Teratogenic effects of the amino acid leucine in the chicken

Zusammenfassung Leucin wurde in einer Dosis von 0,2 ml einer 1%igen Lösung im Amnion von 9 Tage bebrüteten Hühnereiern injiziert. Morphologische Anomalien mit abnormen Funktionen, meistens in den Beinen und der Nackenregion, wurden beobachtet, während Röntgen-Aufnahmen Stellungsanomalien in Gelenken der Extremitäten und der Halswirbel zeigten.

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This work was aided by grants from Sigrid Juselius Foundation.     

Zum Proliferations-Stoffwechsel der Rattenleber nach Teilhepatektomie. Autoradiographische Untersuchungen mit3H-Cytidin,-Phenylalanin und -Thymidin

Summary During the first wave of parenchymal liver regeneration in adult rats after partial hepatectomy, the cellular synthesis and migration of RNA and the metabolism of protein were studied by autoradiography following an injection of³H-cytidine or³H-l-phenylalanine and double injections of 1 of these precursors +³H-thymidine. The following results were obtained: the synthesis and migration of RNA and the metabolism of protein are enhanced under these conditions of proliferation. In spite of this, the relation of metabolic activity in nucleolus, karyoplasm and cytoplasm remains constant. By double injection techniques it is proved that no differences exist in migration of RNA into the cytoplasm and cytoplasmic protein synthesis between cells with or without DNA synthesizing nuclei.

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Mit Unterstützung der Deutschen Forschungsgemeinschaft.     

A rapid method of following the spontaneous regression of experimental leukemias

Summary Transplantation of virus and chemically induced leukemias from C3H/He-mgxAKR/F₁ hybrid mice into C3H/He-mg males induced leukemias in the latter, which was followed by a spontaneous regression of the disease within a few days. The regression of leukemia could easily be followed by measuring the changes in the pyruvate kinase activity of para-aortic lymph node cells.     

Partial purification and some characteristics of hamster molar alkaline phosphatase

Summary A rapid 3-step method is given to purify partially hamster molar alkaline phosphatase. Molecular weight was 50,200 and isoelectric point 3.7. The alkaline phosphatases in the mesenchymal and ectodermal parts of the tooth are probably identical.     

Lymphostatic Retinal Haemangiopathy

Zusammenfassung Verschluss der zervikalen Lymphbahnen führt zu einer lymphostatischen, retinalen Hämangiopathie mit Verdickung und Strukturveränderung der Basalmembranen.     

Effect of long-term fenfluramine treatment on drug-metabolism in rat

Zusammenfassung Nachweis, dass Fenfluramin in Dosen von 25 und 50 mg/kg p.o. Arzneimittel abbauende Enzyme stimuliert und die Cytochromen b₅ und P-450 in der Rattenleber vermehrt. Der induzierende Effekt ist bereits nach 3 Wochen maximal.     

Zum Vorkommen neuraminsäurehaltiger Glykoproteide

Summary The results are reported of investigations on the content of neuraminic acid in serum of 15 animal species, pure serum protein fractions, fibrin, haemoglobin, urine, liquor, saliva and milk.     

The effect of splenectomy on the development of experimental pyelonephritis

Summary Although an unusually high incidence of a variety of infections in infants who had undergone splenectomy has been reported by a number of investigators the subject remains somewhat controversial. In the present experiments the role of the spleen in the protection of rats against experimentally induced hematogenous pyelonephritis was studied. The results of this study suggest that the spleen has an important preventive function against bacterial infection.