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Zusammenfassung Der Einbau von 1,2-3H-Corticosteron in die Mastzellen der lymphatischen Organe wurde bei Mäusen untersucht. Bei gleichzeitiger Anwendung von Autoradiographie und Elektronenmikroskopie konnte das Corticosteron in den Mastzellen nachgewiesen werden. 相似文献
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RASSF1A, the new guardian of mitosis 总被引:3,自引:0,他引:3
Máthé E 《Nature genetics》2004,36(2):117-118
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A receptor kinase gene regulating symbiotic nodule development 总被引:65,自引:0,他引:65
Leguminous plants are able to establish a nitrogen-fixing symbiosis with soil bacteria generally known as rhizobia. Metabolites exuded by the plant root activate the production of a rhizobial signal molecule, the Nod factor, which is essential for symbiotic nodule development. This lipo-chitooligosaccharide signal is active at femtomolar concentrations, and its structure is correlated with host specificity of symbiosis, suggesting the involvement of a cognate perception system in the plant host. Here we describe the cloning of a gene from Medicago sativa that is essential for Nod-factor perception in alfalfa, and by genetic analogy, in the related legumes Medicago truncatula and Pisum sativum. The identified 'nodulation receptor kinase', NORK, is predicted to function in the Nod-factor perception/transduction system (the NORK system) that initiates a signal cascade leading to nodulation. The family of 'NORK extracellular-sequence-like' (NSL) genes is broadly distributed in the plant kingdom, although their biological function has not been previously ascribed. We suggest that during the evolution of symbiosis an ancestral NSL system was co-opted for transduction of an external ligand, the rhizobial Nod factor, leading to development of the symbiotic root nodule. 相似文献
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Galectin-7 总被引:4,自引:0,他引:4
Galectins are a family of animal lectins with an affinity for β-galactosides. They are differentially expressed by various
tissues and appear to be functionally multivalent, exerting a wide range of biological activities both during development
and in adult tissue. Galectin-7, a member of this family, contributes to different events associated with the differentiation
and development of pluristratified epithelia. It is also associated with epithelial cell migration, which plays a crucial
role in the re-epithelialization process of corneal or epidermal wounds. In addition, recent evidence indicates that galectin-7,
designated as the product of the p53-induced gene 1 (PIG1), is a regulator of apoptosis through JNK activation and mitochondrial
cytochrome c release. Defects in apoptosis constitute one of the major hallmarks of human cancers, and galectin-7 can act
as either a positive or a negative regulatory factor in tumour development, depending on the histological type of the tumour.
Received 30 October 2005; received after revision 15 November 2005; accepted 25 November 2005 相似文献
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The direct effect of serotonin and antiserotonin agents on adrenal steroid biosynthesis was studied in isolated adrenal cells derived from patients with Cushing's syndrome. The results indicate that serotonin increases corticosterone production, while the serotonin antagonists cyproheptadine and methysergide depress adrenal steroid - particularly cortisol and aldosterone - biosynthesis. 相似文献
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T Kiss 《Experientia》1988,44(11-12):998-1000
Effect of CARP was investigated on snail neurones. It was found that CARP decreased the slowly inactivating Ca- and the Ca-activated K-currents. 相似文献
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Cytotoxic T lymphocytes (CTLs) destroy virally infected and tumorigenic cells by releasing the contents of specialized secretory lysosomes--termed 'lytic granules'--at the immunological synapse formed between the CTL and the target. On contact with the target cell, the microtubule organizing centre of the CTL polarizes towards the target and granules move along microtubules in a minus-end direction towards the polarized microtubule organizing centre. However, the final steps of secretion have remained unclear. Here we show that CTLs do not require actin or plus-end microtubule motors for secretion, but instead the centrosome moves to and contacts the plasma membrane at the central supramolecular activation cluster of the immunological synapse. Actin and IQGAP1 are cleared away from the synapse, and granules are delivered directly to the plasma membrane. These data show that CTLs use a previously unreported mechanism for delivering secretory granules to the immunological synapse, with granule secretion controlled by centrosome delivery to the plasma membrane. 相似文献