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991.
992.
993.
基于函数链神经网络的管道煤气流量计量系统 总被引:5,自引:1,他引:5
在管道煤气计量系统测量中引入管道煤气相对湿度修正,并采用湿度传感器转换相对湿度信号,利用函数链神经网络对管道煤气工况温度下所对应的水蒸汽饱和压力进行拟合,得到基于函数链神经网络的管道煤气流量计量模型和在线计量系统,从而大大简化管道煤气流量计量软件,在流量计设计范围内实现管道煤气流量实时在线计量.实际应用结果表明,该计量系统测量管道煤气流量误差小于0.7%. 相似文献
994.
Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors. 总被引:13,自引:0,他引:13
Calcium release from intracellular stores is a point of convergence for a variety of receptors involved in cell signaling. Consequently, the mechanism(s) by which cells differentiate between individual receptor signals is central to transmembrane communication. There are significant differences in timing and magnitude of Ca2+ release stimulated by the m2 and m3 muscarinic acetylcholine receptors. The m2 receptors couple to a pertussis toxin-sensitive G protein to activate phosphatidyl inositol hydrolysis weakly and to stimulate small, delayed and oscillatory chloride currents. In contrast, m3 receptors potently activate phosphatidyl inositol hydrolysis and stimulate large, rapid and transient chloride currents by a pertussis toxin-insensitive G protein pathway. Using confocal microscopy, we now show that the m2- and m3-coupled Ca2+ release pathways can also be spatially distinguished. At submaximal acetylcholine concentrations, both receptors stimulated pulses of Ca2+ release from discrete foci in random, periodic and frequently bursting patterns of activity. But maximal stimulation of m2 receptors increased the number of focal release sites, whereas m3 receptors invariably evoked a Ca2+ wave propagating rapidly just beneath the plasma membrane surface. Analysis of pertussis toxin sensitivity and hybrid m2-m3 muscarinic acetylcholine receptors confirmed that these Ca2+ release patterns represent distinct cell signalling pathways. 相似文献
995.
海底钴结壳采矿车微地形导向声纳探测的圆形阵设计 总被引:1,自引:0,他引:1
为解决海底钴结壳采矿车微地形导向探测性能差且不能检测同时到达的不同方向回波问题,提出构造声纳圆形平面阵以增强水平和垂直分辨率,设计新的均匀圆阵并在Fourier变换的框架下提出圆阵波束形成的快速算法,以提高探测系统的实时性。研究结果表明:圆形阵具有好的指向性,主波束比旁瓣高约5.5dB;在水底存在较强干扰的情况下,圆阵(14阵元)对于水底多结壳凸起目标仍具有较好的方向到达角分辨率,在不同的仰角(0·,-36·,-54·,72·)下对11处模拟钴结壳凸起物可实现准确定位。 相似文献
996.
Convergent evolution of cytokines. 总被引:1,自引:0,他引:1
997.
P. Milner V. Ralevic A. M. Hopwood E. Fehér J. Lincoln K. A. Kirkpatrick G. Burnstock 《Cellular and molecular life sciences : CMLS》1989,45(2):121-125
Substance P and choline acetyltransferase have been localised in a small proportion of endothelial cells of rat coronary arteries using electron microscopic immunocytochemistry. During a hypoxic period of 1 min, coronary vasodilatation was produced in the Langendorff heart preparation and increased levels of substance P and acetylcholine were released into the perfusate. The possibility that these substances are released from endothelial cells during hypoxia and contribute to the hyperaemic response is discussed. 相似文献
998.
Direct evidence that reverse cholesterol transport is mediated by high-density lipoprotein in rabbit 总被引:2,自引:0,他引:2
Mammalian cells obtain cholesterol for membrane synthesis mostly via the receptor-mediated endocytosis of low-density lipoprotein (LDL). Macrophages and vascular endothelium additionally have receptors that recognize certain modified forms of LDL (for example, acetyl-LDL). The process by which cholesterol returns from peripheral cells to hepatocytes (reverse cholesterol transport) has not been established; although tissue culture studies have favoured high-density lipoprotein (HDL) as the principal vehicle, the in vivo evidence for this is meagre. When cholesterol-loaded macrophages are incubated in medium containing plasma, cholesterol moves from the cells to HDL and is then esterified by lecithin/cholesterol acyltransferase. The accumulation of cholesteryl esters in the particles increases their size and decreases their density; enrichment with apoprotein E (apo E) also occurs, producing a decrease in electrophoretic mobility. We now report that similar changes occur in the circulating HDL of rabbits, when their peripheral tissues are loaded with cholesterol by intravenous (i.v.) injection of acetylated or native human LDL. This result suggests that HDL is involved in reverse cholesterol transport in vivo. 相似文献
999.
1000.
Cooperative tandem binding of met repressor of Escherichia coli 总被引:10,自引:0,他引:10
S E Phillips I Manfield I Parsons B E Davidson J B Rafferty W S Somers D Margarita G N Cohen I Saint-Girons P G Stockley 《Nature》1989,341(6244):711-715
We present biochemical and genetic data to support the hypothesis that the Escherichia coli met repressor, MetJ, binds to synthetic and natural operator sequences in tandem arrays such that repression depends not only on the affinity of the DNA-protein interaction, but also on protein-protein contacts along the tandem array. This represents a novel form of regulatory switch. Furthermore, there seems to be homology between the organization of the met and trp operators. 相似文献