全文获取类型
收费全文 | 11103篇 |
免费 | 18篇 |
国内免费 | 35篇 |
专业分类
系统科学 | 41篇 |
丛书文集 | 205篇 |
教育与普及 | 39篇 |
理论与方法论 | 49篇 |
现状及发展 | 5168篇 |
研究方法 | 492篇 |
综合类 | 5031篇 |
自然研究 | 131篇 |
出版年
2013年 | 97篇 |
2012年 | 165篇 |
2011年 | 294篇 |
2010年 | 66篇 |
2008年 | 189篇 |
2007年 | 209篇 |
2006年 | 203篇 |
2005年 | 228篇 |
2004年 | 188篇 |
2003年 | 189篇 |
2002年 | 201篇 |
2001年 | 286篇 |
2000年 | 293篇 |
1999年 | 189篇 |
1992年 | 176篇 |
1991年 | 149篇 |
1990年 | 153篇 |
1989年 | 158篇 |
1988年 | 165篇 |
1987年 | 157篇 |
1986年 | 168篇 |
1985年 | 228篇 |
1984年 | 140篇 |
1983年 | 140篇 |
1982年 | 98篇 |
1981年 | 116篇 |
1980年 | 150篇 |
1979年 | 377篇 |
1978年 | 282篇 |
1977年 | 304篇 |
1976年 | 219篇 |
1975年 | 220篇 |
1974年 | 340篇 |
1973年 | 278篇 |
1972年 | 299篇 |
1971年 | 308篇 |
1970年 | 418篇 |
1969年 | 364篇 |
1968年 | 365篇 |
1967年 | 334篇 |
1966年 | 292篇 |
1965年 | 213篇 |
1964年 | 69篇 |
1959年 | 117篇 |
1958年 | 211篇 |
1957年 | 169篇 |
1956年 | 160篇 |
1955年 | 132篇 |
1954年 | 132篇 |
1948年 | 104篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
911.
Plasmid-related anaerobic autotrophy of the novel archaebacterium Sulfolobus ambivalens 总被引:1,自引:0,他引:1
Three different species of the genus Sulfolobus, S. acidocaldarius, S. solfataricus (= Caldariella) and S. brierleyi, have been distinguished by the conditions required for optimal growth, by the component patterns of their DNA-dependent RNA polymerases and by DNA sequence data. Many isolates of these species are able to grow chemolithoautotrophically using CO2 as the sole carbon source and the oxidation of S(0) with O2 yielding sulphuric acid, as the energy source, though a few others grow only heterotrophically. We show here that a strain of a novel Sulfolobus species, S. ambivalens, is alternatively able to live by an anaerobic mode of chemolithoautotrophy, also using CO2 as the sole carbon source, but using reduction of S(0) with H2, yielding H2S as the energy source. This mode of growth is correlated with the amplification of a plasmid, pSL10. 相似文献
912.
Inositol phosphates and cell signalling 总被引:189,自引:0,他引:189
Inositol 1,4,5-trisphosphate is a second messenger which regulates intracellular calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by stimulating calcium entry. In these actions it may function with its phosphorylated metabolite, inositol 1,3,4,5-tetrakisphosphate. The subtlety of calcium regulation by inositol phosphates is emphasized by recent studies that have revealed oscillations in calcium concentration which are perhaps part of a frequency-encoded second-messenger system. 相似文献
913.
914.
T. Garland Jr A. F. Bennett C. B. Daniels 《Cellular and molecular life sciences : CMLS》1990,46(5):530-533
Summary Locomotor capacities and their physiological bases are thought to be of considerable selective importance in natural populations. Within this functional complex, organismal performance traits (e.g., speed, stamina) are expected to be of more direct selective importance than their suborganismal determinants (e.g., heart size). Quantitative genetics theory predicts that traits of greater selective importance should generally have lower heritabilities at equilibrium. Contrary to these expectations, we report that organismal performance traits had the highest heritabilities in a natural population of garter snakes. 相似文献
915.
F. Carlei J. M. Allen A. E. Bishop S. R. Bloom J. M. Polak 《Cellular and molecular life sciences : CMLS》1985,41(12):1554-1557
Summary Significant quantities of a newly discovered peptide, neuropeptide Y, were found in the rat pancreas, where they were localized to nerves in the exocrine parenchyma and around arterial and ductal structures. Although unaffected by surgical parasympathectomy, the periarterial and periductal nerves were abolished by chemical sympathectomy, suggesting that NPY is partially costored with sympathetic transmitters in nerve fibers. 相似文献
916.
Peripheral nervous system myelin is an extension of the Schwann cell's plasma membrane that tightly enwraps axons in many layers and permits nerve impulses to be rapidly conducted. It is not known how these multiple membrane layers are held together in this compact form. Here we present evidence supporting the hypothesis that the extracellular leaflets of myelin are held together by the most abundant protein of myelin of the peripheral nervous system, P0, by homophilic interaction of its extracellular domains. Transfected Chinese hamster ovary cells expressing P0 protein adhere to each other in suspension, to form large aggregates, whereas cells that are identical but which do not express P0 do not. We also show that this aggregation is mediated by homophilic binding between P0-expressing cells and that the apposing plasma membranes of these cells specifically form desmosomes, whereas control transfected cells do not. As the only difference between the two cell populations is the expression of P0, this protein is apparently responsible for the changes in morphology and adhesion in the cells that express it. The idea that P0 is a homophilic adhesion molecule is supported by its inclusion in the immunoglobulin supergene family, all members of which are involved in recognition and/or adhesion. 相似文献
917.
It has been suggested that arginine vasopressin (AVP) is involved in the retention of learned responses, in addition to its classical physiological functions of water retention and modulation of blood pressure. AVP administered subcutaneously (s.c.), intraventricularly or intracerebrally can prolong extinction of active avoidance behaviour and can enhance retention in inhibitory (passive) avoidance. These effects have been interpreted as a direct action of AVP on the central nervous system to facilitate memory consolidation. AVP also has facilitatory effects on cognitive function in humans, and marked deficits in AVP function have been associated with certain types of psychopathology. Alternative hypotheses for the behavioural actions of AVP have involved motivational constructs such as arousal, and our recent work has focused on the role of arousal resulting from the activation of peripheral visceral signals in the behavioural effects of peripherally administered AVP. The development of a specific antagonist for AVP, 1-deaminopenicillamine-2-O-methyl tyrosine arginine vasopressin (dPTyr(Me)AVP), which can reverse the behavioural effects of exogenously administered AVP, has provided a powerful tool for examining the role of AVP in the behavioural responses produced by physiological challenges known to release vasopressin. However, the relationship between the behavioural effects of exogenously administered AVP and the behavioural function of endogenously released AVP has not been evaluated. We report here that a potent peripheral osmotic stimulus, the intraperitoneal (i.p.) injection of hypertonic saline, at doses known to release AVP both centrally and peripherally, will produce behavioural effects similar to those of exogenously administered AVP. Furthermore, the prolongation of active avoidance induced by this osmotic stimulus is reversed by pretreatment with dPTyr(Me)AVP, suggesting that endogenously released AVP may also produce behavioural effects. 相似文献
918.
Immunoglobulin-related domains for cell surface recognition 总被引:4,自引:0,他引:4
A F Williams 《Nature》1985,314(6012):579-580
919.
920.