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61.
E. Aloj Totàro F. A. Pisanti L. Hernàdi 《Cellular and molecular life sciences : CMLS》1984,40(4):382-383
Summary The yellow-brown pigment present in the sensory cells ofAplysia limacina was studied using light and electron microscopy. The ultrastructure, the high carotenoid content and the presence in neurons for which a turnover process has been hypothesized, indicate that these pigments are cytosomes, organelles involved in the production of energy in anaerobiosis.This investigation was conducted at the Zoological Station of Naples. 相似文献
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R Cassingena H G Suàrez C Lavialle 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1977,285(16):1603-1606
Human and murine cells can be transformed in vitro following transfer of chromosomes (transfection) isolated from tumour (HeLa) or SV40-transformed (WI98VaD) human cells. An abortive transformation of Mouse cells is observed in soft-agar medium. An instability of the transformed phenotype is exhibited by the transfected human cells, following the isolation of colonies growing in soft-agar or low-serum medium. Nevertheless, two transformed cell lines (809 ch. VaD, Cl.5P and Cl.6P) could be established in culture. 相似文献
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Kleta R Romeo E Ristic Z Ohura T Stuart C Arcos-Burgos M Dave MH Wagner CA Camargo SR Inoue S Matsuura N Helip-Wooley A Bockenhauer D Warth R Bernardini I Visser G Eggermann T Lee P Chairoungdua A Jutabha P Babu E Nilwarangkoon S Anzai N Kanai Y Verrey F Gahl WA Koizumi A 《Nature genetics》2004,36(9):999-1002
Hartnup disorder, an autosomal recessive defect named after an English family described in 1956 (ref. 1), results from impaired transport of neutral amino acids across epithelial cells in renal proximal tubules and intestinal mucosa. Symptoms include transient manifestations of pellagra (rashes), cerebellar ataxia and psychosis. Using homozygosity mapping in the original family in whom Hartnup disorder was discovered, we confirmed that the critical region for one causative gene was located on chromosome 5p15 (ref. 3). This region is homologous to the area of mouse chromosome 13 that encodes the sodium-dependent amino acid transporter B(0)AT1 (ref. 4). We isolated the human homolog of B(0)AT1, called SLC6A19, and determined its size and molecular organization. We then identified mutations in SLC6A19 in members of the original family in whom Hartnup disorder was discovered and of three Japanese families. The protein product of SLC6A19, the Hartnup transporter, is expressed primarily in intestine and renal proximal tubule and functions as a neutral amino acid transporter. 相似文献
66.
Riassunto La conservazione al freddo degli eritrociti umani e di pollo per 6 giorni causa una fuoruscita di potassio dai globuli. Parte del potassio rientra nelle cellule durante incubazione a 37° C.La uabaina blocca questo fenomeno. L'insulina non ha effetto significativo nè sull'assunzione di potassio da parte del globulo rosso, nè sull'azione bloccante della uabaina.
Aided by a grant from the Chicago Heart Association.
Trainee, Diabetes Teaching Grant No. 2A-5102, National Institute of Arthritis and Metabolic Diseases, Public Health Service. 相似文献
Aided by a grant from the Chicago Heart Association.
Trainee, Diabetes Teaching Grant No. 2A-5102, National Institute of Arthritis and Metabolic Diseases, Public Health Service. 相似文献
67.
M Ermonval M A Persuy M Fellous G Lespinats H G Suàrez A Kay P Nardeux R Cassingena 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1979,288(20):1579-1582
Mouse embryo cells, transformed in vitro by the transfer of chromosomes from HeLa human tumour cells, express a surface antigen (s) also found on HeLa cells. This antigen(s), which has been detected both by indirect immunofluoresence and by a 125I-protein A binding assay, is not an antigen(s) shared by both Human and Mouse cells. 相似文献
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Haiman CA Chen GK Vachon CM Canzian F Dunning A Millikan RC Wang X Ademuyiwa F Ahmed S Ambrosone CB Baglietto L Balleine R Bandera EV Beckmann MW Berg CD Bernstein L Blomqvist C Blot WJ Brauch H Buring JE Carey LA Carpenter JE Chang-Claude J Chanock SJ Chasman DI Clarke CL Cox A Cross SS Deming SL Diasio RB Dimopoulos AM Driver WR Dünnebier T Durcan L Eccles D Edlund CK Ekici AB Fasching PA Feigelson HS Flesch-Janys D Fostira F Försti A Fountzilas G 《Nature genetics》2011,43(12):1210-1214
Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 × 10(-10)). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 × 10(-9)), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 × 10(-9)). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations. 相似文献