Seawater subduction controls the heavy noble gas composition of the mantle

The relationship between solar volatiles and those now in the Earth's atmosphere and mantle reservoirs provides insight into the processes controlling the acquisition of volatiles during planetary accretion and their subsequent evolution. Whereas the light noble gases (helium and neon) in the Earth's mantle preserve a solar-like isotopic composition, heavy noble gases (argon, krypton and xenon) have an isotopic composition very similar to that of the modern atmosphere, with radiogenic and (in the case of xenon) solar contributions. Mantle noble gases in a magmatic CO2 natural gas field have been previously corrected for shallow atmosphere/groundwater and crustal additions. Here we analyse new data from this field and show that the elemental composition of non-radiogenic heavy noble gases in the mantle is remarkably similar to that of sea water. We challenge the popular concept of a noble gas 'subduction barrier'--the convecting mantle noble gas isotopic and elemental composition is explained by subduction of sediment and seawater-dominated pore fluids. This accounts for approximately 100% of the non-radiogenic argon and krypton and 80% of the xenon. Approximately 50% of the convecting mantle water concentration can then be explained by this mechanism. Enhanced recycling of subducted material to the mantle plume source region then accounts for the lower ratio of radiogenic to non-radiogenic heavy noble gas isotopes and higher water content of plume-derived basalts.     

Does democracy require value-neutral science? Analyzing the legitimacy of scientific information in the political sphere

Philosophers now commonly reject the value free ideal for science by arguing that non-epistemic values, including personal or social values, are permissible within the core of scientific research. However, little attention has been paid to the normative political consequences of this position. This paper explores these consequences and shows how political theory is fruitful for proceeding in a world without value-neutral science. I draw attention to an oft-overlooked argument employed by proponents of the value free ideal I dub the “political legitimacy argument.” This argument claims that the value-free ideal follows directly from the foundational principles of liberal democracy. If so, then the use of value-laden scientific information within democratic decision making would be illegitimate on purely political grounds. Despite highlighting this unaddressed and important argument, I show how it can be rejected. By appealing to deliberative democratic theory, I demonstrate scientific information can be value-laden and politically legitimate. The deliberative democratic account I develop is well suited for capturing the intuitions of many opponents of the value free ideal and points to a new set of questions for those interested in values in science.     

Genetic variation in selenoprotein S influences inflammatory response

Chronic inflammation has a pathological role in many common diseases and is influenced by both genetic and environmental factors. Here we assess the role of genetic variation in selenoprotein S (SEPS1, also called SELS or SELENOS), a gene involved in stress response in the endoplasmic reticulum and inflammation control. After resequencing SEPS1, we genotyped 13 SNPs in 522 individuals from 92 families. As inflammation biomarkers, we measured plasma levels of IL-6, IL-1beta and TNF-alpha. Bayesian quantitative trait nucleotide analysis identified associations between SEPS1 polymorphisms and all three proinflammatory cytokines. One promoter variant, -105G --> A, showed strong evidence for an association with each cytokine (multivariate P = 0.0000002). Functional analysis of this polymorphism showed that the A variant significantly impaired SEPS1 expression after exposure to endoplasmic reticulum stress agents (P = 0.00006). Furthermore, suppression of SEPS1 by short interfering RNA in macrophage cells increased the release of IL-6 and TNF-alpha. To investigate further the significance of the observed associations, we genotyped -105G --> A in 419 Mexican American individuals from 23 families for replication. This analysis confirmed a significant association with both TNF-alpha (P = 0.0049) and IL-1beta (P = 0.0101). These results provide a direct mechanistic link between SEPS1 and the production of inflammatory cytokines and suggest that SEPS1 has a role in mediating inflammation.     

