基于微机的边界扫描测试主控系统的设计

分析了边界扫描测试技术的工作机制对测试主控系统的功能需求，提出了一种基于微机PCI总线的低成本边界扫描测试主控系统的硬件设计方案，该系统以PC机为平台，以用CPLD器件实现的JTAG主控器生成满足IEEE1149．1协议的边界扫描测试信号，并用普通的SRAM实现存存器共享，仿真表明，该系统产生的测试信号完全满足IEEE1149．1协议的时序要求，可用于IC和PCB的边界扫描测试，以及改进边界扫描测试的研究和实验。     

Gated regulation of CRAC channel ion selectivity by STIM1

Two defining functional features of ion channels are ion selectivity and channel gating. Ion selectivity is generally considered an immutable property of the open channel structure, whereas gating involves transitions between open and closed channel states, typically without changes in ion selectivity. In store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels, the molecular mechanism of channel gating by the CRAC channel activator, stromal interaction molecule 1 (STIM1), remains unknown. CRAC channels are distinguished by a very high Ca(2+) selectivity and are instrumental in generating sustained intracellular calcium concentration elevations that are necessary for gene expression and effector function in many eukaryotic cells. Here we probe the central features of the STIM1 gating mechanism in the human CRAC channel protein, ORAI1, and identify V102, a residue located in the extracellular region of the pore, as a candidate for the channel gate. Mutations at V102 produce constitutively active CRAC channels that are open even in the absence of STIM1. Unexpectedly, although STIM1-free V102 mutant channels are not Ca(2+)-selective, their Ca(2+) selectivity is dose-dependently boosted by interactions with STIM1. Similar enhancement of Ca(2+) selectivity is also seen in wild-type ORAI1 channels by increasing the number of STIM1 activation domains that are directly tethered to ORAI1 channels, or by increasing the relative expression of full-length STIM1. Thus, exquisite Ca(2+) selectivity is not an intrinsic property of CRAC channels but rather a tuneable feature that is bestowed on otherwise non-selective ORAI1 channels by STIM1. Our results demonstrate that STIM1-mediated gating of CRAC channels occurs through an unusual mechanism in which permeation and gating are closely coupled.     

Wavelet fractal character of overlapping signal

A new method based on the combining of the wavelet theory with the fractal theory and named wavelet fractal peak position method (WFPPM) is introduced to extract the number of the components and the relevant peak positions from overlapping signals in chemistry .The overlapping signal is first transformed into continuous wavelet transform value of time domain in certain dilation range via continuous wavelet transform (CWT),and then changed into capacity dimensions (Dc),The number of the components and the relevant positions of overlapping peaks can be identified easily according to the change of Dc.An investigation concerning the influence of different dilation ranges on the peak positions extracted by WFPPM is also provided .Studies show that the WFPPM is an efficient tool for extracting the peak positions and identifying the number of peaks from unresoloved signals,even when this kind of overlapping is significantly serious,Relative errors of lless than 1.0% in peak positions are found when WFPPM is used in the processing of the cadmium (Ⅱ)-indium(Ⅲ) mixture system .The analytical results demonstrate that the desired peak positions can be extracted conveniently ,accurately and rapidly from an unresoled signal via WFPPM,Tremendous developing and applications based on currently reported WFPPM in extracting overlapping signals would be expected in the near future.     

一种基于地形跟踪的航迹优化算法

以地形跟踪／地形回避为基础,提出了用轨迹的侧向仰角代替航迹的高度作为航迹规划的隐蔽性代价的概念．该方法结合航迹的航程代价和飞行器的各种机动能力约束,可以达到对已有航迹的优化作用,同时也可直接进行简单的控制点航迹规划．仿真研究结果表明,该算法满足飞行器飞行的各种条件,是一种可行方法,该方法速度快、规划出的航迹可以有效提升飞行器在飞行过程中的生存能力,可以在用于任务规划的同时,达到对航迹进行优化的目的．     

