Percutaneous penetration of indomethacin

Summary ¹⁴C-Indomethacin (ID) was applied to the skin of guinea-pigs as an ointment. After several applications, the concentration of ID in the skin and muscle under the applied site reached a constant level. The concentration of ID in the muscle as well as the skin may be enough to exert an anti-inflammatory effect.     

Further studies on polyacrylamide gel electrophoresis of water-soluble proteolipid-protein from bovine brain white matter

Zusammenfassung Wasserlösliche, proteolipide Proteine wurden von der weissen Hirnsubstanz durch Isolierungsmethoden vonTenenbaum undFolch ² gewonnen. Ohne Lyophilisation ergab die Disk-Elektrophorese bei pH 8.3 zwei Banden.

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The authors express their appreciation to Dr.K. Ueki, Dr.Y. Takahashi, Dr.Y. Takemoto and Dr.T. Kotoku.     

Okinonellins A and B,two novel furanosesterterpenes,which inhibit cell division of fertilized starfish eggs,from the marine spongeSpongionella sp

Cellular and Molecular Life Sciences - Two novel furanosesterterpenes, okinonellins A (1) and B (2), have been isolated from the spongeSpongionella sp. Both compounds inhibit cell division of...     

Processing of a minimal antigenic peptide alters its interaction with MHC molecules

Before their recognition by T lymphocytes, protein antigens generally require processing by antigen-presenting cells. In a poorly understood series of events, the protein antigen is internalized, transformed and re-expressed on the surface of the antigen-presenting cell in association with gene products of the major histocompatibility complex (MHC). Small peptides derived from the native protein can be recognized in the absence of antigen processing, suggesting that processing involves proteolytic degradation. These peptides are thought to mimic the naturally produced peptide fragment. We describe here a synthetic peptide antigen of this type which does not require processing but which is nevertheless further processed by splenic antigen-presenting cells. Interestingly, this processing event specifically alters the interaction of the peptide with the class II MHC (Ia) molecule, markedly affecting both its potency as an antigen in vitro and its immunogenicity in vivo (IR gene control).     

Inhibition by testosterone of immune reactivity and of lymphoid regeneration in irradiated and marrow reconstituted mice

Zusammenfassung Nachweis, dass die Behandlung letal bestrahlter und mit isologem Knochenmark regenerierter Mäuse mit Testosteron zu starker Herabsetzung der immunologischen Reaktivität und zu eindeutiger Reduktion des lymphatischen Gewebes führt.

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Acknowledgements: This investigation was supported by a grant from the Scientific Research from the Japanese Ministry of Education.     

Circadian rhythm in adrenal adenyl cyclase and corticosterone abolished by medial forebrain bundle transection in the rat

Zusammenfassung Nachweis, dass die Nebennierenrinde von Ratten nicht nur eine rhythmische Tagesschwankung in ihrem Gehalt an Corticosteron, sondern auch eine Schwankung im Gehalt an Adenyl-Cyclase aufweist. Diese Rhythmen können durch eine stereotaktisch ausgeführte Trennung des medianen Vorderhirnbündels, welches zum Hypothalamus führt, aufgehoben werden.

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This work was supported by research grants No. NS-05002 and No. HD-04581 from the National Institutes of Health, USPHS.