全文获取类型
收费全文 | 30278篇 |
免费 | 125篇 |
国内免费 | 272篇 |
专业分类
系统科学 | 443篇 |
丛书文集 | 544篇 |
教育与普及 | 102篇 |
理论与方法论 | 131篇 |
现状及发展 | 11499篇 |
研究方法 | 1265篇 |
综合类 | 15928篇 |
自然研究 | 763篇 |
出版年
2013年 | 379篇 |
2012年 | 671篇 |
2011年 | 1443篇 |
2010年 | 447篇 |
2009年 | 394篇 |
2008年 | 773篇 |
2007年 | 848篇 |
2006年 | 853篇 |
2005年 | 804篇 |
2004年 | 641篇 |
2003年 | 528篇 |
2002年 | 514篇 |
2001年 | 838篇 |
2000年 | 870篇 |
1999年 | 613篇 |
1992年 | 483篇 |
1991年 | 401篇 |
1990年 | 412篇 |
1989年 | 396篇 |
1988年 | 382篇 |
1987年 | 397篇 |
1986年 | 365篇 |
1985年 | 476篇 |
1984年 | 410篇 |
1983年 | 280篇 |
1982年 | 313篇 |
1981年 | 284篇 |
1980年 | 346篇 |
1979年 | 782篇 |
1978年 | 590篇 |
1977年 | 617篇 |
1976年 | 515篇 |
1975年 | 585篇 |
1974年 | 763篇 |
1973年 | 684篇 |
1972年 | 675篇 |
1971年 | 775篇 |
1970年 | 964篇 |
1969年 | 820篇 |
1968年 | 816篇 |
1967年 | 816篇 |
1966年 | 711篇 |
1965年 | 547篇 |
1959年 | 303篇 |
1958年 | 493篇 |
1957年 | 358篇 |
1956年 | 307篇 |
1955年 | 282篇 |
1954年 | 301篇 |
1948年 | 205篇 |
排序方式: 共有10000条查询结果,搜索用时 859 毫秒
881.
龙门山中段茂汶─汶川韧性剪切带中可见到绿片岩相到角闪岩相的古生界。该地的巴罗型中压变质相相当于松潘—甘孜褶皱带中地壳的绿泥石带,构成了北东—南西向的茂汶—汶川变质带。雪隆包花岗岩体正位于该变质带的中心部位。三次韧性变形作用(D1~D3)造就了印支褶皱带,并在三叠纪末末形成了松潘—甘孜褶皱带。D1变形作用为北东—南西向的挤压作用和冲断作用,形成了大型的等斜褶皱,使古生界缩短和加厚。在持续的D2北京—南西向挤压作用下,松潘—甘孜褶皱带和稳定的扬子克拉通之间的差异应变由茂汶—汶川剪切带中非同轴左旋剪切作用所容纳。雪隆包花岗岩体是在D2变形作用的晚期侵入到剪切带的。产生蓝晶石的变质条件也是在D2或D2变形作用后出现的。D3变形作用为北西—南东向挤压,在局部地方形成糜棱岩状的道冲剪切带。这些特征与绿泥石退变质作用有关,揭示出在D3变形期间茂汶—汶川变质带有较大幅度的隆升。尽管雪隆包岩体在空间上与茂汶—汶川变质带有关,但作者认为其变质作用是岩层加厚引起的热作用重新达到平衡的产物,而不是由侵入作用引起的热接触变质作用。然而,与岩浆作用伴生的高温和活动性流体仍是产生D3局部变形和雪隆包岩体隆升的原因,这也是局部出现角闪告相 相似文献
882.
贵州植物园珍稀濒危蕨类植物 总被引:1,自引:0,他引:1
本文介绍引种自贵州各地及我国华中、华东和华东的贵州植物园内的珍稀濒危蕨类植物。除列表表示来源、现状等情况外,还对桫椤Alsphila spinulosa (Hook)Tryon,扇蕨Neocheiropteris plamatopedata (Bak.)Chsist,宽叶水韭Isoetes japonica A.Br.,中华水韭I.sinensis Palmer和截基盾蕨Neolepisorus 相似文献
883.
汽轮发电机端部似稳涡流场数学模型 总被引:4,自引:0,他引:4
导出了描述发是端部涡流场的边值问题,并讨论了此问题的确定性。导出了与此边值问题等价的条件变化问题,并给出了三维行波场下变分式的具体形式。对QFS-300-2型汽轮发电机的端部场作了实例计算,计算结果与测试结果是一致的,证实了本文所提出的数学模型的正确性。 相似文献
884.
本文使用SEM、EDS、EAS、XRD和电阻率测量技术,研究了工艺参数和加入(Co,Fe2O3)对PTC(V1-x,Crx)2O3陶瓷的显微结构和电性能的影响。实验结果表明,为了制造优良性能、高可靠的热敏电阻器,必须精确控制陶瓷组份和工艺。引人象C。这样的添加物是重要的,它主要以金属形式分布在基体中,同时发现添加物对试样致密度和电性能的影响也是有益的。 相似文献
885.
