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991.
Soft Systems Methodology is especially useful in diagnosing and addressing organizational problems and designing new systems
in cultures that are characterised by pluralistic views and values. This paper demonstrates how SSM workshops in a large government
agency resulted in a high level of creativity. SSM is then proposed as a methodology that could enhance group creativity in
organizational design contexts. 相似文献
992.
Frank Stowell 《Systemic Practice and Action Research》2007,20(5):413-427
Increasingly knowledge has become a determining factor in achieving life’s potential and is the currency of the age. Without
access to Information an individuals’ knowledge base cannot be enriched and without knowledge the individual becomes increasingly
powerless. Advances in technology have provided opportunities for some to add to their stock of knowledge but access to sources
of information is uneven and can lead to social unrest. The availability of information is an important factor in managing
change and empowering citizens. The question about information and power then becomes one of ownership or sovereignty of the
information. If we are to create an open society then we need to ensure that there is open access to knowledge through flexible
and intelligent information systems that are available for all. In this paper we consider if we are truly entering the knowledge
age or the age of ignorance. 相似文献
993.
LIANG Yan ZUO JianRu YANG WeiCai 《科学通报(英文版)》2007,52(13):1729-1733
Arabidopsis thaliana, a model plant species, has a number of advantages over other plant species as an experimental organism due to many of its genetic and genomic features. The Chinese Arabidopsis community has made significant contributions to plant biology research in recent years[1,2]. In 2006, studies of plant biology in China received more attention than ever before, especially those pertaining to Arabidopsis research. Here we briefly summarize recent advances in Arabidopsis re-search in China. 相似文献
994.
LU Zhengding WEN Zhumu TANG Zhuo LI Ruixuan 《武汉大学学报:自然科学英文版》2007,12(5):955-960
This paper proposes a method to formalize the interoperation in multi-domain environment. Through employing the algebra method, we conclude four types of the conflicts for the interoperation, and analyzes the cause of the policy conflicts. For each type of conflicts, we formalize it and proposes the method of detection and resolution. Finally, the method is illuminated be effective through comparing our work with others. 相似文献
995.
I. Kubo T. Matsumoto F. J. Hanke M. Taniguchi Y. Hayashi 《Cellular and molecular life sciences : CMLS》1985,41(11):1462-1463
Summary A possible new role for the flavonoid (–)-epicatechin (II) is described. It has no growth effects on its own, but when it is added to lettuce and rice seeds together with the known seedling growth inhibitor nagilactone E (I), the growth inhibitor activity ofI can cease and growth stimulation can be observed. 相似文献
996.
There is considerable evidence that cyclic AMP can modulate the electrical activity of excitable cells and that protein phosphorylation by the catalytic subunit (CS) of cAMP-dependent protein kinase is a necessary step in these modulatory effects. In analogy to alterations in enzyme activities following phosphorylation, it seems possible that direct phosphorylation of ion-channel proteins may alter their gating properties, giving rise to the observe changes in electrical activity. However, the results obtained so far do not indicate whether it is ion channels themselves that are phosphorylated, or whether phosphorylation is simply an early step in some cascade of events which leads ultimately to modulation of channel activity. The development of single-channel recording techniques has provided a way to investigate this question. Here we describe effects of CS on the activity of individual CA2+-dependent K+ channels from the nervous system of the land snail Helix measured in isolated membrane patches and in artificial phospholipid bilayers. The results demonstrate that cAMP-dependent protein phosphorylation produces long-lasting changes in the activity of individual channels, and indicate that the relevant phosphorylation site is closely associated with the channel. 相似文献
997.
Hair cells in the mammalian cochlea transduce mechanical stimuli into electrical signals leading to excitation of auditory nerve fibres. Because of their important role in hearing, these cells are a possible site for the loss of cochlear sensitivity that follows acoustic overstimulation. We have recorded from inner and outer hair cells (IHC, OHC) in the guinea pig cochlea during and after exposure to intense tones. Our results show functional changes in the hair cells that may explain the origin of noise-induced hearing loss. Both populations of hair cells show a reduction in amplitude and an increase in the symmetry of their acoustically evoked receptor potentials. In addition, the OHCs also suffer a sustained depolarization of the membrane potential. Significantly, the membrane and receptor potentials of the OHCs recover in parallel with cochlear sensitivity as measured by the IHC receptor potential amplitude and the auditory nerve threshold. Current theories of acoustic transduction suggest that the mechanical input to IHCs may be regulated by the OHCs. Consequently, the modified function of OHCs after acoustic overstimulation may determine the extent of the hearing loss following loud sound. 相似文献
998.
Sulfhydryl compounds such as reduced glutathione, cysteine and 2-mercaptopropionylglycine, a hepato-protective agent, activated Cu, Zn-superoxide dismutase purified from rat liver at low concentrations (below 10 microM). Furthermore we found evidence indicating that this activation is achieved by reducing Cu2+ present in the catalytic site of the dismutase, and thereby promoting the dismutation of superoxide anions. 相似文献
999.
1000.
I A Macdonald 《Experientia》1978,34(4):426-427
Tritium distribution on randomly labelled taurocholate (TC) was estimated at 28%, 4%, 1% and less than 0.5% on the hydrogens opposite the 3alpha-, 7alpha- and 12alpha-OH groups and taurine moiety respectively. Anomalously, C. perfringens 3alpha-hydroxysteroid dehydrogenase (3alpha-HSDH) catalyzed tritium loss of 36% on formation of 7alpha-, 12alpha-dihydroxy-3-keto-5beta-cholanoate, implying additional losses of tritium at other sites by this enzyme. 相似文献