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61.
大豆蛋白质的泡沫分离研究 I.操作工艺条件 总被引:1,自引:0,他引:1
在一连续操作的泡沫精馏塔中,考察了各种操作条件对大豆蛋白质溶液泡沫分离过程的影响,包括:进料浓度、进气流量、pH值、回流比等,确定了较佳的操作条件。用流动法测定了大豆蛋白质在气液界面上的表面过剩浓度并回归了线性吸附方程。结果表明:在溶液浓度较稀时,表面过剩浓度与溶液浓度呈线性关系。 相似文献
62.
采用球面刀在三坐标数控机床上加工具有凸曲面工位的零部件时,往往会导致几何形状误差,对此,运用点涉法原理,推导出在凸曲面上确定平头立铣刀五轴和三轴数控联动加工刀位轨迹的计算方法。 相似文献
63.
Stem cells, cancer, and cancer stem cells. 总被引:312,自引:0,他引:312
Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine. Perhaps the most important and useful property of stem cells is that of self-renewal. Through this property, striking parallels can be found between stem cells and cancer cells: tumours may often originate from the transformation of normal stem cells, similar signalling pathways may regulate self-renewal in stem cells and cancer cells, and cancer cells may include 'cancer stem cells' - rare cells with indefinite potential for self-renewal that drive tumorigenesis. 相似文献
64.
通过测定,得出马来酸酐改性聚丙烯(MPP)是提高玻璃纤维与聚丙烯树脂界面剪切强度的关键因素,而偶联剂的变化对体系界面剪切强度的影响较少,用仪器分析证实了酸酐基团与玻璃纤维表面发生化学反应的实质,以及当界面存在改性聚丙烯时,应选择A-174TM硅烷偶联剂处理增强聚丙烯的玻璃纤维,而不是传统的A-1100TM硅烷偶联剂。 相似文献
65.
66.
67.
Crnković-Mertens I Wagener N Semzow J Gröne EF Haferkamp A Hohenfellner M Butz K Hoppe-Seyler F 《Cellular and molecular life sciences : CMLS》2007,64(9):1137-1144
Cancer cells are typically characterized by apoptosis deficiency. In order to investigate a possible role for the anti-apoptotic
livin gene in renal cell cancer (RCC), we analyzed its expression in tumor tissue samples and in RCC-derived cell lines. In addition,
we studied the contribution of livin to the apoptotic resistance of RCC cells by RNA interference (RNAi). Livin gene expression was detected in a significant portion of RCC tumor tissue specimens (13/14, 92.9%) and tumor-derived cell
lines (12/15, 80.0%). Moreover, targeted inhibition of livin by RNAi markedly sensitized RCC cells towards proapoptotic stimuli, such as UV irradiation or the chemotherapeutic drugs
etoposide, 5-fluorouracil, and vinblastine. These effects were specific for livin expressing tumor cells. We conclude that livin can contribute significantly to the apoptosis resistance of RCC cells. Targeted inhibition of livin could represent a novel therapeutic strategy to increase the sensitivity of renal cancers towards pro-apoptotic agents.
Received 30 November 2006; received after revision 22 February 2007; accepted 20 March 2007 相似文献
68.
Alzheimer disease (AD), while chronic and progressive with an average progression of 7 – 10 years, is both multifactorial
and heterogeneous. Thus, AD offers a large window of opportunity and a large number of therapeutic targets to inhibit it.
The selection of a therapeutic target, however, is one of the biggest challenges in developing a pharmacological treatment
of this multifactorial disease. Inhibition of a pivotal downstream event is likely to benefit more patients than inhibition
of an upstream event in AD pathogenesis. Neurofibrillary degeneration of abnormally hyperphosphorylated tau offers such a
pivotal therapeutic target. Abnormal hyperphosphorylation of tau and not its aggregation into filaments appears to be the
most deleterious step in neurofibrillary degeneration. Tau can be abnormally hyperphosphorylated by downregulation of protein
phosphatase-2A activity or by upregulation of more than one tau kinase. Restoration of the phosphatase activity which is downregulated
in AD brain or inhibition of GSK-3β and cdk5, which are required for AD-type abnormal hyperphosphorylation of tau, are among
the most promising therapeutic strategies. 相似文献
69.
The RecQ family of DNA helicases is highly conserved throughout evolution and plays an important role in the maintenance of
genomic stability in all organisms. Mutations in three of the five known family members in humans, BLM, WRN and RECQL4, give rise to disorders that are characterized by predisposition to cancer and premature aging, emphasizing the importance
of studying the RecQ proteins and their cellular activities. Interestingly, three autosomal recessive disorders have been
associated with mutations in the RECQL4 gene: Rothmund-Thomson, RAPADILINO, and Baller-Gerold syndromes, thus making RECQL4 unique within the RecQ family of DNA
helicases. To date, however, the molecular function of RECQL4 and the possible cellular pathways in which it is involved remain
poorly understood. Here, we present an overview of recent findings in connection with RECQL4 and try to highlight different
directions the field could head, helping to clarify the role of RECQL4 in preventing tumorigenesis and maintenance of genome
integrity in humans.
Received 31 October 2006; received after revision 4 January 2007; accepted 5 February 2007 相似文献
70.
The computational prediction of gene and protein function is rapidly gaining ground as a central undertaking in computational biology. Making sense of the flood of genomic data requires fast and reliable annotation. Many ingenious algorithms have been devised to infer a protein's function from its amino acid sequence, 3D structure and chromosomal location of the encoding genes. However, there are significant challenges in assessing how well these programs perform. In this article we explore those challenges and review our own attempt at assessing the performance of those programs. We conclude that the task is far from complete and that a critical assessment of the performance of function prediction programs is necessary to make true progress in computational function prediction. 相似文献