Na*-independent binding of [3H] muscimol to a membrane fraction of the brains of normal and dwarf mice

Summary Although their body weights were decreased by about 77% and their brain weights by about 30%, high-affinity [³H] muscimol binding to a cerebral membrane fraction was not altered in hereditary pituitary dwarf mice. Marked changes in the level of pituitary growth-associated hormones do not appear to be associated with a change in cerebral GABA-receptors.Supported by a UNESCO/IBRO Fellowship. Permanent address: Semmelweis University Medical School, 1st Institute of Biochemistry, Budapest, Hungary.     

Na+ independent binding of [3H] muscimol to a membrane fraction of the brains of normal and dwarf mice

Although their body weights were decreased by about 77% and their brain weights by about 30%, high-affinity [3H] muscimol binding to a cerebral membrane fraction was not altered in hereditary pituitary dwarf mice. Marked changes in the level of pituitary growth-associated hormones do not appear to be associated with a change in cerebral GABA-receptors.     

Binding of [3H]GABA and [3H]muscimol to subcellular particles of a neurone-enriched culture of mouse brain

Summary Binding of [³H]GABA and [³H]muscimol, indicative of GABA-receptors, has been demonstrated in a neurone-enriched culture of embryonic mouse brain using a ligand-binding technique. Evidence is provided for the existence of different populations of GABA-receptors.This study was supported by C.N.R.S., ATP N^o 3356 and by Commissariat à l'Energie Atomique, Departement of Biologie. Thanks are due to Mlle Marie-Anne Frenkel for her excellent technical assistance.     

Dehydration of the brain by intra-peritoneal injections of hyper-osmotic solutions of γ-aminobutyric acid anddl-α-alanine

Résumé Utilisant une technique radioactive avec le³HOH, nous avons montré que les injections i.p. des solutions hyperosmotiques de l'acide-aminobutyrique et dedl--alanine, deshydratent de manière significative les cerveaux des souris.

---

---

This study was supported by the U.S.P.H.S.     

Motilities of isolated and aggregated mice; A difference in ultradian rhythmicity

Summary Isolated mice display higher locomotor activity and greater sensitivity to d-amphetamine than aggregated mice. Ultradian motility rhythms can be shown to differ both quantitatively and qualitatively between isolated and aggregated mice.This study was supported in part by Centro Ramón y Cajal and Fundación Juan March. Present address of F.V.D. is Centre de Neurochimie, 11 rue Humann, F-67085 Strasbourg Cédex (France).