排序方式: 共有37条查询结果,搜索用时 15 毫秒
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Zusammenfassung Der Einfluss von Cholecystokinin-Pankrcozymin auf die Sekretion von Pepsin wurde in Hunden mit Heidenhain-Tasche untersucht. Während submaximaler Pepsinstimulation mit Mecholyl verminderte i.v. Injektion von Cholecystokinin-Pankreozymin die Pepsin-Sekretion im Magen signifikant. Es wird vermutet, dass CCK-PZ Enterogastrone sein könnte. 相似文献
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Carrageenin-induced oedema in rats was potentiated by oral administration of (4R)-3-[(2S)-3-mercapto-2-methylpropanoyl]-4-thiazolidinecarboxylic acid (SA291) and related sulfhydryl compounds, and the effect was closely correlated with their potencies as inhibitors of angiotensin-converting enzyme in vivo. 相似文献
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Miyamoto Y Shi D Nakajima M Ozaki K Sudo A Kotani A Uchida A Tanaka T Fukui N Tsunoda T Takahashi A Nakamura Y Jiang Q Ikegawa S 《Nature genetics》2008,40(8):994-998
Susceptibility to osteoarthritis, the most common human arthritis, is known to be influenced by genetic factors. Through a genome-wide association study using approximately 100,000 SNPs, we have identified a previously unknown gene on chromosome 3p24.3, DVWA, which is associated with susceptibility to knee osteoarthritis. Expressed specifically in cartilage, DVWA encodes a 276-amino-acid protein with two regions corresponding to the von Willebrand factor type A domain (VWA domain). Several DVWA SNPs are significantly associated with knee osteoarthritis in two independent Japanese case-control cohorts. This association was replicated in a Japanese population cohort and a Han Chinese case-control cohort (combined P = 7.3 x 10(-11)). DVWA protein binds to beta-tubulin, and the binding is influenced by two highly associated missense SNPs (rs11718863 and rs7639618) located in the VWA domain. The Tyr169-Cys260 isoform of DVWA, which is overrepresented in knee osteoarthritis, showed weaker interaction. Our findings reveal a new paradigm for study of osteoarthritis etiology and pathogenesis. 相似文献
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