Structure of an antibody combining site by magnetic resonance.

The structure of the combining site of the DNP binding IgA mouse myeloma protein MOPC 315 has been determined by a combination of high resolution nuclear magnetic resonance, electron spin resonance, model building and chemical modifications. This approach yields that general dimensions of the site, its polarity and asymmetry features, the assignment of the DNP-contact residues and their three-dimensional coordinates.     

Transposable genetic elements as agents of gene instability and chromosomal rearrangements.

Transposable genetic elements in prokaryotes and eukaryotes, when inserted at a given locus, can control expression of the locus and cause large scale rearrangements of adjacent DNA sequences. Striking similarities in genetic behaviour between the two groups of elements have led to the proposal of a molecular model of eukaryotic controlling elements, and to suggestions about the part such elements may play in evolution and differentiation.     

Three centuries of alcohol in the British diet.

Alcoholic drinks were consumed in larger quantities in the eighteenth and nineteenth centuries than in the twentieth century, although there has been a recent increase from the historical low of 1930-60. Beer, spirits and wines once provided at least 2 MJ (nearly 500 kcal) per person per day compared with 0.67 MJ (160 kcal) in 1975, towards an average energy requirement of the total population little different from that needed now. Beer has always contributed most to the alcohol, energy and nutrient content of the diet, although its importance relative to spirits and wine has declined.