玉米秸炭低温燃烧热效应及燃尽时间实验

秸秆炭低温燃烧可抑制灰中的钾、钠、氯等的逸出,减少结渣、沾污和气相颗粒物的排放.为明确低温下炭氧化过程主要特性,采用同步热分析仪对玉米秸炭进行了实验.根据热流及失重速率曲线,确定了玉米秸炭低温燃烧温度范围,分析了燃烧温度、空气流量、堆积尺寸对CO/CO2值的影响,计算了动力学参数、堆积燃烧速率(燃尽时间).结果表明:玉米秸炭低温燃烧可采用500～680℃;CO/CO2值随温度的升高先增加后减小,增大空气流量、减小堆积尺寸均会降低CO/CO2值;秸秆炭动力燃烧时,在500、550、600、650℃下转化90％时所需时间分别为6.8、2.2、0.8、0.3 min.堆积燃烧时,500～680℃内,200 mL/min空气流量下,3、5、8 mg炭燃尽时间分别为15、18、25 min.以上结论可为玉米秸炭低温燃烧设备的设计提供依据.     

Roles of glial cells in synapse development

Brain function relies on communication among neurons via highly specialized contacts, the synapses, and synaptic dysfunction lies at the heart of age-, disease-, and injury-induced defects of the nervous system. For these reasons, the formation—and repair—of synaptic connections is a major focus of neuroscience research. In this review, I summarize recent evidence that synapse development is not a cell-autonomous process and that its distinct phases depend on assistance from the so-called glial cells. The results supporting this view concern synapses in the central nervous system as well as neuromuscular junctions and originate from experimental models ranging from cell cultures to living flies, worms, and mice. Peeking at the future, I will highlight recent technical advances that are likely to revolutionize our views on synapse–glia interactions in the developing, adult and diseased brain.     

On the Foundations of Constructive Mathematics – Especially in Relation to the Theory of Continuous Functions

We discuss the foundations of constructive mathematics, including recursive mathematics and intuitionism, in relation to classical mathematics. There are connections with the foundations of physics, due to the way in which the different branches of mathematics reflect reality. Many different axioms and their interrelationship are discussed. We show that there is a fundamental problem in BISH (Bishop’s school of constructive mathematics) with regard to its current definition of ‘continuous function’. This problem is closely related to the definition in BISH of ‘locally compact’. Possible approaches to this problem are discussed. Topology seems to be a key to understanding many issues. We offer several new simplifying axioms, which can form bridges between the various branches of constructive mathematics and classical mathematics (‘reuniting the antipodes’). We give a simplification of basic intuitionistic theory, especially with regard to so-called ‘bar induction’. We then plead for a limited number of axiomatic systems, which differentiate between the various branches of mathematics. Finally, in the appendix we offer BISH an elegant topological definition of ‘locally compact’, which unlike the current definition is equivalent to the usual classical and/or intuitionistic definition in classical and intuitionistic mathematics, respectively.     

A cryo-electron microscopic study of ribosome-bound termination factor RF2

Protein synthesis takes place on the ribosome, where genetic information carried by messenger RNA is translated into a sequence of amino acids. This process is terminated when a stop codon moves into the ribosomal decoding centre (DC) and is recognized by a class-1 release factor (RF). RFs have a conserved GGQ amino-acid motif, which is crucial for peptide release and is believed to interact directly with the peptidyl-transferase centre (PTC) of the 50S ribosomal subunit. Another conserved motif of RFs (SPF in RF2) has been proposed to interact directly with stop codons in the DC of the 30S subunit. The distance between the DC and PTC is approximately 73 A. However, in the X-ray structure of RF2, SPF and GGQ are only 23 A apart, indicating that they cannot be at DC and PTC simultaneously. Here we show that RF2 is in an open conformation when bound to the ribosome, allowing GGQ to reach the PTC while still allowing SPF-stop-codon interaction. The results indicate new interpretations of accuracy in termination, and have implications for how the presence of a stop codon in the DC is signalled to PTC.     

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

Epac proteins are activated by binding of the second messenger cAMP and then act as guanine nucleotide exchange factors for Rap proteins. The Epac proteins are involved in the regulation of cell adhesion and insulin secretion. Here we have determined the structure of Epac2 in complex with a cAMP analogue (Sp-cAMPS) and RAP1B by X-ray crystallography and single particle electron microscopy. The structure represents the cAMP activated state of the Epac2 protein with the RAP1B protein trapped in the course of the exchange reaction. Comparison with the inactive conformation reveals that cAMP binding causes conformational changes that allow the cyclic nucleotide binding domain to swing from a position blocking the Rap binding site towards a docking site at the Ras exchange motif domain.     

Metallurgy: high nickel release from 1- and 2-euro coins

The amount of nickel is regulated in European products that come into direct and prolonged contact with human skin because this metal may cause contact allergy, particularly hand eczema. Here we show that 1- and 2-euro coins induce positive skin-test reactions in sensitized individuals and release 240-320-fold more nickel than is allowed under the European Union Nickel Directive. A factor contributing to this high release of nickel is corrosion due to the bimetallic structure of these coins, which generates a galvanic potential of 30-40 mV in human sweat.