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31.
A. M. Sadr Florence Cardenas M. Tavassoli 《Cellular and molecular life sciences : CMLS》1980,36(5):605-606
Summary Ectopic autotransplants of the marrow tissue, form within 4 weeks, stable nodules which respond to erythropoietic modulation in a manner similar to other parts of the marrow. The findings indicate that these autotransplants are an integral part of the total hemopoietic mass.This work was supported by NIH grants AM25510 and AM70551 DOE contract DE-AS03-79EV00899. 相似文献
32.
Interdecadal variation in the extent of South Pacific tropical waters during the Younger Dryas event
During the Younger Dryas event, about 12,000 years ago, the Northern Hemisphere cooled by between 2 and 10 degrees C (refs 1, 2) whereas East Antarctica experienced warming. But the spatial signature of the event in the southern mid-latitudes and tropics is less well known, as records are sparse and inconclusive. Here we present high-resolution analyses of skeletal Sr/Ca and 18O/16O ratios for a giant fossil Diploastrea heliopora coral that was preserved in growth position on the raised reef terraces of Espiritu Santo Island, Vanuatu, in the southwestern tropical Pacific Ocean. Our data indicate that sea surface temperatures in Vanuatu were on average 4.5 +/- 1.3 degrees C cooler during the Younger Dryas event than today, with a significant interdecadal modulation. The amplified annual cycle of sea surface temperatures, relative to today, indicates that cooling was caused by the compression of tropical waters towards the Equator. The positive correlation in our record between the oxygen isotope ratios of sea water and sea surface temperatures suggests that the South Pacific convergence zone, which brings 18O-depleted precipitation to the area today, was not active during the Younger Dryas period. 相似文献
33.
Dujon B Sherman D Fischer G Durrens P Casaregola S Lafontaine I De Montigny J Marck C Neuvéglise C Talla E Goffard N Frangeul L Aigle M Anthouard V Babour A Barbe V Barnay S Blanchin S Beckerich JM Beyne E Bleykasten C Boisramé A Boyer J Cattolico L Confanioleri F De Daruvar A Despons L Fabre E Fairhead C Ferry-Dumazet H Groppi A Hantraye F Hennequin C Jauniaux N Joyet P Kachouri R Kerrest A Koszul R Lemaire M Lesur I Ma L Muller H Nicaud JM Nikolski M Oztas S Ozier-Kalogeropoulos O Pellenz S 《Nature》2004,430(6995):35-44
Identifying the mechanisms of eukaryotic genome evolution by comparative genomics is often complicated by the multiplicity of events that have taken place throughout the history of individual lineages, leaving only distorted and superimposed traces in the genome of each living organism. The hemiascomycete yeasts, with their compact genomes, similar lifestyle and distinct sexual and physiological properties, provide a unique opportunity to explore such mechanisms. We present here the complete, assembled genome sequences of four yeast species, selected to represent a broad evolutionary range within a single eukaryotic phylum, that after analysis proved to be molecularly as diverse as the entire phylum of chordates. A total of approximately 24,200 novel genes were identified, the translation products of which were classified together with Saccharomyces cerevisiae proteins into about 4,700 families, forming the basis for interspecific comparisons. Analysis of chromosome maps and genome redundancies reveal that the different yeast lineages have evolved through a marked interplay between several distinct molecular mechanisms, including tandem gene repeat formation, segmental duplication, a massive genome duplication and extensive gene loss. 相似文献
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Oxygen-evolving photosynthetic organisms regulate carbon metabolism through a light-dependent redox signalling pathway. Electrons are shuttled from photosystem I by means of ferredoxin (Fdx) to ferredoxin-thioredoxin reductase (FTR), which catalyses the two-electron-reduction of chloroplast thioredoxins (Trxs). These modify target enzyme activities by reduction, regulating carbon flow. FTR is unique in its use of a [4Fe-4S] cluster and a proximal disulphide bridge in the conversion of a light signal into a thiol signal. We determined the structures of FTR in both its one- and its two-electron-reduced intermediate states and of four complexes in the pathway, including the ternary Fdx-FTR-Trx complex. Here we show that, in the first complex (Fdx-FTR) of the pathway, the Fdx [2Fe-2S] cluster is positioned suitably for electron transfer to the FTR [4Fe-4S] centre. After the transfer of one electron, an intermediate is formed in which one sulphur atom of the FTR active site is free to attack a disulphide bridge in Trx and the other sulphur atom forms a fifth ligand for an iron atom in the FTR [4Fe-4S] centre--a unique structure in biology. Fdx then delivers a second electron that cleaves the FTR-Trx heterodisulphide bond, which occurs in the Fdx-FTR-Trx complex. In this structure, the redox centres of the three proteins are aligned to maximize the efficiency of electron transfer from the Fdx [2Fe-2S] cluster to the active-site disulphide of Trxs. These results provide a structural framework for understanding the mechanism of disulphide reduction by an iron-sulphur enzyme and describe previously unknown interaction networks for both Fdx and Trx (refs 4-6). 相似文献