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For several decades, most planetary researchers have regarded the impact crater populations on solid-surfaced planets and smaller bodies as predominantly reflecting the direct ('primary') impacts of asteroids and comets. Estimates of the relative and absolute ages of geological units on these objects have been based on this assumption. Here we present an analysis of the comparatively sparse crater population on Jupiter's icy moon Europa and suggest that this assumption is incorrect for small craters. We find that 'secondaries' (craters formed by material ejected from large primary impact craters) comprise about 95 per cent of the small craters (diameters less than 1 km) on Europa. We therefore conclude that large primary impacts into a solid surface (for example, ice or rock) produce far more secondaries than previously believed, implying that the small crater populations on the Moon, Mars and other large bodies must be dominated by secondaries. Moreover, our results indicate that there have been few small comets (less than 100 m diameter) passing through the jovian system in recent times, consistent with dynamical simulations. 相似文献
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Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean 总被引:30,自引:0,他引:30
Clapham JC Arch JR Chapman H Haynes A Lister C Moore GB Piercy V Carter SA Lehner I Smith SA Beeley LJ Godden RJ Herrity N Skehel M Changani KK Hockings PD Reid DG Squires SM Hatcher J Trail B Latcham J Rastan S Harper AJ Cadenas S Buckingham JA Brand MD Abuin A 《Nature》2000,406(6794):415-418
Uncoupling protein-3 (UCP-3) is a recently identified member of the mitochondrial transporter superfamily that is expressed predominantly in skeletal muscle. However, its close relative UCP-1 is expressed exclusively in brown adipose tissue, a tissue whose main function is fat combustion and thermogenesis. Studies on the expression of UCP-3 in animals and humans in different physiological situations support a role for UCP-3 in energy balance and lipid metabolism. However, direct evidence for these roles is lacking. Here we describe the creation of transgenic mice that overexpress human UCP-3 in skeletal muscle. These mice are hyperphagic but weigh less than their wild-type littermates. Magnetic resonance imaging shows a striking reduction in adipose tissue mass. The mice also exhibit lower fasting plasma glucose and insulin levels and an increased glucose clearance rate. This provides evidence that skeletal muscle UCP-3 has the potential to influence metabolic rate and glucose homeostasis in the whole animal. 相似文献
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Sliding-layer conformational change limited by the quaternary structure of plant RuBisCO 总被引:1,自引:0,他引:1
RuBisCO, D-ribulose-1,5-bisphosphate carboxylase-oxygenase (EC 4.1.1.39), converts carbon dioxide to sugar in the first step of photosynthesis. In plants and some bacteria, this enzyme has an L8S8 structure, where L is the large catalytic subunit and S is the small subunit of unknown function. The molecule resembles a keg 105 A along the 4-fold axis and 132 A in diameter at the widest point of the keg. Here we describe the quaternary structure of RuBisCO from N. tabacum, the first L8S8 type known from an X-ray crystallographic study at near-atomic resolution (3 A). The structure shows that all eight L subunits are elongated along the 4-fold axis so that the molecule cannot be simply described as layers of subunits, as it had been from studies by electron microscopy. The structure, with its elongated and interdigitated L subunits, is evidence against a large, sliding-layer conformational change in plant RuBisCO, as proposed recently in Nature for the same enzyme from Alcaligenes eutrophus. 相似文献
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D. D. Chapman J. M. Felts I. L. Chaikoff 《Cellular and molecular life sciences : CMLS》1955,11(7):283-286
Zusammenfassung Es wird für die Bestimmung des Leberglykogens eine Jod-Adsorptionsmethode mit der üblichen Hydrolyse zu Glukose verglichen. Für normale und unbehandelte diabetische Ratten zeigen die Glykogenwerte mit beiden Methoden gute Übereinstimmung. Dagegen ist die Farbintensität je Gewichtseinheit des Jod-Glykogen-Komplexes bei insulinbehandelten diabetischen Ratten ebenso wie bei fastenden glukosegefütterten Ratten wesentlich grösser als bei normalen Tieren. Daraus lässt sich schliessen, dass frisch gebildetes Glykogen eine erhöhte Jod-Adsorptionsfähigkeit besitzt. Qualitativ erfährt die Farbe des Jod-Glykogen-Komplexes unter den verschiedenen Bedingungen keine Veränderung. 相似文献
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