Effect of heavy physical training on the catecholamine content of the heart and adrenals of the guinea-pig

Zusammenfassung Ein langdauerndes Training bewirkt keine Herabsetzung der Catecholamine in Herz und Nebennieren des Meerschweinchens.

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This work has been supported by a grant from Svenska Nationalföreningen mot Hjärt- och Lungsjukdomar.     

Improvement of the Liu‐type Shiller estimator for distributed lag models

The problem of multicollinearity produces undesirable effects on ordinary least squares (OLS), Almon and Shiller estimators for distributed lag models. Therefore, we introduce a Liu‐type Shiller estimator to deal with multicollinearity for distributed lag models. Moreover, we theoretically compare the predictive performance of the Liu‐type Shiller estimator with OLS and the Shiller estimators by the prediction mean square error criterion under the target function. Furthermore, an extensive Monte Carlo simulation study is carried out to evaluate the predictive performance of the Liu‐type Shiller estimator.     

Forecasting Inflation Rates Using Daily Data: A Nonparametric MIDAS Approach

In this paper a nonparametric approach for estimating mixed‐frequency forecast equations is proposed. In contrast to the popular MIDAS approach that employs an (exponential) Almon or Beta lag distribution, we adopt a penalized least‐squares estimator that imposes some degree of smoothness to the lag distribution. This estimator is related to nonparametric estimation procedures based on cubic splines and resembles the popular Hodrick–Prescott filtering technique for estimating a smooth trend function. Monte Carlo experiments suggest that the nonparametric estimator may provide more reliable and flexible approximations to the actual lag distribution than the conventional parametric MIDAS approach based on exponential lag polynomials. Parametric and nonparametric methods are applied to assess the predictive power of various daily indicators for forecasting monthly inflation rates. It turns out that the commodity price index is a useful predictor for inflations rates 20–30 days ahead with a hump‐shaped lag distribution. Copyright © 2015 John Wiley & Sons, Ltd.     

Dorcadionini of Turkey (Coleoptera: Cerambycidae)

The Dorcadionini fauna of Turkey is reviewed, and a complete list with type information and provincial distributions is presented. Two hundred and seventy-eight species-group taxa are catalogued in total. This represents approximately 35% of the known Palaearctic Dorcadionini fauna. The Turkish Dorcadionini fauna is characterised by 227 endemic species-group taxa. So its endemism ratio is very high (approximately 82%). Distributions of the taxa in Turkey are given based on available literature records. Taxa in the list are arranged systematically under tribe, genus, subgenus (when recognised), species and subspecies (when recognised). The species group taxa whose occurrences in Turkey need conformation are not included in the list but are given separately. Additionally, two taxa are removed from the list: Dorcadion (Cribridorcadion) investitum Breuning in Braun, 1978a as nomen nudum and Dorcadion (Cribridorcadion) rosinae K. Daniel in Bodemeyer, 1900 as nomen nudum; and two taxa are given as status nov. and comb. nov.: Dorcadion (Cribridorcadion) atritarse Pic, 1931a and Dorcadion (Cribridorcadion) equestre bernhauerorum Peks, 2010. Moreover, a checklist of Dorcadionini of Turkey is presented in an appendix.     

Uncovering benefits and risks of integrated product service offerings — Using a case of technology encapsulation

The objective of this article is to uncover benefits and risks of Integrated Product Service Offering （IPSO） in a systematic manner. To do so, it adopts an explorative longitudinal in-depth case study （development of an IPSO based on a new technology） and adds insights to the existing literature. The article first proposes a theoretical and generic framework termed the PCP （Provider - Customer - Product） triangle with associated information flow and uncertainty. Second, various types of benefits and risks are presented based on the framework. Among others, the benefit of keeping IPR （Intellectual Property Rights） with the provider and the risk of regulation change are new findings from the case study. In addition, the case study reveals that IPSO is regarded as a positive contributor to innovation. Applying the framework and classification of benefits and risks as norms to other cases has yet to be done for verification. However, the framework contributes scientifically to a better understanding of the benefits and risks of IPSO. In addition, this framework is advantageous with its easiness to understand, which contributes practically to the dissemination of IPS0 insight to industry.     

Loss of virulence of canine distemper virus is associated with a structural change recognized by a monoclonal antibody

The monoclonal antibody (mAB) L1, which binds to the nucleocapsid protein of canine distemper virus (CDV), was shown to bind to avirulent CDV obtained after serial passages in Vero cells, but not to two different virulent demyelinating CDV-strains propagated in dog glial cell cultures. However, when both virulent CDV-strains were passaged through Vero cells they expressed, after a number of passages, an epitope recognized by mAB L1. The occurrence of the L1 epitope appeared to coincide with loss of virulence in animal inoculation experiments.     

Comparison of dihydrodiazepam enantiomers: Metabolism,serum binding and brain receptor binding

Summary Dihydrodiazepam is a diazepam prodrug, as shown by its in vitro metabolism by rat and mouse liver and brain microsomal fractions, and its displacing activity on brain diazepam binding. The mechanism of bioactivation is discussed. Stereoselectivity of metabolism and of binding to specific benzodiazepine binding sites in brain synpatosomes and serum albumin were studied.Acknowledgment. The authors are grateful to Dr. J. Wolford for the synthesis of³H-diazepam.     

Systemic Change in a Higher Education Institution: Inquiring into Organizational and Instructional Transformation

Systemic Practice and Action Research - Changes often occur in organizational systems due to the technology, new methods, new understandings and emerging needs. This study examined the reasons,...