Threshold for eliciting the hippocampal theta-rhythm by electrical stimulation in tegmentum and hypothalamus during cortical spreading depression in rats

Zusammenfassung Vorübergehende ein- oder beidseitige funktionelle Dekortikation mittels «spreading depression» ergibt bei elektrischer Reizung des Tegmentums oder Hypothalamus einen Schwellenanstieg des Weckeffektes. Die Reaktionsunterschiede der Hirnteile werden über die theta-Aktivität im Hippokampus beurteilt.     

Lipogenesis in rats adapted to intermittent starvation or continuous underfeeding

Zusammenfassung Albinoratten, bei denen zwischen die Fütterungstage 1–2tägige Hungerperioden eingesetzt wurden, zeigten nach 3 Wochen eine wesentlich erhöhte Inkorporation von 1-C¹⁴-Acetat in die Fettsäuren der Leberschnitte. Selbst bei Herabsetzung der Kalorienzufuhr um ca. 50% stieg hier, im Gegensatz zu kontinuierlich unterernährten Tieren, der prozentuale Körperfettgehalt. Die Resultate sprechen für eine Steigerung der Lipogenese.     

Über die tuberkulostatische Aktivität von 2,5-Bis-(aminooxymethyl)-3,6-diketopiperazin,eines Umwandlungsproduktes des Cycloserins

Summary It has been ascertained that racemic 2,5-bis-(aminooxymethyl)-3,6-diketopiperazine, being a transformation product ofD,L-cycloserine, possesses the same effect againstMycobacterium tuberculosis asD,L-cycloserine itself.     

Derivate des 6,11-Dihydrodibenz(b,e)thiepins,eine neue Gruppe von psychotropen Substanzen

Summary Reactions of phthalide and 6-chlorophthalide with sodium salts of thiophenols gaveo-(phenylmercaptomethyl)benzoic acids (III), which were cyclized by the action of polyphosphoric acid to 6, 11-dihydrodibenz(b,e)-thiepin-11-ones (1). These ketones were treated with 3-di-methylaminopropylmagnesium chloride and other basic Grignard reagents and the products (IV) dehydrated to a series of 11-(aminoalkylidene)-6,11-dihydrodibenz(b,e)-thiepins (V), the hydrochlorides of which show psychotropic activity.

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6. Mitt. Synthetische Ataractica, 5. Mitt. siehe eskoslov. farm.11, im Druck (1962).     

Erycanosid,ein neues Herzglycosid ausErysimum canescens Roth

Summary By application of the counter-current method on extracts ofErysimum canescens Roth, four new crystalline glycosides have been isolated besides of Helveticoside and Erysimoside. The structure of one of them, named Erycanoside, has been determined as Strophanthidin--2-desoxy-D-glucosido-glucoside.     

Somatostatin and 3-oxy-methyl-D-glucose (3-OMG) uptake in isolated chicken intestinal epithelial cells

Summary The direct effect of somatostatin on the absorption of 3-oxymethylglucose in epithelial cells isolated from the small intestine of chicken was studied. The presence of somatostatin in the incubation medium at concentrations of 3.5×10^–8 M and 7×10^–8 M produced significant dose-dependent increases in the accumulation of sugar in the enterocytes. This effect might be due to an increase in the cell membrane permeability caused by hormone action.     

Behaviour ofDrosophila melanogaster is affected by drugs

Summary Reserpine, colchicine and Rb⁺ ions exerted specific effects on sexual behaviour and locomotor activity of the fruit fly. Neuroleptics and antidepressants were inactive.