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881.
The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle 总被引:37,自引:0,他引:37
The ability of insulin to promote the phosphorylation of some proteins and the dephosphorylation of others is paradoxical. An insulin-stimulated protein kinase is shown to activate the type-1 protein phosphatase that controls glycogen metabolism, by phosphorylating its regulatory subunit at a specific serine. Furthermore, the phosphorylation of this residue is stimulated by insulin in vivo. Increased and decreased phosphorylation of proteins by insulin can therefore be explained through the same basic underlying mechanism. 相似文献
882.
A small RNA accumulating late in adenovirus infection is required for efficient protein synthesis, although not specifically for the translation of viral proteins. This RNA maintains the activity of an initiation factor catalysing the earliest step of polypeptide chain initiation. 相似文献
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Michael A. B. Deakin 《Archive for History of Exact Sciences》1985,33(4):307-319
Euler invented integral transforms in the context of second order differential equations. He used them in a fragment published in 1763 and in a chapter of Institutiones Calculi Integralis (1769). In introducing them he made use of earlier work in which a concept akin to the integral transform is implicit. It would, however, be reading too much into that earlier work to see it as contributing to the theory of the integral transform. Other work sometimes cited in this context in fact has different concerns. 相似文献
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Summary A communication signal in an African freshwater electric fish, its pulse-like Electric Organ Discharge (EOD), was investigated in order to determine whether inter- or intraindividual variability of the EOD waveform provides a putative cue for communication, in addition to the electric cues already identified. In contrast to an individual's highly stereotyped EODs showing extremely low variation (fig. 1), variability between individuals was considerable (fig. 2). The dependence of an individual's EOD duration on temperature was weak with a Q10 of close to 1.5. In none of four quantitative EOD waveform measures can a sexual dimorphism be discerned (table).Gnathonemus petersii very likely relies on mechanisms other than discrimination of intraspecific EOD waveforms for mate recognition. 相似文献
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Production of 'hybrid' antibiotics by genetic engineering 总被引:30,自引:0,他引:30
D A Hopwood F Malpartida H M Kieser H Ikeda J Duncan I Fujii B A Rudd H G Floss S Omura 《Nature》1985,314(6012):642-644
The recent development of molecular cloning systems in Streptomyces has made possible the isolation of biosynthetic genes for some of the many antibiotics produced by members of this important genus of bacteria. Such clones can now be used to test the idea that novel antibiotics could arise through the transfer of biosynthetic genes between streptomycetes producing different antibiotics. The likelihood of a 'hybrid' compound being produced must depend on the substrate specificities of the biosynthetic enzymes, about which little is known. In attempts to demonstrate hybrid antibiotic production, we therefore began with strains producing different members of the same chemical class of compounds in order to maximize the chance of success. Here we report the production of novel compounds by gene transfer between strains producing the isochromanequinone antibiotics actinorhodin, granaticin and medermycin. These experiments were made possible by the recent cloning of the whole set of genes for the biosynthetic pathway of actinorhodin from Streptomyces coelicolor A3(2) (ref. 8). We believe that this represents the first report of the production of hybrid antibiotics by genetic engineering. 相似文献