Nicotinamide administration alters the activities of hepatic microsomal mixed function oxidases

Summary Systemic action of nicotinamide significantly alters the activities of hepatic drug metabolizing enzymes. Male rats injected with nicotinamide have reduced levels of cytochrome P450, demethylases and aniline hydroxylase. The changes appear to be sex-dependent since in the case of female rats activities of p-nitroanisole-o-demethylase and aniline hydroxylase are enhanced whereas cytochrome P450 content remains unaltered.Authors gratefully acknowledge the encouragement given by Professor A.S. Paintal during the course of this investigation. One of us (J.K.B.) is grateful to the Council of Scientific and Industrial Research, New Delhi, for the award of a research fellowship.     

Effects of dehydration on rat's hypothalamic acid-phosphatase

Resumen Se constató un aumento significativo en el contenido de fosfatasa ácida del hipotálamo de ratas deshidratadas; estos resultados se discuten en relación a posibles mecanismos de secreción apócrina de las células neurosecretoras.     

Structure-activity relationship of the cardenolide,with special reference to the substituents and configurations at C-14 and C-15

Zusammenfassung Es wurden die kardiotonischen Wirkungen sechs neuer Derivate von 14-Deoxy-14H-digitoxigenin und 14-Deoxy-14-chloro-digitoxigenin auf das isolierte Froschherz untersucht, sowie die Beziehungen zwischen deren chemischen Strukturen und Wirkungen diskutiert.

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This study was supported by a research grant (No. 78 7012) from the Ministry of Education, Japan, and by a Grant-in-Aid from Tokyo Biochemical Research Foundation.     

A quantitative difference in the immune response to sheep red cells between rat strains

Résumé Des rats appartenant à plusieurs souches ont été immunisés par injection i.p. de 2×10⁸ globules rouges de mouton. La mesure du titre des haemolysines réalisée 6 jours plus tard montre des différences quantitatives selon les souches. Une réponse importante n'a pu être décelée que pour 3 d'entre elles (August, OFA et Wistar R).