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STAT3 signalling is required for leptin regulation of energy balance but not reproduction 总被引:33,自引:0,他引:33
Bates SH Stearns WH Dundon TA Schubert M Tso AW Wang Y Banks AS Lavery HJ Haq AK Maratos-Flier E Neel BG Schwartz MW Myers MG 《Nature》2003,421(6925):856-859
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Unravelling angiosperm genome evolution by phylogenetic analysis of chromosomal duplication events 总被引:38,自引:0,他引:38
Conservation of gene order in vertebrates is evident after hundreds of millions of years of divergence, but comparisons of the Arabidopsis thaliana sequence to partial gene orders of other angiosperms (flowering plants) sharing common ancestry approximately 170-235 million years ago yield conflicting results. This difference may be largely due to the propensity of angiosperms to undergo chromosomal duplication ('polyploidization') and subsequent gene loss ('diploidization'); these evolutionary mechanisms have profound consequences for comparative biology. Here we integrate a phylogenetic approach (relating chromosomal duplications to the tree of life) with a genomic approach (mitigating information lost to diploidization) to show that a genome-wide duplication post-dates the divergence of Arabidopsis from most dicots. We also show that an inferred ancestral gene order for Arabidopsis reveals more synteny with other dicots (exemplified by cotton), and that additional, more ancient duplication events affect more distant taxonomic comparisons. By using partial sequence data for many diverse taxa to better relate the evolutionary history of completely sequenced genomes to the tree of life, we foster comparative approaches to the study of genome organization, consequences of polyploidy, and the molecular basis of quantitative traits. 相似文献
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Decreased stability of methane hydrates in marine sediments owing to phase-boundary roughness 总被引:5,自引:0,他引:5
Below water depths of about 300 metres, pressure and temperature conditions cause methane to form ice-like crystals of methane hydrate. Marine deposits of methane hydrate are estimated to be large, amassing about 10,000 gigatonnes of carbon, and are thought to be important to global change and seafloor stability, as well as representing a potentially exploitable energy resource. The extent of these deposits can usually be inferred from seismic imaging, in which the base of the methane hydrate stability zone is frequently identifiable as a smooth reflector that runs parallel to the sea floor. Here, using high-resolution seismic sections of seafloor sediments in the Cascadia margin off the coast of Vancouver Island, Canada, we observe lateral variations in the base of the hydrate stability zone, including gas-rich vertical intrusions into the hydrate stability zone. We suggest that these vertical intrusions are associated with upward flow of warmer fluids. Therefore, where seafloor fluid expulsion and methane hydrate deposits coincide, the base of the hydrate stability zone might exhibit significant roughness and increased surface area. Increased area implies that significantly more methane hydrate lies close to being unstable and hence closer to dissociation in the event of a lowering of pressure due to sea-level fall. 相似文献
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Veverka J Farquhar B Robinson M Thomas P Murchie S Harch A Antreasian PG Chesley SR Miller JK Owen WM Williams BG Yeomans D Dunham D Heyler G Holdridge M Nelson RL Whittenburg KE Ray JC Carcich B Cheng A Chapman C Bell JF Bell M Bussey B Clark B Domingue D Gaffey MJ Hawkins E Izenberg N Joseph J Kirk R Lucey P Malin M McFadden L Merline WJ Peterson C Prockter L Warren J Wellnitz D 《Nature》2001,413(6854):390-393
The NEAR-Shoemaker spacecraft was designed to provide a comprehensive characterization of the S-type asteroid 433 Eros (refs 1,2,3), an irregularly shaped body with approximate dimensions of 34 x 13 x 13 km. Following the completion of its year-long investigation, the mission was terminated with a controlled descent to its surface, in order to provide extremely high resolution images. Here we report the results of the descent on 12 February 2001, during which 70 images were obtained. The landing area is marked by a paucity of small craters and an abundance of 'ejecta blocks'. The properties and distribution of ejecta blocks are discussed in a companion paper. The last sequence of images reveals a transition from the blocky surface to a smooth area, which we interpret as a 'pond'. Properties of the 'ponds' are discussed in a second companion paper. The closest image, from an altitude of 129 m, shows the interior of a 100-m-diameter crater at 1-cm resolution. 相似文献
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A new H-2-linked class I gene whose expression depends on a maternally inherited factor 总被引:1,自引:0,他引:1
The maternally transmitted antigen (Mta) is expressed on the cells of most strains of mice. It is a medial histocompatibility antigen, that is, it is recognized by unrestricted cytotoxic T lymphocytes as are major H antigens, but unlike these it is a weak transplantation antigen and does not itself restrict the T-cell recognition of minor H antigens. All other medial H antigens are encoded by genes closely linked to the major histocompatibility complex, H-2 in the mouse. By contrast, Mta appeared to follow extrachromosomal, maternal inheritance. Several substrains of NZB, NZO and non-inbred European NMRI mice are Mta-negative. Females of these strains bear only Mta- offspring, while females of the inbred Mta+ strains bear only Mta+ offspring. Repeated backcrossing from Mta+ females to NZB or NMRI males has shown that, given the right cytoplasmic genes, the chromosomal genes of these Mta- strains permit expression of Mta2. As the Mta type of a mouse cannot be influenced by embryo transfer or foster nursing, we concluded that it was determined by a cytoplasmic factor (Mtf), transmitted through the egg. We now show that a gene, Hmt, closely linked to the H-2 complex, is also required for expression of Mta. 相似文献
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