Estrogen receptor in uteri of mice of different H-2 genotypes.

A relationship between the amount of available estradiol receptors in uteri of inbred mice and their H-2 genotype is suggested by study in congenic animals.     

Radiation-released histamine in the rhesus monkey as modified by mast-cell depletion and antihistamine

Summary 4000 rads of mixed gamma neutron radiation administered to rhesus monkeys released a significant amount of histamine into their circulation. When the monkeys were treated with a mast-cell histamine depleter (compound 48/80) for 4 days and then irradiated, no increase in circulating histamine was seen. When 48/80 was given 20 min after irradiation, only a slight increase in histamine was seen, indicating that 4000 rads had released most of the mast-cell histamine.     

Autoradiographic studies on RNA synthesis and transport in the Salivary gland ofLygaeus sp. (Hemiptera-Lygaeidae)

Summary Autoradiographic studies using³H-uridine in the salivary gland of adultLygaeus sp. were carried out. The gland cell nuclei, particularly the multiple nucleoli, are the sites of incorporation of the label exhibiting RNA synthesis. The labelled molecules (RNA) are transported to the cell cytoplasm and then into the gland lumen in which no turnover of the radioactivity is observed.I am grateful to my teacher, Prof. P. S. Ramamurty, School of Life Sciences, University of Hyderabad, for his constant inspiration. Grateful acknowledgement is made to Prof. J. P. Thapliyal, Dept of Zoology, B. H. U. for encouragement and to Dr Om Prakash, Dept of Biochemistry, B. H. U. for his valuable criticism.     

Human leukocyte and fibroblast interferons are structurally related

The coding sequences of the dDNAs of cloned human leukocyte interferon I and human fibroblast interferon show homologies of 45% at the nucleotide and 29% at the amino acid level. We conclude that the two genes were derived from a common ancestor.     

Threo-3,4-Dihydroxyphenylserine,a poor source of noradrenaline in the rat

Résumé Chez le rat, les injections dedl-thréo-3,4-dihydroxyphénylsérine, un précurseur pharmacologique synthétique de la noradrénaline, provoquent une conversion de moins de 1% au 4-hydroxy-3-méthoxyphényl-glycol, le métabolite urinaire majeur de la noradrénaline dans cette espèce. Un nouveau cheminement qui entraîne une coupure latérale de la chaîne prit environ 10% de la dose et un autre 10% fût excrété comme un amino-acideO-méthylé; le sort de quelque 80% est inconnu.     

(−)-Δ8-tetrahydrocannabinol: Two novel in vitro metabolites

Zusammenfassung (–)-⁸-Tetrahydrocannabinol ist einer der Aktivstoffe in Marihuana (Cannabis sativa L.). Inkubation dieser Verbindung mit der überstehenden Zentrifugationsfraktion (9000g) aus männlicher Hundeleber ergab zwei Hauptmetaboliten, welche durch Massenspektrometrie und Kernresonanzspektroskopie identifiziert wurden. Den beiden Verbindungen werden die Strukturen des 1-Hydroxy-⁸-tetrahydrocannabinols und des 3-Hydroxy-⁸-tetrahydrocannabinols zugeordnet.