  2012年   419篇
  2011年   832篇
  2010年   180篇
  2008年   552篇
  2007年   539篇
  2006年   596篇
  2005年   591篇
  2004年   517篇
  2003年   567篇
  2002年   566篇
  2001年   978篇
  2000年   896篇
  1999年   598篇
  1992年   569篇
  1991年   462篇
  1990年   486篇
  1989年   489篇
  1988年   490篇
  1987年   498篇
  1986年   490篇
  1985年   599篇
  1984年   494篇
  1983年   404篇
  1982年   346篇
  1981年   340篇
  1980年   448篇
  1979年   967篇
  1978年   855篇
  1977年   846篇
  1976年   580篇
  1975年   630篇
  1974年   931篇
  1973年   785篇
  1972年   804篇
  1971年   1017篇
  1970年   1339篇
  1969年   1004篇
  1968年   945篇
  1967年   988篇
  1966年   829篇
  1965年   609篇
  1964年   148篇
  1959年   360篇
  1958年   522篇
  1957年   443篇
  1956年   366篇
  1955年   316篇
  1954年   363篇
  1948年   193篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
911.
Summary After 7 days of space flight house flies,Musca domestica, exhibited similar longevity, but a reduction in reproductive output as compared to earthbound controls. This reduction was not observed in later generations. These data suggest that space flight directly alters the rate of ovarian development, but that this effect is not genetically transmitted.Acknowledgment. We thank Todd E. Nelson, student participant in the Space Shuttle Student Involvement Project, John T. Jackson, NASA/Johnson Space Center, and James R. Peterson, Honeywell, Inc. for providing us with the flies and information related to the in-flight experiments.  相似文献   
912.
Summary One of two cases of acquired immune deficiency syndrome-related persistent generalized lymphadenopathy revealed a profoundly altered pattern of dendritic reticulum cells as demonstrated by immunoreactive acid cysteine proteinase inhibitor. The alterations could be related to totally or partially destructed lymphoid secondary follicles.Acknowledgments. This work has been partially supported by the grant from the Sigrid Juselius Foundation, Finland.  相似文献   
913.
Indoxyl derivatives were detected as minor products among the urinary metabolites of two trial drugs, a benzodiazepine (GP 55 129) and a benzophenone (CGP 11 952). Their structures were elucidated by NMR and mass spectroscopy. Presumably, metabolites containing potential aldehyde functions react spontaneously with endogenous indoxyl. Such derivatives have not hitherto been encountered in drug metabolism.  相似文献   
914.
Summary A novel glycoprotein was isolated from the endometrium of porcine uteri. This high-molecular-weight glycoprotein consisted of 25% of protein and 73% of carbohydrate. The carbohydrate composition was quite characteristic in that equimolar N-acetylglucosamine and galactose were major constituents. Its unique nature makes it distinguishable from hitherto-reported glycoproteins.  相似文献   
915.
L Mercken  M J Simons  S Swillens  M Massaer  G Vassart 《Nature》1985,316(6029):647-651
In mammals, an adequate supply of thyroid hormones is essential for normal growth and neurological development. The biosynthesis of thyroid hormones involves an iodinated precursor protein, thyroglobulin, which may be considered an extreme example of a pro-hormone. Thyroglobulin is a dimeric glycoprotein of relative molecular mass (Mr) 660,000 (660K), which is secreted by the thyrocyte and stored in the lumen of the thyroid follicle. The hormonogenic reaction is extracellular, and involves iodination of tyrosyl residues of thyroglobulin and the intramolecular coupling of a subset of these into thyroxine (T4) and triiodothyronine (T3), which remain part of the polypeptide chain. Secretion of hormones results from the endocytosis of thyroglobulin followed by its complete hydrolysis in lysosomes. Considering that the maximum yield of hormones is approximately 6-8 per 660K protein, the whole process is apparently wasteful. However, the efficiency of thyroglobulin as a thyroid hormone precursor is extremely high when the supply of iodine is short; in such conditions, almost all the iodine incorporated is found in iodothyronine. Hence it is suggested that the thyroglobulin structure has evolved to allow for the preferential and efficient iodination and coupling of the hormonogenic tyrosines. Here we report the complete primary structure of bovine thyroglobulin, derived from the sequence of its 8,431-base-pair complementary DNA. The 2,769-amino-acid sequence is characterized by a pattern of imperfect repeats derived from three cysteine-rich motifs. Four hormonogenic tyrosines have been precisely localized near the amino and carboxyl ends of the protein.  相似文献   
916.
917.
Summary In gerbil adrenal cortex the activity of intramitochondrial NADP-linked isocitric dehydrogenase (IDH) is up to 10-fold greater than the NAD-linked IDH. The NADP-IDH, apparent Km 0.58 mM, Vmax 280 nmoles/min/mg mitochondrial protein, appears to be the major source of reducing equivalents to support adrenal mitochondrial steroid 11B- and 19-hydroxylation in this species.  相似文献   
918.
Summary A thiol:protein disulfide oxidoreductase from bovine liver was isolated after separation from protein disulfide isomerase. The enzyme, after activation (reduction) with glutathione, was reacted with stoichiometric amounts of insulin and the sulfhydryl groups of the partially reduced hormone were labeled with iodo (l-14C)acetamide. After separation of the insulin chains, the radioactivity was found in both the peptides, with a ratio A-chain/B-chain equal to 2/1.  相似文献   
919.
Summary Lactate dehydrogenase zymograms of mature testes ofHymenochirus boettgeri show in addition to the five isozymes composed of LDH-A and LDH-B subunits, a second 5-band system which is due to isozymes formed between LDH-A and a third subunit, LDH-C. These testis-specific LDH-C isozymes appear around 6 months after metamorphosis indicating that their expression is correlated with sexual maturity as is generally the case in mammals. This is the first report of a testis-specific LDH isozyme in a lower tetrapod; such isozymes have hitherto only been reported in mammals and in the pigeon.This study was supported by a grant from the Fond National Suisse de la Recherche Scientifique to H.R.K. We thank M. Sateur and F. Bourquin for their technical help.  相似文献   
920.
The developing urogenital complex of the fetal mouse was studied by means of silver impregnation and electron microscopy. These studies showed that: 1) the mesonephric field is innervated during prenatal stages (Wolffian nerve); 2) nerve penetration precedes the differentiation of the gonads and related ducts; and 3) the Wolffian nerve arises during the earliest stages from the first pair of abdominal rami communicantes. The identity between the fetal Wolffian nerve and the nerve of the suspensory ligament (higher pathway) of the adult is discussed.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号