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Helmut Sigel 《Cellular and molecular life sciences : CMLS》1981,37(8):789-798
Summary The coenzymed-biotin offers in its anionic form to metal ions 3 possible binding sites: the carboxylate group of the valerate side chain, the ureido residue of the 2-imidazolidone ring, and the thioether sulfur of the tetrahydrothiophene ring; the coordinating properties of these groups are summarized and compared. Hydrogen bond formation of the ureido group has also been observed, and hydrogen bonding may possibly be important in biotin-bicarbonate recognition. The aliphatic part of the valeric acid side chain can undergo hydrophobic interactions. Such interactions and/or the stereoselective sulfur-metal ion coordination could be the means for a correct fixation of the biotinyl moiety at the surface of a protein, thus creating the active enzyme-substrate complex. 相似文献
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The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia 总被引:19,自引:0,他引:19
Levran O Attwooll C Henry RT Milton KL Neveling K Rio P Batish SD Kalb R Velleuer E Barral S Ott J Petrini J Schindler D Hanenberg H Auerbach AD 《Nature genetics》2005,37(9):931-933
Seven Fanconi anemia-associated proteins (FANCA, FANCB, FANCC, FANCE, FANCF, FANCG and FANCL) form a nuclear Fanconi anemia core complex that activates the monoubiquitination of FANCD2, targeting FANCD2 to BRCA1-containing nuclear foci. Cells from individuals with Fanconi anemia of complementation groups D1 and J (FA-D1 and FA-J) have normal FANCD2 ubiquitination. Using genetic mapping, mutation identification and western-blot data, we identify the defective protein in FA-J cells as BRIP1 (also called BACH1), a DNA helicase that is a binding partner of the breast cancer tumor suppressor BRCA1. 相似文献
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Min Yang Xinling Liu Jikun Chen Fanqi Meng Yuliang Zhang Helmut Brandl Thomas Lippert Nuofu Chen 《科学通报(英文版)》2014,59(17):1964-1967
A photoanode structure for dye-sensitized solar cells has been applied into the photocatalytic/electro- chemical cooperative degradation of methylene blue solu- tions. The low eutectic point of titanium dioxide (TiO2) with a fluorine-doped tin dioxide (FTO) conductive layer results in a high reactivity of TiO2 for the photocatalytic process as well as a good electron transfer for the elec- trochemical process. The porous TiO2 layer maintains a large surface area for the degradations. Through the com- binational process, the degradation velocity was improved by - 36 %, compared to a pure photocatalytic process. 相似文献