DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and clomiphene

Summary Sulpiride administration to rats releases prolactin and increases DNA replication in the anterior pituitary gland. Clomiphene prevents the stimulation of DNA synthesis produced by sulpiride, but does not affect prolactin release from the gland. These findings suggest that the intracellular prolactin content of the anterior pituitary gland plays a role in the regulation of DNA synthesis through a mechanism mediated by oestrogens.This work was supported by PLAMIRH 99.178.1.78, by the Consejo Nacional de Investigaciones Científicas y Técnicas and by the Comisión Nacional de Energía Atómica (Argentina). We are grateful to Dr P. Scacchi for performing the radioimmunoassay and to Prof. C. J. Gómez for the opportunity to perform this work.     

Immunological profile of breast cancer patients in early or advanced disease

Summary Immune reactivity of patients with early or advanced breast cancer, compared with healthy controls, has been measured using in vivo and in vitro tests. The results of our study show that impairment of cellular responsiveness occurred in women with advanced disease.This work was supported in part by the CNR, Italy-USA Contract No. 7801062.65, and in part by the Region of Umbria, Italy. Acknowledgment. We wish to thank Mr Mario Andrielli for his expert technical assistance.     

Stimulus-response function at several levels of background luminance,in the cat visual areas 17 and 18

Summary Stimulus-response curves of simple cells of the visual cortex were obtained by using 500-msec stationary stimuli. Background influence on single unit responses was studied. The contrast sensitivity of simple cells increases as a function of background luminance. The resolution power of these cortical cells for detecting differences in stimulus contrast decreases at background levels above 0.09 cd/m².This investigation was supported by a grant from the Consiglio Nazionale delle Ricerche, Rome (Italy).     

Effect of lesions of the locus coeruleus complex on the circadian rhythm of plasma corticosterone in the mouse

Summary An apparently transient elevation of basal morning (08.00 h) plasma corticosterone levels in male mice was found 48 h after bilateral electrolytic lesions of the brainstem locus coeruleus complex but was not observed 6 weeks after lesioning.Supported by Alfred P. Sloan Foundation research fellowships awarded to W.G. Luttge and S.F. Zornetzer.     

Preparation of large volumes of linear gradient solutions for zonal ultracentrifugation

Résumé On décrit la construction d'un appareil à chambre close pour la préparation de gros volumes de solutions à gradients de densité linéaire. Ces solutions de sucre ou d'autres substances sont généralement utilisées pour l'ultracentrifugation zonale en gradient de densité.     

Reparation at increased oxygen supply

Zusammenfassung Ratten, die in 40% Sauerstoffatmosphäre gehalten wurden, wurden experimentelle Granulome mit Viskose-Zellulose Schwämmen s.c. induziert. Die Inkorporation von markiertem Cytidin stieg um 200% und die Synthese der Phospholipide um 80%. Die Einwirkung der Erhöhung des Sauerstoffgehaltes auf die Kollagensynthese sowohl in vivo als in vitro war additiv und betrug maximal 170%. Weder die Synthese der nichtkollagenen Proteine noch diejenige der Desoxyribonukleinsäuren war wesentlich verändert.

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Supported by institutional grants from the Sigrid Jusélius Foundation and U.S. Department of Agriculture, Foreign Research and Technical Programs Division.     

Stereospecificity of the prostaglandin 15-dehydrogenase from swine lung

Zusammenfassung Die stereochemischen Voraussetzungen der Prostaglandin-15-Dehydrogenase aus Schweinelunge werden im Hinblick auf die pharmakologische Aktivität anhand einer Reihe synthetischer Prostaglandin E₁-Präparate abgeklärt.

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This work was supported by grants from the U.S. National Institutes of Health to Harvard University and by O.N.R. and N.I.H. grants to the Worcester Foundation for Experimental Biology.     

Bronchodilator activity of prostaglandin E2 when administered by aerosol to three species

Zusammenfassung Es wird gezeigt, dass Prostaglandin in Aerosolform bei mehreren Arten als Bronchodilator wirkt. Die Wirksamkeit, natÜrliches Vorkommen und schnelle Metabolisierung der Prostaglandine sprechen fÜr eine therapeutische Verwendung als bronchodilatierende Aerosole.     

Suppression of antibody formation against sendai virus in the SV40 and adenovirus 16 infected hamsters

SV₄₀ 16. 9 . . .     

Relationship between the resting blood pressure and depressor responses evoked by compression of the eyeballs

Résumé Les corrélations entre le niveau de repos de la pression artérielle et le degré des effets dépressifs provoqués par la compression des yeux sont positives. Leur valeur dépend de l'intensité de la stimulation. Elle atteint son maximum à une intensité semblable à celle qui conditionne la plus forte amplification des réactions étudiées.