Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition

Summary Using flurbiprofen, a chiral anti-inflammatory and analgesic 2-arylpropionic acid derivative, the enantiomers of which are not converted to each other (less than 5%) in rats or man, we obtained evidence that prostaglandin synthesis inhibition is primarily mediating the anti-inflammatory activity but prostaglandin synthesis independent mechanisms contribute to the analgesic effects. Thus, the S-form inhibited prostaglandin synthesis, inflammation and nociception in rats. The R-form had much less effect on prostaglandin synthesis and did not affect inflammation. It did, however, block nociception in rats almost as potently as the S-form. S-flurbiprofen, in contrast to the R-form, was clearly ulcerogenic in the gastrointestinal mucosa. These results indicate additional molecular mechanisms of analgesia and suggest the use of R-arylpropionic acids as analgesics.     

基于模糊神经网络方法的新构造控水专家系统

在对大量野外地质资料统计和综合分析基础上，依据地质专家在新构造领域的理论知识和成功经验，运用模糊数学理论和神经网络理论相结合的方法，提出一种用线性单元并联实现非线性划分的神经元网络模型，并研制出相应具有较强推理能力和学习功能、广泛用于非定性系统数据处理的专家系统，该系统经实例验证具有较强的适用性。     

积木式教学黑白电视机的设计

为方便教学,将电视机按功能分成9个部分,每个部分的元件安装在一块独立的电路板上,并用金属匣子封装成为一个电路模块,各模块通过接插件组合起来,就是一台完整的电视机。可对单个模块进行实验与检修操作。     

FROM MANUFACTURING SCHEDULING TO SUPPLY CHAIN COORDINATION：THE CONTROL OF COMPLEXITY AND UNCERTAINTY

With time-based competition and rapid technology advancements, effective manufacturingscheduling and supply chain coordination are critical to quickly respond to changing marketconditions. These problems, however, are difficult in view of inherent complexity and variousuncertainties involved. Based on a series of results by the authors, decomposition and coordination byusing Lagrangian relaxation is identified in this paper as an effective way to control complexity anduncertainty.A manufacturing scheduling problem is first formulated within the job shop context withuncertain order arrivals, processing times, due dates, and part priorities as a separable optimizationproblem. A solution methodology that combines Lagrangian relaxation, stochastic dynamicprogramming, and heuristics is developed. Method improvements to effectively solve large problemsare also highlighted. To extend manufacturing scheduling within a factory to coordinate autonomicmembers across chains of suppliers, a decentralized supply chai     

具有随机偏差的最优多段卡尔曼估值器

提出了具有随机偏差的最优多段卡尔曼估值器。针对状态模型与观测模型同时具有偏差且偏差模型噪声与状态模型噪声相关的情况 ,给出了具有随机偏差的状态方程的增广状态 ,并通过U V变换对卡尔曼估值器的协方差矩阵解耦得到了最优多段卡尔曼估值器。结果表明 ,多段卡尔曼估值器不仅是最优的 ,而且降低了计算的复杂度     

试述泰山碧霞元君演进的三个阶段

按照历史与逻辑相统一的方法，可将泰山碧霞元君的演化进程划分为三个阶段。最初，由曹操的名篇《气出唱》创造出泰山云霞仙境中的天仙玉女这一审芙意象，曹植、李白等诗人又不断加以描写、渲染，从而使泰山玉女在中固古代社会享有很高的知名度。然后，宋真宗为这位神女易玉像、砻石龛。引导泰山玉女从诗人的作品中走出，走进了香火缭绕的宫祠。最后。明宪宗修宫祠、赐颠名，其影响所度，使得明清时期的碧霞元君在京城及全国各地建庙，香火大盛，碧霞元君一名也沿用至今。与此同时，道士们一方面凭着斋醮科仪、住持焚修和承办庙套、营造节庆的狂欢气氛，对泰山玉女进行了卓有成效的炒作；另一方面凭着一片赤诚，兢兢业业，惨淡经营。博得了几代朝廷及地方官员对各种奉祭碧霞元君活动的赞赏和支持，这就使泰山碧霞元君成为中国道教的一大主神。     

The Huntington's disease candidate region exhibits many different haplotypes.

Analysis of 78 Huntington's disease (HD) chromosomes with multi-allele markers revealed 26 different haplotypes, suggesting a variety of independent HD mutations. The most frequent haplotype, accounting for about one third of disease chromosomes, suggests that the disease gene is between D4S182 and D4S180. However, the paucity of an expected class of chromosomes that can be related to this major haplotype by assuming single crossovers may reflect the operation of other mechanisms in creating haplotype diversity. Some of these mechanisms sustain alternative scenarios that do not require a multiple mutational origin for HD and/or its positioning between D4S182 and D4S180.     

桥头跳车原因分析及质量控制

文章针对桥头跳车原因的形成 ,就解决方法从施工工艺及质量控制方面作了介绍。