Alpha 1-adrenoceptor subtypes linked to different mechanisms for increasing intracellular Ca2+ in smooth muscle 总被引:2,自引:0,他引:2
Receptor-mediated increases in intracellular Ca2+ levels can be caused by release from intracellular organelles and/or influx from the extracellular fluid. Noradrenaline (NA) released from sympathetic nerves acts on alpha 1-adrenoceptors to increase cytosolic Ca2+ and promote smooth muscle contraction. In many cells activation of alpha 1-adrenoceptors causes formation of inositol 1,4,5-trisphosphate which promotes Ca2+ release from intracellular stores. The mechanism by which receptor activation opens cell surface Ca2+ channels is not known, although in some cases it may be secondary to formation of inositol phosphates or release of stored intracellular Ca2+ (ref. 3). However, alpha 1-adrenoceptors have recently been shown to have different pharmacological properties in different tissues, and it has been proposed that different alpha 1-adrenoceptor subtypes may control mobilization of intracellular Ca2+ and gating of extracellular Ca2+ influx. We here report evidence for two subtypes of alpha 1-adrenoceptors which cause contractile responses through different molecular mechanisms. One subtype stimulates inositol phosphate (InsP) formation and causes contractions which are independent of extracellular Ca2+, and the other does not stimulate inositol phosphate formation and causes contractions which require the influx of extracellular Ca2+ through dihydropyridine-sensitive channels. These results suggest that neurotransmitters and hormones may control Ca2+ release from intracellular stores and influx through voltage-gated membrane channels through distinct receptor subtypes. 相似文献
886.
Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins 总被引:9,自引:0,他引:9
Decay-accelerating factor (DAF), a glycoprotein that is anchored to the cell membrane by phosphatidylinositol, binds activated complement fragments C3b and C4b, thereby inhibiting amplification of the complement cascade on host cell membranes. Here, we report the molecular cloning of human DAF from HeLa cells. Analysis of DAF complementary DNAs revealed two classes of DAF messenger RNA, one apparently derived from the other by a splicing event that causes a coding frameshift near the C terminus. The apparent 'intron' sequence contains an Alu family member and encodes contiguous protein sequence. Two DAF proteins are therefore possible, having divergent C-terminal domains which differ in their hydrophobicity. Both mRNAs are found on polysomes, suggesting that both are translated. We propose that the major (90%) spliced DAF mRNA encodes membrane-bound DAF whereas the minor (10%) unspliced DAF mRNA may encode secreted DAF and we present expression data supporting this. The deduced DAF sequence contains four repeating units homologous to a consensus repeat found in a recently described family of complement proteins. 相似文献
887.
Suppression of in vitro haematopoiesis following human immunodeficiency virus infection 总被引:2,自引:0,他引:2
Viral infections are frequently associated with haematological disorders. Abnormalities including leukopenia, anaemia and thrombocytopenia are commonly observed in patients with the acquired immune deficiency syndrome (AIDS) or the AIDS-related complex (ARC). The underlying cause of these haematological abnormalities is poorly understood. We report here that bone marrow progenitors isolated from AIDS or ARC patients are responsive to recombinant human granulocyte-macrophage colony stimulating factor (rGM-CSF) and recombinant erythropoietin. Antibodies present in the serum of patients infected with the human immunodeficiency virus (HIV), however, could suppress the growth of these progenitors, but not the growth of progenitors from HIV seronegative controls. A component of this immune-mediated suppression appears to be antibodies directed towards the envelope glycoprotein (gp120) of HIV. 相似文献
888.
N E Simpson K K Kidd P J Goodfellow H McDermid S Myers J R Kidd C E Jackson A M Duncan L A Farrer K Brasch 《Nature》1987,328(6130):528-530
Multiple endocrine neoplasis type 2A (MEN2A) is one of several kinds of cancers that appear to be inherited in an autosomally dominant fashion. We have assigned the MEN2A locus to chromosome 10 by linkage with a new DNA marker (D10S5). The linkage led us to investigate other chromosome 10 markers and demonstrate linkage between the disease locus and the interstitial retinol-binding protein (IRBP) gene. The D10S5 locus was sublocalized to 10q21.1 by hybridization in situ and the IRBP gene to p11.2----q11.2 with a secondary site at q24----q25. The linkages were established using 292 members of five families, three different restriction fragment length polymorphisms (RFLPs) at D10S5 and two RFLPs recognized by the IRBP probe. The recombination frequencies from pairwise linkage analysis between the disease and two marker loci D10S5 and IRBP were 0.19 and 0.11, with maximum lod scores of 3.6 and 8.0 respectively. Ordering of the three loci by multipoint analysis placed the IRBP gene approximately midway between the disease and D10S5 loci. 相似文献
889.
The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene 总被引:1,自引:0,他引:1
R E Tanzi P H St George-Hyslop J L Haines R J Polinsky L Nee J F Foncin R L Neve A I McClatchey P M Conneally J F Gusella 《Nature》1987,329(6135):156-157
Amyloid beta-protein (AP) is a peptide of relative molecular mass (Mr) 42,000 found in the senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients with Alzheimer's disease and Down's syndrome (trisomy 21). Recent molecular genetic evidence has indicated that AP is encoded as part of a larger protein by a gene on chromosome 21 (refs 5-7). The defect in the inherited autosomal dominant form of Alzheimer's disease, familial Alzheimer's disease (FAD), has been mapped to the same approximate region of chromosome 21 by genetic linkage to anonymous DNA markers, raising the possibility that this gene product, which could be important in the pathogenesis of Alzheimer's disease, is also the site of the inherited defect in FAD (ref. 5). We have determined the pattern of segregation of the AP gene in FAD pedigrees using restriction fragment length polymorphisms. The detection of several recombination events with FAD suggests that the AP gene is not the site of the inherited defect underlying this disorder. 相似文献
890.
The expression of hybrid HIV:Ty virus-like particles in yeast 总被引:3,自引:0,他引:3