排序方式: 共有15条查询结果,搜索用时 15 毫秒
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Barrett JH Iles MM Harland M Taylor JC Aitken JF Andresen PA Akslen LA Armstrong BK Avril MF Azizi E Bakker B Bergman W Bianchi-Scarrà G Bressac-de Paillerets B Calista D Cannon-Albright LA Corda E Cust AE Dębniak T Duffy D Dunning AM Easton DF Friedman E Galan P Ghiorzo P Giles GG Hansson J Hocevar M Höiom V Hopper JL Ingvar C Janssen B Jenkins MA Jönsson G Kefford RF Landi G Landi MT Lang J Lubiński J Mackie R Malvehy J Martin NG Molven A Montgomery GW van Nieuwpoort FA Novakovic S Olsson H 《Nature genetics》2011,43(11):1108-1113
We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additional 6,426 control subjects from French or British populations, all of whom were genotyped for 317,000 or 610,000 single-nucleotide polymorphisms (SNPs). Our analysis replicated previously known melanoma susceptibility loci. Seven new regions with at least one SNP with P < 10(-5) and further local imputed or genotyped support were selected for replication using two other genome-wide studies (from Australia and Texas, USA). Additional replication came from case-control series from the UK and The Netherlands. Variants at three of the seven loci replicated at P < 10(-3): an SNP in ATM (rs1801516, overall P = 3.4 × 10(-9)), an SNP in MX2 (rs45430, P = 2.9 × 10(-9)) and an SNP adjacent to CASP8 (rs13016963, P = 8.6 × 10(-10)). A fourth locus near CCND1 remains of potential interest, showing suggestive but inconclusive evidence of replication (rs1485993, overall P = 4.6 × 10(-7) under a fixed-effects model and P = 1.2 × 10(-3) under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series. 相似文献
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Cambon-Thomsen A Thorisson GA Mabile L Andrieu S Bertier G Boeckhout M Cambon-Thomsen A Carpenter J Dagher G Dalgleish R Deschênes M di Donato JH Filocamo M Goldberg M Hewitt R Hofman P Kauffmann F Leitsalu L Lomba I Mabile L Melegh B Metspalu A Miranda L Napolitani F Oestergaard MZ Parodi B Pasterk M Reiche A Rial-Sebbag E Rivalle G Rochaix P Susbielle G Tarasova L Thomsen M Thorisson GA Zawati MH Zins M;BRIF workshop group 《Nature genetics》2011,43(6):503-504
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R. Utili A. Di Donato G. Draetta G. Paolisso C. O. Abernathy G. Illiano 《Cellular and molecular life sciences : CMLS》1982,38(7):831-833
Summary
Escherichia coli endotoxin inhibited the fluoride-stimulated adenylate cyclase activity of liver plasma membranes enriched with bile canaliculi. Inhibition was of a mixed competitive and uncompetitive type. This effect, which may result from changes of membrane organization, may have relevance in the understanding of endotoxin-cell membrane interactions. 相似文献
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S-100 protein in cerebral cortex synaptosomes 总被引:4,自引:0,他引:4