(R)-(Z,E)-9,11-octadecadien-13-olide: An intriguing lactone fromHeliconius pachinus (Lepidoptera)

Summary A fourteen-membered lactone,(R)-(Z,E)-9,11-octadecadien-13-olide, was isolated from extruded abdominal glands of a Neotropical, nymphalid butterfly,Heliconius pachinus (Lepidoptera). This compound was obtained from mature adults of both sexes, but was not detected in young adults or pupae.     

The diversity of molecular motors: an overview

Rapid progress has recently been made in the identification and characterization of a large number of kinesin and myosin motor proteins. Recent work has uncovered roles for these motors in processes such as vesicle trafficking, cytoskeletal organization, and chromosome movements, to name a few. A series of reviews describing some of the significant advances in our understanding of the structure and function of myosins and kinesins is presented.     

Isotopic portrayal of the Earth's upper mantle flow field

It is now well established that oceanic plates sink into the lower mantle at subduction zones, but the reverse process of replacing lost upper-mantle material is not well constrained. Even whether the return flow is strongly localized as narrow upwellings or more broadly distributed remains uncertain. Here we show that the distribution of long-lived radiogenic isotopes along the world's mid-ocean ridges can be used to map geochemical domains, which reflect contrasting refilling modes of the upper mantle. New hafnium isotopic data along the Southwest Indian Ridge delineate a sharp transition between an Indian province with a strong lower-mantle isotopic flavour and a South Atlantic province contaminated by advection of upper-mantle material beneath the lithospheric roots of the Archaean African craton. The upper mantle of both domains appears to be refilled through the seismically defined anomaly underlying South Africa and the Afar plume. Because of the viscous drag exerted by the continental keels, refilling of the upper mantle in the Atlantic and Indian domains appears to be slow and confined to localized upwellings. By contrast, in the unencumbered Pacific domain, upwellings seem comparatively much wider and more rapid.     

C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a

Complement-derived anaphylatoxins regulate immune and inflammatory responses through G-protein-coupled receptor (GPCR)-mediated signalling. C5L2 (also known as GPR77) is a relatively new GPCR thought to be a non-signalling receptor binding to C5a, on the basis of sequence information and experimental evidence. Here we show, using gene targeting, that C5L2 is required to facilitate C5a signalling in neutrophils, macrophages and fibroblasts in vitro. Deficiency of C5L2 results in reduced inflammatory cell infiltration, suggesting that C5L2 is critical for optimal C5a-mediated cell infiltration in certain in vivo settings. C5L2 is also involved in optimizing C3a-induced signals. Furthermore, like mice incapable of C3a/complement 3a receptor (C3aR) signalling, C5L2-deficient mice are hypersensitive to lipopolysaccharide (LPS)-induced septic shock, show reduced ovalbumin (OVA)-induced airway hyper-responsiveness and inflammation, and are mildly delayed in haematopoietic cell regeneration after gamma-irradiation. Our data indicate that C5L2 can function as a positive modulator for both C5a- and C3a-anaphylatoxin-induced responses.