全文获取类型
收费全文 | 62篇 |
免费 | 0篇 |
专业分类
系统科学 | 1篇 |
理论与方法论 | 2篇 |
现状及发展 | 26篇 |
研究方法 | 3篇 |
综合类 | 30篇 |
出版年
2018年 | 1篇 |
2017年 | 1篇 |
2016年 | 1篇 |
2014年 | 1篇 |
2012年 | 1篇 |
2011年 | 3篇 |
2010年 | 1篇 |
2009年 | 3篇 |
2008年 | 1篇 |
2007年 | 6篇 |
2006年 | 4篇 |
2005年 | 5篇 |
2004年 | 4篇 |
2003年 | 2篇 |
2002年 | 2篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1986年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1979年 | 3篇 |
1975年 | 1篇 |
1972年 | 1篇 |
1970年 | 4篇 |
1966年 | 1篇 |
1957年 | 1篇 |
1956年 | 1篇 |
1947年 | 1篇 |
1946年 | 1篇 |
排序方式: 共有62条查询结果,搜索用时 46 毫秒
51.
Summary Internal Ba2+ blocks both the Ca-dependent component, as well as the voltage-dependent component of the K+ current in molluscan pacemaker neurons. 相似文献
52.
6B1细胞的低频弱电磁场效应研究 总被引:3,自引:0,他引:3
以小鼠6B1骨髓瘤细胞为效应靶细胞,采用细胞化学(MTT),免疫酶标(ELISA)等方法,研究了低频弱电磁场对6B1细胞代谢的影响。结果表明:(1)1mV/cm的低频电场(10~100Hz)对6B1细胞的增殖无明显作用,而1mV/cm,50Hz电场对6B1细胞乙肝表面抗体的分泌有显著促进,提示在此条件下电场对6B1细胞膜的外侧存在某种特异性作用;(2)0.8T、30Hz的弱磁场对6B1细胞的增殖有 相似文献
53.
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6 总被引:1,自引:0,他引:1
Häcker H Redecke V Blagoev B Kratchmarova I Hsu LC Wang GG Kamps MP Raz E Wagner H Häcker G Mann M Karin M 《Nature》2006,439(7073):204-207
Toll-like receptors (TLRs) are activated by pathogen-associated molecular patterns to induce innate immune responses and production of pro-inflammatory cytokines, interferons and anti-inflammatory cytokines. TLRs activate downstream effectors through adaptors that contain Toll/interleukin-1 receptor (TIR) domains, but the mechanisms accounting for diversification of TLR effector functions are unclear. To dissect biochemically TLR signalling, we established a system for isolating signalling complexes assembled by dimerized adaptors. Using MyD88 as a prototypical adaptor, we identified TNF receptor-associated factor 3 (TRAF3) as a new component of TIR signalling complexes that is recruited along with TRAF6. Using myeloid cells from TRAF3- and TRAF6-deficient mice, we show that TRAF3 is essential for the induction of type I interferons (IFN) and the anti-inflammatory cytokine interleukin-10 (IL-10), but is dispensable for expression of pro-inflammatory cytokines. In fact, TRAF3-deficient cells overproduce pro-inflammatory cytokines owing to defective IL-10 production. Despite their structural similarity, the functions of TRAF3 and TRAF6 are largely distinct. TRAF3 is also recruited to the adaptor TRIF (Toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta) and is required for marshalling the protein kinase TBK1 (also called NAK) into TIR signalling complexes, thereby explaining its unique role in activation of the IFN response. 相似文献
54.
Marsicano G Wotjak CT Azad SC Bisogno T Rammes G Cascio MG Hermann H Tang J Hofmann C Zieglgänsberger W Di Marzo V Lutz B 《Nature》2002,418(6897):530-534
Acquisition and storage of aversive memories is one of the basic principles of central nervous systems throughout the animal kingdom. In the absence of reinforcement, the resulting behavioural response will gradually diminish to be finally extinct. Despite the importance of extinction, its cellular mechanisms are largely unknown. The cannabinoid receptor 1 (CB1) and endocannabinoids are present in memory-related brain areas and modulate memory. Here we show that the endogenous cannabinoid system has a central function in extinction of aversive memories. CB1-deficient mice showed strongly impaired short-term and long-term extinction in auditory fear-conditioning tests, with unaffected memory acquisition and consolidation. Treatment of wild-type mice with the CB1 antagonist SR141716A mimicked the phenotype of CB1-deficient mice, revealing that CB1 is required at the moment of memory extinction. Consistently, tone presentation during extinction trials resulted in elevated levels of endocannabinoids in the basolateral amygdala complex, a region known to control extinction of aversive memories. In the basolateral amygdala, endocannabinoids and CB1 were crucially involved in long-term depression of GABA (gamma-aminobutyric acid)-mediated inhibitory currents. We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala. 相似文献
55.
M. -H. Antoine B. Pirotte M. Hermann P. de Tullio J. Delarge A. Herchuelz P. Lebrun 《Cellular and molecular life sciences : CMLS》1994,50(9):830-832
The present study aimed at comparing the effects of low concentrations of BPDZ 44, a new pyridothiadiazine derivative, and diazoxide on86Rb outflow,45Ca outflow,45Ca uptake and insulin release from rat pancreatic islets. Both drugs caused similar modifications, but the effects of BPDZ 44 on the cationic and secretory events were much more marked than those of diazoxide. It is suggested that BPDZ 44 could be valuable tool for further studies of the KATP channels. 相似文献
56.
57.
Aharonian FA Akhperjanian AG Aye KM Bazer-Bachi AR Beilicke M Benbow W Berge D Berghaus P Bernlöhr K Bolz O Boisson C Borgmeier C Breitling F Brown AM Gordo JB Chadwick PM Chitnis VR Chounet LM Cornils R Costamante L Degrange B Djannati-Ataï A Drury LO Ergin T Espigat P Feinstein F Fleury P Fontaine G Funk S Gallant YA Giebels B Gillessen S Goret P Guy J Hadjichristidis C Hauser M Heinzelmann G Henri G Hermann G Hinton JA Hofmann W Holleran M Horns D De Jager OC Jung I Khélifi B Komin N 《Nature》2004,432(7013):75-77
A significant fraction of the energy density of the interstellar medium is in the form of high-energy charged particles (cosmic rays). The origin of these particles remains uncertain. Although it is generally accepted that the only sources capable of supplying the energy required to accelerate the bulk of Galactic cosmic rays are supernova explosions, and even though the mechanism of particle acceleration in expanding supernova remnant (SNR) shocks is thought to be well understood theoretically, unequivocal evidence for the production of high-energy particles in supernova shells has proven remarkably hard to find. Here we report on observations of the SNR RX J1713.7 - 3946 (G347.3 - 0.5), which was discovered by ROSAT in the X-ray spectrum and later claimed as a source of high-energy gamma-rays of TeV energies (1 TeV = 10(12) eV). We present a TeV gamma-ray image of the SNR: the spatially resolved remnant has a shell morphology similar to that seen in X-rays, which demonstrates that very-high-energy particles are accelerated there. The energy spectrum indicates efficient acceleration of charged particles to energies beyond 100 TeV, consistent with current ideas of particle acceleration in young SNR shocks. 相似文献
58.
59.
60.
Résumé Présence de chitine constatée pour la première fois dans les septa branchiaux deBranchisotoma floridae. 相似文献