Social evolution: kin preference in a social microbe

Kin recognition helps cooperation to evolve in many animals, but it is uncertain whether microorganisms can also use it to focus altruistic behaviour on relatives. Here we show that the social amoeba Dictyostelium purpureum prefers to form groups with its own kin in situations where some individuals die to assist others. By directing altruism towards kin, D. purpureum should generally avoid the costs of chimaerism experienced by the related D. discoideum.     

The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design

The worldwide spread of H5N1 avian influenza has raised concerns that this virus might acquire the ability to pass readily among humans and cause a pandemic. Two anti-influenza drugs currently being used to treat infected patients are oseltamivir (Tamiflu) and zanamivir (Relenza), both of which target the neuraminidase enzyme of the virus. Reports of the emergence of drug resistance make the development of new anti-influenza molecules a priority. Neuraminidases from influenza type A viruses form two genetically distinct groups: group-1 contains the N1 neuraminidase of the H5N1 avian virus and group-2 contains the N2 and N9 enzymes used for the structure-based design of current drugs. Here we show by X-ray crystallography that these two groups are structurally distinct. Group-1 neuraminidases contain a cavity adjacent to their active sites that closes on ligand binding. Our analysis suggests that it may be possible to exploit the size and location of the group-1 cavity to develop new anti-influenza drugs.     

浅析城市水资源管理及利用

针对城市水环境污染严重、城市水利设施不完善、水资源管理缺乏经济学观念的状况,提出一系列强化城市水资源管理及利用的措施。     

新世纪图书馆员社会角色转换研究综述

就近几年图书馆界关于新世纪馆员意识转换及社会角色转换等方面的研究进行了综述,指出新时期的馆员要实现自我社会角色的转换,首先是要明确转换的必要性,然后采取有效的策略逐步地、系统地推进转换,才能取得较好的效果。     

浅谈电子信息资源的合法利用

网络时代,电子信息资源已成为人们进行科学研究、商业活动和共享信息的重要手段,与此同时,网上侵权行为也时有发生。指出了电子信息资源的侵权形式,探讨了在版权法允许的范围内合法利用电子信息资源的有关问题。     

论信息市场环境下的图书馆营销观

分析了信息市场的发展对图书馆信息资源建设、信息技术的开发以及信息传播方式和获取手段所产生的影响,探讨了面对激烈的市场竞争图书馆引入营销观念的必要性,并对具体的营销策略做了详尽的阐述。     

高校图书馆知识管理浅谈

知识管理是知识经济时代的一种全新的管理思想。阐述了高校图书馆在对自身实施知识管理时应注意的环节、存在的问题以及所要避免陷入的几个误区,并对未来的知识管理进行了展望。     

图书馆的人力资源建设

分析了人才资源与图书馆生存和发展的关系,指出：应从发现人才、重用人才和培养人才3个方面建立人才培养机制;同时强调只有加强领导班子建设才能充分发挥人才的作用。     

多元函数的中值定理

将多元函数在有向光滑曲线上的增量与在某点处的方向导数联系起来得到一个多元函数的中值定理，并由此得到可用方向导数研究多元函数性质的一些结果