Penetration of oximes across the blood-brain barrier. A histochemical study of the cerebral cholinesterases reactivation.

The comparison of the effects of 4 oximes upon the cerebral cholinesterases reactivation after intoxication with paraoxon shows that the best results are obtained with toxogonine and 1574 [(carbaldoxime-4 pyridinium)-1(methyl-1 imidazolium-3)-3 propane]. The reactivation power of this latter compound seems due to the ease with which it can pass through the blood-brain barrier.     

Octopus chromatophores accumulate nickel

Summary Microprobe analysis of the pigment granules in the superimposed chromatophore layers ofOctopus vulgaris reveal rising amounts of calcium, nickel and sulfur as the size and electron-density of the granules increases. The colours, associated with these increases, shift from yellow/orange to red and finally black.This work was prepared while A.P. was on study leave in Germany supported by the Deutscher Akademischer Austauschdienst.     

Effect of des-Tyr1-gamma-endorphin on serotonin metabolism in rat brain regions

Intracerebroventricular (i.c.v.) administration of des-Tyr1-gamma-endorphin (0.1 and 1.0 microgram) caused a decrease of the serotonin (5-HT) concentration of the hippocampus. The concentration of 5-HIAA and the pargyline-induced alterations in 5-HT and 5-HIAA were not affected. No effects were noticed in other brain regions.