RNAi-mediated gene silencing in non-human primates

The opportunity to harness the RNA interference (RNAi) pathway to silence disease-causing genes holds great promise for the development of therapeutics directed against targets that are otherwise not addressable with current medicines. Although there are numerous examples of in vivo silencing of target genes after local delivery of small interfering RNAs (siRNAs), there remain only a few reports of RNAi-mediated silencing in response to systemic delivery of siRNA, and there are no reports of systemic efficacy in non-rodent species. Here we show that siRNAs, when delivered systemically in a liposomal formulation, can silence the disease target apolipoprotein B (ApoB) in non-human primates. APOB-specific siRNAs were encapsulated in stable nucleic acid lipid particles (SNALP) and administered by intravenous injection to cynomolgus monkeys at doses of 1 or 2.5 mg kg(-1). A single siRNA injection resulted in dose-dependent silencing of APOB messenger RNA expression in the liver 48 h after administration, with maximal silencing of >90%. This silencing effect occurred as a result of APOB mRNA cleavage at precisely the site predicted for the RNAi mechanism. Significant reductions in ApoB protein, serum cholesterol and low-density lipoprotein levels were observed as early as 24 h after treatment and lasted for 11 days at the highest siRNA dose, thus demonstrating an immediate, potent and lasting biological effect of siRNA treatment. Our findings show clinically relevant RNAi-mediated gene silencing in non-human primates, supporting RNAi therapeutics as a potential new class of drugs.     

Kinetic evaluation of the size-dependent decomposition performance of solvent-free microcellular polylactic acid foams

A thermal gravimetric method is described for evaluating the kinetics of cell size-dependent decomposition and lifetime estima- tion for microcellular tissue engineering scaffolds made of biodegradable polylactic acid(PLA)foams.PLA foam cell sizes from 550 to 20?m were fabricated experimentally using a solvent-free solid-state foaming technique under saturation pressures from 1 to 5 MPa.The thermal properties of the PLA foams with respect to the cell sizes were measured using thermal gravimetric analy- sis in a nitrogen atmosphere and the activation energy and pre-exponential factor were derived to evaluate the decomposition ki- netics and estimate lifetime.It was found that small cell sizes can be achieved under high saturation pressures and that the thermal stability of PLA decreases after the fabrication process.The cell size-dependent thermal stability and degradation rate indicate that a PLA foam of larger cell sizes has a shorter degradation time,a few tenths that of the PLA raw material,at a temperature of 37°C. The results suggest that it is feasible to optimize fabrication parameters to obtain appropriate cell sizes and lifetimes that satisfy the application requirements for various organs.This study provides the basis for precise scaffold design and quantitative analysis of PLA foams in tissue engineering applications.     

Observation of robust edge superconductivity in Fe(Se,Te) under strong magnetic perturbation

The iron-chalcogenide high temperature superconductor Fe(Se,Te) (FST) has been reported to exhibit complex magnetic ordering and nontrivial band topology which ...     

Dynamic Analysis of Cable Roofs Under Transient Wind:A Comparison Between Time Domain and Frequency Domain Approaches

At present, high-speed computing capabilities and advanced nonlinear dynamic finite element procedures enable detailed dynamic analysis of cable structures. Although deterministic approaches require considerable analysis time and effort in relation to modeling, running, and data processing, they seem to be the only alternative to obtain high accuracy. Detailed dynamic analysis of cable roof networks is sophisticated and requires advanced modeling expertise. This paper presents a comparison between detailed nonlinear dynamic analysis and a simplified frequency domain approach to estimate the maximum probable response of weakly nonlinear cable roofs. The approach can be considered as alternative to detailed time-domain analysis in the preliminary design phase, or can be used to validate results obtained from more elaborated numerical models. The proposed method is illustrated with two examples of cable net roofs that were also analysed in the time domain.     

由电流环实现的多机通信系统

为解决恶劣环境下的远距离通信问题,本文设计了由电流环实现的多机通信系统,实践表明,该系统运行可靠,传输距离远,抗干扰能力强。     

油藏数值模拟在剩余油预测中的不确定性分析

油藏数值模拟作为一种定量的剩余油饱和度预测方法 ,在油田开发后期剩余油分布研究中起着越来越重要的作用 ,但其预测精度也不可避免地受到多种因素的影响。对剩余油预测中油藏数值模拟精度的影响因素进行了分析 ,结果表明 ,地层对比的多解性、储层物性参数求取的不确定性以及储层非均质描述的局限性是影响数值模拟精度的主要地质因素。此外 ,相对渗透率曲线的选取、动态数据的获取及数值模拟软件本身都存在较大的不确定性 ,这些都会影响到油藏数值模拟的精度。因此 ,在剩余油研究过程中 ,不能过分依赖油藏数值模拟。应该综合运用地质、地震、测井、油藏工程、油藏数值模拟等多学科知识进行研究 ,以提高剩余油饱和度的预测精度。