ObjectARX技术在电网CAD中的应用

介绍了面向对象的设计思想和对象的抽象机理在电网CAD（PWCAD）系统中的应用以及ObjectARX编程技术。通过分析电网结构的知识特点入手，阐述了通过利用AutoCAD核心数据库的开放结构和ObjectARX提供的基类及类的继承、派生机制定义电力系统专业对象的过程，以及建模系统的数据交换技术，并给出了电力系统中元件类的具体定义方法，由此建立了PWCAD的对象模型。实现了电网CAD与外部数据库之间的数据交换，即图形数据库的一体化。     

渠道管理中的厂商与分销商的博弈分析

分销渠道管理中生产厂商与分销商的良好合作是进行优势互补、提高渠道竞争力和适应市场变化的有效手段。通过对生产厂商与分销商合作交易特征介绍和交易条件的假设，基于相互之间合作的关系建立混合博弈模型，并进行分析，找出影响双方合作关系的因素和实行稳定作的条件；然后，进一步对生产厂商与分销商的长期合作进行有限次重复博弈分析，找出影响双方合作关系的条件，最后，根据推论分析的结果，指出生产厂商与分销商建立良好的合作关系应采用的策略。     

体育教学中实施素质教育途径的初探

根据素质教育的基本特征和学校体育教学的目的任务 ,本文分析了在体育教学中实施素质教育的必要性和高层次性 ,指出了体育教学中存在的与素质教育不相适应的诸多弊端 ,以及如何进行体育教学改革的基本思想和对策     

论城市居民假日健身游

从城市居民的旅游和体育健身两方面出发，对假日体育旅游健身产品的开发途径，方法进行论述，深入分析了新产品开发的必要性，迫切性，提出了体育旅游健身产品开发的具体内容，同时论证了其开发的可行性。     

Effect of New O-Superfamily Conotoxin on Voltage-Activated Currents of Hippocampal Neurons

The effects of a new O-superfamily conotoxin, SO3, on sodium current (INa), transient A-type potassium currents (IA), and delayed rectified potassium currents (IK), were examined in cultured rat hippocampal neurons using the whole-cell patch clamp technique. Addition of SO3 caused a concentration-dependent, rapidly developing, and reversible inhibition of voltage-activated currents. The IC50 values for the blockage of INa, IA, and IK were calculated as 0.49, 33.9, and 7.6 μmol/L, respectively. The determined Hill coefficients were 1.7, 0.6, and 1.2, respectively. These results indicate that SO3 can selectively inhibit neuronal sodium and potassium currents.     

Systems Thinking and Scenario Planning: Application in the Clothing Sector

Industrial sectors that operate in uncertain environments - with demand variability, product seasonality and different industrialisation structures - need studies that enable identification and forecast trends. Therefore, the development of competitiveness extends beyond a company’s individual performance. Collective action, whether toward consumer markets, supplier markets, competitors and substitutes, can reinforce or help reformulate the current practices of an organisation, besides providing better results in the development of strategies and competitive positioning. Thus, clothing, the sector addressed in this work, is characterised by a long, fragmented, heterogeneous production chain, the competitiveness of which is linked to product differentiation. Therefore, the use of systemic approaches to study this sector is effective. In this sense, this research aims at adapting Systems Thinking and Scenario Planning (STSP) so that it supports the development and planning process in a given sector. Thus, this research applies STSP adapted to an analysis of the clothing sector in the northern region of Rio Grande do Sul State, Brazil. As a result, in academic terms, this research proposed and validated a method for analysing industrial sectors of the clothing industry. In the sectoral context, this research identified elements that leverage the sector’s competitiveness, besides generating knowledge and learning aimed at strengthening the sectoral structure identified, and fostering the formation of a new clothing cluster.     

Development and pathologies of the arterial wall

Arteries consist of an inner single layer of endothelial cells surrounded by layers of smooth muscle and an outer adventitia. The majority of vascular developmental studies focus on the construction of endothelial networks through the process of angiogenesis. Although many devastating vascular diseases involve abnormalities in components of the smooth muscle and adventitia (i.e., the vascular wall), the morphogenesis of these layers has received relatively less attention. Here, we briefly review key elements underlying endothelial layer formation and then focus on vascular wall development, specifically on smooth muscle cell origins and differentiation, patterning of the vascular wall, and the role of extracellular matrix and adventitial progenitor cells. Finally, we discuss select human diseases characterized by marked vascular wall abnormalities. We propose that continuing to apply approaches from developmental biology to the study of vascular disease will stimulate important advancements in elucidating disease mechanism and devising novel therapeutic strategies.     

Protease-activated-receptor-2 affects protease-activated-receptor-1-driven breast cancer

Mammalian protease-activated-receptor-1 and -2 (PAR₁ and PAR₂) are activated by proteases found in the flexible microenvironment of a tumor and play a central role in breast cancer. We propose in the present study that PAR₁ and PAR₂ act together as a functional unit during malignant and physiological invasion processes. This notion is supported by assessing pro-tumor functions in the presence of short hairpin; shRNA knocked-down hPar2 or by the use of a truncated PAR₂ devoid of the entire cytoplasmic tail. Silencing of hPar2 by shRNA-attenuated thrombin induced PAR₁ signaling as recapitulated by inhibiting the assembly of Etk/Bmx or Akt onto PAR₁-C-tail, by thrombin-instigated colony formation and invasion. Strikingly, shRNA-hPar2 also inhibited the TFLLRN selective PAR₁ pro-tumor functions. In addition, while evaluating the physiological invasion process of placenta extravillous trophoblast (EVT) organ culture, we observed inhibition of both thrombin or the selective PAR₁ ligand; TFLLRNPNDK induced EVT invasion by shRNA-hPar2 but not by scrambled shRNA-hPar2. In parallel, when a truncated PAR₂ was utilized in a xenograft mouse model, it inhibited PAR₁–PAR₂-driven tumor growth in vivo. Similarly, it also attenuated the interaction of Etk/Bmx with the PAR₁-C-tail in vitro and decreased markedly selective PAR₁-induced Matrigel invasion. Confocal images demonstrated co-localization of PAR₁ and PAR₂ in HEK293T cells over-expressing YFP-hPar2 and HA-hPar1. Co-immuno-precipitation analyses revealed PAR₁-PAR₂ complex formation but no PAR₁-CXCR4 complex was formed. Taken together, our observations show that PAR₁ and PAR₂ act as a functional unit in tumor development and placenta-uterus interactions. This conclusion may have significant consequences on future breast cancer therapeutic modalities and improved late pregnancy outcome.     

Exploring the Potency of Rich Pictures in a Systemic Lean Intervention Process

Systemic Practice and Action Research - This paper explores the usefulness of rich pictures as a method in Systemic Lean Intervention (SLI) process. It combines Lean and Systems Thinking analytical...     

Debunking material induction

In this paper, we present an explanatory objection to Norton's material theory of induction, as applied to predictive inferences. According to the objection we present, there is an explanatory disconnect between our beliefs about the future and the relevant future facts. We argue that if we recognize such a disconnect, we are no longer rationally entitled to our future beliefs.