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271.
272.
Ca2+ influx evoked across the plasma membrane upon internal store depletion is essential for a myriad of cellular functions including
gene expression, cell proliferation, differentiation and even apoptosis. Darier’s disease (DD), an autosomal dominant inherited
disorder of the skin, arising due to mutations in the isoform 2 of the sarco (endo) plasmic reticulum Ca2+ ATPase (SERCA2), exemplifies an anomaly of Ca2+ signaling disturbances. Owing to loss of function mutations in SERCA2, keratinocytes in DD patients have a reduced pool of
endoplasmic reticulum (ER) Ca2+. Importantly, the status of ER Ca2+ is critical for the activation of a class of plasma membrane Ca2+ channels referred to as store operated Ca2+ channels (SOCs). The widely expressed transient receptor potential (TRP) family of channels is proposed to be SOCs. In this
review we discuss DD from the viewpoint of Ca2+ signaling and present a potential role for TRPC1 in the disease pathogenesis.
Received 30 August 2007; received after revision 17 October 2007; accepted 6 November 2007 相似文献
273.
H. P. Singh 《Cellular and molecular life sciences : CMLS》1976,32(11):1393-1394
Summary Seeds ofZornia diphylla possess a complex type of dormancy which is of great survival value for the species. Seeds show polymorphism. The optimum temperature for germination explains the cause of its distribution in the tropics. The grazing and scraping promotes the vegetative growth.The author is grateful to Dr.R. Sahai and Dr.R. S. Tripathi, Gorakhpur University, for guidance and to Dr.Y. B. Singh, Principal, and Dr.G. C. Srivastava, Head Dept. Botany, for encouragement and facilities. Thanks are due to my colleagues late SriP. N. Gupta, SriJ. Abraham, SriF. Abbasi, and Dr.A. B. Sinha for their cooperation. 相似文献
274.
A. N. Singh Hema Pande D. S. Bhakuni 《Cellular and molecular life sciences : CMLS》1976,32(11):1368-1369
Summary Coccuvine C17H19NO2, m.p. 137–38°, a new alkaloid fromCocculus laurifolius DC has been assigned the structure and stereochemistry as (I) on the basis of spectroscopic studies and chemical correlation. 相似文献
275.
Summary In earlier reports, LSD was found to induce extensive chromosomal aberrations in barley. With the same dose it is now observed that LSD is potent in the induction of chlorophyll mutations. This may be the first evidence that the drug induces gene mutations in plants.Acknowledgent. We are grateful to Dr H.K. Jain, Indian Agricultural Research Institute, for his interest and guidance. 相似文献
276.
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278.
Summary After administration of [3H]LSD to male rats, radioactivity was present in all tissues of the reproductive system, notably associated with spermatozoa in the epididymis. In addition, in pregnant rats LSD and/or metabolites readily crossed the placental barrier. 相似文献
279.
Usha R. Mehra U. B. Singh D. N. Verma S. K. Ranjhan 《Cellular and molecular life sciences : CMLS》1977,33(11):1547-1548
Summary Total microbial protein synthesis rates in the rumen of buffaloes were estimated by isotope dilution technique, using131I-albumin treated with tannic acid as a marker. The animals were fed groundnut cake treated with formaldehyde to meet 50% of their digestible crude protein (DCP) requirement and 2.5% urea molasses mixture was given to meet the remaining requirement of DCP. Wheat straw was fed as the basal roughage. The total average microbial protein synthesis was 58.14 g/day. 相似文献
280.