Hispid pocket mouse ( Chaetodipus hispidus ) in east-central and northeastern Nebraska

The hispid pocket mouse ( Chaetodipus hispidus ) occurs throughout the Great Plains, mainly west of the Missouri River. In Nebraska, this species likely occurs throughout the state, but records of occurrence were lacking for east-central and northeastern counties. During a survey in 2008 for the plains pocket mouse ( Perognathus flavescens ) in eastern Nebraska, we documented C. hispidus in 10 new counties, including a modest range expansion into northeastern Nebraska. Many individuals were captured on moderately compact soils consisting of silt, but some also were captured on sandy and other friable soils. Most individuals were captured in areas containing some exposed ground, but this may reflect our trap placement for P. flavescens. Individuals from northeastern and east-central Nebraska best resembled C. h. spilotus from southeastern Nebraska, with black coloration suffused on the dorsum, head, and dorsal side of the tail; however, our individuals generally lacked the characteristic bright ochraceous coloration along lateral lines and on the dorsum. Limited evidence supports a recent expansion in distribution within the region.     

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

Although AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is a central member of possibly the most frequently activated proliferation and survival pathway in cancer, mutation of AKT1 has not been widely reported. Here we report the identification of a somatic mutation in human breast, colorectal and ovarian cancers that results in a glutamic acid to lysine substitution at amino acid 17 (E17K) in the lipid-binding pocket of AKT1. Lys 17 alters the electrostatic interactions of the pocket and forms new hydrogen bonds with a phosphoinositide ligand. This mutation activates AKT1 by means of pathological localization to the plasma membrane, stimulates downstream signalling, transforms cells and induces leukaemia in mice. This mechanism indicates a direct role of AKT1 in human cancer, and adds to the known genetic alterations that promote oncogenesis through the phosphatidylinositol-3-OH kinase/AKT pathway. Furthermore, the E17K substitution decreases the sensitivity to an allosteric kinase inhibitor, so this mutation may have important clinical utility for AKT drug development.     

A periodic shear-heating mechanism for intermediate-depth earthquakes in the mantle

Intermediate-depth earthquakes, at depths of 50-300 km in subduction zones, occur below the brittle-ductile transition, where high pressures render frictional failure unlikely. Their location approximately coincides with 600 to 800 degrees C isotherms in thermal models, suggesting a thermally activated mechanism for their origin. Some earthquakes may occur by frictional failure owing to high pore pressure that might result from metamorphic dehydration. Because some intermediate-depth earthquakes occur approximately 30 to 50 km below the palaeo-sea floor, however, the hydrous minerals required for the dehydration mechanism may not be present. Here we present an alternative mechanism to explain such earthquakes, involving the onset of highly localized viscous creep in pre-existing, fine-grained shear zones. Our numerical model uses olivine flow laws for a fine-grained, viscous shear zone in a coarse-grained, elastic half space, with initial temperatures from 600-800 degrees C and background strain rates of 10(-12) to 10(-15) s(-1). When shear heating becomes important, strain rate and temperature increase rapidly to over 1 s(-1) and 1,400 degrees C. The stress then drops dramatically, followed by low strain rates and cooling. Continued far-field deformation produces a quasi-periodic series of such instabilities.     

Acid sensing by the Drosophila olfactory system

The odour of acids has a distinct quality that is perceived as sharp, pungent and often irritating. How acidity is sensed and translated into an appropriate behavioural response is poorly understood. Here we describe a functionally segregated population of olfactory sensory neurons in the fruitfly, Drosophila melanogaster, that are highly selective for acidity. These olfactory sensory neurons express IR64a, a member of the recently identified ionotropic receptor (IR) family of putative olfactory receptors. In vivo calcium imaging showed that IR64a+ neurons projecting to the DC4 glomerulus in the antennal lobe are specifically activated by acids. Flies in which the function of IR64a+ neurons or the IR64a gene is disrupted had defects in acid-evoked physiological and behavioural responses, but their responses to non-acidic odorants remained unaffected. Furthermore, artificial stimulation of IR64a+ neurons elicited avoidance responses. Taken together, these results identify cellular and molecular substrates for acid detection in the Drosophila olfactory system and support a labelled-line mode of acidity coding at the periphery.