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排序方式: 共有228条查询结果,搜索用时 31 毫秒
91.
92.
Role of interferon in experimental mouse malaria 总被引:21,自引:0,他引:21
93.
Wen L Ley RE Volchkov PY Stranges PB Avanesyan L Stonebraker AC Hu C Wong FS Szot GL Bluestone JA Gordon JI Chervonsky AV 《Nature》2008,455(7216):1109-1113
Type 1 diabetes (T1D) is a debilitating autoimmune disease that results from T-cell-mediated destruction of insulin-producing beta-cells. Its incidence has increased during the past several decades in developed countries, suggesting that changes in the environment (including the human microbial environment) may influence disease pathogenesis. The incidence of spontaneous T1D in non-obese diabetic (NOD) mice can be affected by the microbial environment in the animal housing facility or by exposure to microbial stimuli, such as injection with mycobacteria or various microbial products. Here we show that specific pathogen-free NOD mice lacking MyD88 protein (an adaptor for multiple innate immune receptors that recognize microbial stimuli) do not develop T1D. The effect is dependent on commensal microbes because germ-free MyD88-negative NOD mice develop robust diabetes, whereas colonization of these germ-free MyD88-negative NOD mice with a defined microbial consortium (representing bacterial phyla normally present in human gut) attenuates T1D. We also find that MyD88 deficiency changes the composition of the distal gut microbiota, and that exposure to the microbiota of specific pathogen-free MyD88-negative NOD donors attenuates T1D in germ-free NOD recipients. Together, these findings indicate that interaction of the intestinal microbes with the innate immune system is a critical epigenetic factor modifying T1D predisposition. 相似文献
94.
95.
F. Halberg June Reinhardt F. C. Bartter Catherine Delea R. Gordon A. Reinberg J. Ghata M. Halhuber H. Hofmann R. Günther E. Knapp J. C. Pena M. Garcia Sainz 《Cellular and molecular life sciences : CMLS》1969,25(1):107-112
Zusammenfassung Circadiane Akrophasen — Gipfel der ungefähren 24-h-Periodik — von Blut- und Harnkortikosteroiden, Kalium im Harn, Körpertemperatur, Pulsrate und 2-min-Schätzung wurden mittels elektronischer Anpassung einer Kosinusfunktion vermöge der Methode der kleinsten Quadrate bestimmt. Solche Charakteristika circadianer Rhythmen empfehlen sich als Referenzstandarde dem Mediziner und Biologen durch ihre zufriedenstellende übereinstimmung in Daten von Untersuchungen auf verschiedenen Kontinenten mit zum Teil unterschiedlichen Methoden. 相似文献
96.
A lymphocyte-stimulating factor produced in vitro 总被引:15,自引:0,他引:15
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98.
Dennis P. Gordon Judy E. Sutherland Brenda A. Perez Andrea Waeschenbach Paul D. Taylor Emanuela Di Martino 《Journal of Natural History》2020,54(15-16):947-970
ABSTRACT The status of Conopeum Gray, 1848 in New Zealand is clarified, confirming the presence of three living species – one a naturalised alien, one new to science, and a third that is also known in the Pleistocene. Conopeum seurati (Canu, 1928), a Mediterranean-European species, is naturalised at three localities in New Zealand – Opua, Whangarei Harbour and Whanganui Inlet. Conopeum antipodum n. sp., previously confused with C. seurati, is an estuarine species distributed from Kaipara Harbour to Lyttelton Harbour and is also found in Te Whanga Lagoon at Chatham Island (all New Zealand localities). Conopeum oretiensis Uttley, 1951, first described from Foveaux Strait, is known as far north as Kaipara and Manukau Harbours and is known as a Pleistocene fossil from Napier, New Zealand. There is one other solely fossil New Zealand species – Plio-Pleistocene Electra ongleyi Brown, 1952 is transferred to Conopeum. Sequence data from the 18SrDNA locus confirm that Conopeum antipodum n. sp. is resolved within Conopeum and is distinct from C. seurati. http://www.zoobank.org/urn:lsid:zoobank.org:act:4FED6730-1C70-4420-B1DA-F1D9046221DF http://www.zoobank.org/urn:lsid:zoobank.org.pub:5C130A99-0869-44A2-885C-338005FBCE07 相似文献
99.
ImmunoDetection is a novel technique combining perfusion chromatography technology with antibodies to perform the steps of an immunoassay in a flow-through column format. Sensitive and precise measurements are performed in seconds to minutes using automated liquid chromatography instrumentation. 相似文献
100.
Sharon L. Weinberg Peter G. Bryant Glenn W. Milligan Richard Church A. D. Gordon Gildas Brossier Brigitte Escofier Kathleen M. Carley Frank Critchle 《Journal of Classification》1989,6(1):121-161
Affiliated to Astrophysics Div., Space Science Department, European Space Agency. 相似文献