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851.
供应链中电子市场与合约市场的协调研究 总被引:14,自引:0,他引:14
供应链的供求关系可以建立在两个不同的交易方式上,一种是通过电子市场,另一种是通过合约市场.这两种交易方式各有其优缺点,电子市场具有灵活性,但缺乏稳定性,合约市场则相反.为了使供应商与制造商能够充分利用电子市场与合约市场的优点,设计了一种以期权合约为基础的协调机制,并且利用期权的思想,求出了在这种协调机制下供应商与制造商的最优策略. 相似文献
852.
Pt nanoparticles were prepared by the chemical reduction method.The average diameter of Pt nanoparticles was determined to be 2.5nm by TEM.The electrochemical propertis of Pt nanoparticles were studied by cyclic voltammetry,In comparison with massive Pt,the oxidation current peak of CO adsorbed on Pt nanoparticles in broader.Twin adsorbates of CO on Pt nanoparticles were determined by in situ FTIRS for the first time.It has revealed that the linear and twin-bonded CO can be converted into bridge-bonded CO with the variation of electrode potential.A series of special properties of Pt nanoparticles,such as enhanced IR absorption of CO adsorbates,were also observed. 相似文献
853.
着重研究了二值点阵图像的放大、缩小方法,针对二值点阵灰度图和工程图现有的缩小和放大算法及存在的问题,提出了基于区域特征的图像变换思想,以图块为单位进行图像的放大、缩小.据此,提出了对二值灰度图和工程图进行放大、缩小的改进算法并进行分析。 相似文献
854.
采用直流反应磁控溅射方法在304不锈钢表面沉积TiN薄膜.利用场发射扫描电镜、X射线衍射仪和纳米压痕仪研究基体温度对TiN薄膜结构与性能的影响.结果表明:TiN薄膜为柱状结构,表面平整、致密.薄膜为面心立方结构(fcc)TiN并存在择优取向,室温和150℃时薄膜为(111)晶面择优取向,300和450℃时薄膜为(200)晶面择优取向;室温时薄膜厚度仅为0.63μm,加温到150℃后膜厚增加到1μm左右,但继续加温对膜厚影响不明显;平均晶粒尺寸随着基体温度的升高略有上升;薄膜的硬度、弹性模量和韧性(H3/E*2)随基体温度的升高而增加,最值分别达到25.4,289.4和0.1744GPa. 相似文献
855.
应用马尔可夫理论对市场进行预测与决策 总被引:5,自引:0,他引:5
阐述了马尔可夫决策理论中的最基本分析方法——系统状态转移概率矩阵决策法 ,指出这种决策分析法能有效地对市场作出预测与决策 ,特别对于某些预测问题 ,应用此法的效果比用其他一些经典预测法所得的结果更优 .对美国柯达、日本富士、中国乐凯三家公司的产品占有率进行了预测与决策 相似文献
856.
关于建立区域施工平面控制网几个问题的探讨 总被引:1,自引:0,他引:1
文中就施工平面控制网的等级确定 ,以及如何选择合适的高程抵偿面使投影变形值最小 ,进行细致的分析与探讨 ,总结出各类工程建筑限差与拟建网的精度配比关系 ,推证出最佳抵偿高程面之高程 ,对于工程建网具有一定的指导意义。 相似文献
857.
Cadmium is a mutagen that acts by inhibiting mismatch repair 总被引:27,自引:0,他引:27
Jin YH Clark AB Slebos RJ Al-Refai H Taylor JA Kunkel TA Resnick MA Gordenin DA 《Nature genetics》2003,34(3):326-329
Most errors that arise during DNA replication can be corrected by DNA polymerase proofreading or by post-replication mismatch repair (MMR). Inactivation of both mutation-avoidance systems results in extremely high mutability that can lead to error catastrophe. High mutability and the likelihood of cancer can be caused by mutations and epigenetic changes that reduce MMR. Hypermutability can also be caused by external factors that directly inhibit MMR. Identifying such factors has important implications for understanding the role of the environment in genome stability. We found that chronic exposure of yeast to environmentally relevant concentrations of cadmium, a known human carcinogen, can result in extreme hypermutability. The mutation specificity along with responses in proofreading-deficient and MMR-deficient mutants indicate that cadmium reduces the capacity for MMR of small misalignments and base-base mismatches. In extracts of human cells, cadmium inhibited at least one step leading to mismatch removal. Together, our data show that a high level of genetic instability can result from environmental impediment of a mutation-avoidance system. 相似文献
858.
Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. 总被引:36,自引:0,他引:36
A Brazma P Hingamp J Quackenbush G Sherlock P Spellman C Stoeckert J Aach W Ansorge C A Ball H C Causton T Gaasterland P Glenisson F C Holstege I F Kim V Markowitz J C Matese H Parkinson A Robinson U Sarkans S Schulze-Kremer J Stewart R Taylor J Vilo M Vingron 《Nature genetics》2001,29(4):365-371
Microarray analysis has become a widely used tool for the generation of gene expression data on a genomic scale. Although many significant results have been derived from microarray studies, one limitation has been the lack of standards for presenting and exchanging such data. Here we present a proposal, the Minimum Information About a Microarray Experiment (MIAME), that describes the minimum information required to ensure that microarray data can be easily interpreted and that results derived from its analysis can be independently verified. The ultimate goal of this work is to establish a standard for recording and reporting microarray-based gene expression data, which will in turn facilitate the establishment of databases and public repositories and enable the development of data analysis tools. With respect to MIAME, we concentrate on defining the content and structure of the necessary information rather than the technical format for capturing it. 相似文献
859.
Receptive field plasticity of neurons in rat auditory cortex 总被引:2,自引:0,他引:2
YANGWenwei GAOLixia SUNXinde 《科学通报(英文版)》2004,49(13):1364-1369
Using conventional electrophysiological technique, we investigated the plasticity of the frequency receptive fields (RF) of auditory cortex (AC) neurons in rats. In the AC, when the frequency difference between conditioning stimulus frequency (CSF) and the best frequency (BF) was in the range of 1--4 kHz, the frequency RF of AC neurons shifted. The smaller the differences between CSF and BF, the higher the probability of the RF shift and the greater the degree of the RF shift. To some extent, the plasticity of RF was dependent on the duration of the session of conditioning stimulus (CS). When the frequency difference between CSF and BF was bigger, the duration of the CS session needed to induce the plasticity was longer. The recovery time course of the frequency RF showed opposite changes after CS cessation.The RF shift could be induced by the frequency that was either higher or lower than the control BF, demonstrating no clear directional preference. The frequency RF of some neurons showed bidirectional shift, and the RF of other neurons showed single directional shift. The results suggest that the frequency RF plasticity of AC neurons could be considered asan ideal model for studying plasticity mechanism. The present study also provides important evidence for further study of learning and memory in auditory system. 相似文献
860.
Chiang C Jacobsen JC Ernst C Hanscom C Heilbut A Blumenthal I Mills RE Kirby A Lindgren AM Rudiger SR McLaughlan CJ Bawden CS Reid SJ Faull RL Snell RG Hall IM Shen Y Ohsumi TK Borowsky ML Daly MJ Lee C Morton CC MacDonald ME Gusella JF Talkowski ME 《Nature genetics》2012,44(4):390-7, S1
We defined the genetic landscape of balanced chromosomal rearrangements at nucleotide resolution by sequencing 141 breakpoints from cytogenetically interpreted translocations and inversions. We confirm that the recently described phenomenon of 'chromothripsis' (massive chromosomal shattering and reorganization) is not unique to cancer cells but also occurs in the germline, where it can resolve to a relatively balanced state with frequent inversions. We detected a high incidence of complex rearrangements (19.2%) and substantially less reliance on microhomology (31%) than previously observed in benign copy-number variants (CNVs). We compared these results to experimentally generated DNA breakage-repair by sequencing seven transgenic animals, revealing extensive rearrangement of the transgene and host genome with similar complexity to human germline alterations. Inversion was the most common rearrangement, suggesting that a combined mechanism involving template switching and non-homologous repair mediates the formation of balanced complex rearrangements that are viable, stably replicated and transmitted unaltered to subsequent generations. 相似文献