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91.
In addition to delivering a haploid genome to the egg, sperm have additional critical functions, including egg activation, origination of the zygote centrosome and delivery of paternal factors. Despite this, existing knowledge of the molecular basis of sperm form and function is limited. We used whole-sperm mass spectrometry to identify 381 proteins of the Drosophila melanogaster sperm proteome (DmSP). This approach identified mitochondrial, metabolic and cytoskeletal proteins, in addition to several new functional categories. We also observed nonrandom genomic clustering of sperm genes and underrepresentation on the X chromosome. Identification of widespread functional constraint on the proteome indicates that sexual selection has had a limited role in the overall evolution of D. melanogaster sperm. The relevance of the DmSP to the study of mammalian sperm function and fertilization mechanisms is demonstrated by the identification of substantial homology between the DmSP and proteins of the mouse axoneme accessory structure. 相似文献
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Cadwell K Liu JY Brown SL Miyoshi H Loh J Lennerz JK Kishi C Kc W Carrero JA Hunt S Stone CD Brunt EM Xavier RJ Sleckman BP Li E Mizushima N Stappenbeck TS Virgin HW 《Nature》2008,456(7219):259-263
94.
TMV RNA is not an efficient template for translation of the viral coat protein, in spite of containing nucleotide sequences coding for the protein. Efficient translation requires the prior synthesis within infected cells of a smaller RNA carrying only a portion of the information encoded in the whole genome. 相似文献
95.
Summary Reducible compounds, probably similar to lysine-derived cross-links found in collagen and elastin, have been detected in an invertebrate scleroprotein, the egg case ofBuccinum undatum (L.)During this studyN. R. Price was in receipt of an S.R.C. research assistantship. 相似文献
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Inhibition of rhinovirus by isatin thiosemicarbazone analogues 总被引:4,自引:0,他引:4
J M Gladych J H Hunt D Jack R F Haff J J Boyle R C Stewart R J Ferlauto 《Nature》1969,221(5177):286-287
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Parathyroid hormone-responsive adenylate cyclase in induced transplantable osteogenic rat sarcoma. 总被引:8,自引:0,他引:8
T J Martin P M Ingleton J C Underwood V P Michelangeli N H Hunt R A Melick 《Nature》1976,260(5550):436-438
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