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91.
介绍用计算机软件产生正弦稳态扫频信号的编程方法。通过对D/A变换与A/D采集的同步输出可以获得不同频率量程和设定电压的扫频输出 相似文献
92.
无失真信息隐藏技术,可以使一个原始图像在经过藏入、取出秘密信息之后依然完整存储,为了进一步改进压缩域图像信息隐藏方法,文中提出了一种基于混合基底记法的无失真图像信息隐藏技术,主要做了以下工作:给出了应用的VQ编码、SMVQ编码的理论基础;完成了基于混合基底记法的信息隐藏的设计;应用6张512×512像素的灰度图片完成了实验结果验证。实验结果表明:新方法与传统的基于边缘匹配矢量量化编码方法相比,减少了秘密信息嵌入时间,提高了秘密信息嵌入容量。 相似文献
93.
Cho YS Chen CH Hu C Long J Ong RT Sim X Takeuchi F Wu Y Go MJ Yamauchi T Chang YC Kwak SH Ma RC Yamamoto K Adair LS Aung T Cai Q Chang LC Chen YT Gao Y Hu FB Kim HL Kim S Kim YJ Lee JJ Lee NR Li Y Liu JJ Lu W Nakamura J Nakashima E Ng DP Tay WT Tsai FJ Wong TY Yokota M Zheng W Zhang R Wang C So WY Ohnaka K Ikegami H Hara K Cho YM Cho NH Chang TJ Bao Y Hedman ÅK Morris AP McCarthy MI;DIAGRAM Consortium;MuTHER Consortium Takayanagi R Park KS Jia W Chuang LM Chan JC Maeda S Kadowaki T Lee JY Wu JY 《Nature genetics》2012,44(1):67-72
We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3. GLIS3, which is involved in pancreatic beta cell development and insulin gene expression, is known for its association with fasting glucose levels. The evidence of an association with T2D for PEPD and HNF4A has been shown in previous studies. KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D. 相似文献
94.
Cho SJ Huh JE Song J Rhee DK Pyo S 《Cellular and molecular life sciences : CMLS》2008,65(20):3290-3303
Ikaros is known as a critical regulator of lymphocyte development. We examined the regulatory role of Ikaros in LPS/IFN-gamma-induced inducible nitric oxide synthase (iNOS) expression by macrophages. Our results showed that IK6 (Ikaros dominant negative isoform) induction increases the iNOS expression. Ikaros DNA binding activity on the iNOS promoter was decreased, and a mutation of the Ikaros-binding site on the iNOS promoter resulted in an increase in LPS/IFN-gamma-induced iNOS expression. LPS/IFN-gamma increased the histone (H3) acetylation on the Ikaros DNA binding site. These results suggest that Ikaros acts as a negative regulator on iNOS expression. Treatment with a casein kinase 2 (CK2) inhibitor reversed LPS/IFN-gamma-induced decrease in Ikaros DNA binding activity. Moreover, overexpression of kinase-inactive CK2 decreased iNOS expression and a significant amount of CK2alpha1 translocated into the nucleus in LPS/IFN-gamma-treated cells. Overall, these data indicate that LPS/IFN-gamma decreases the Ikaros DNA binding activity via the CK2 pathway, resulting in an increase of iNOS expression. 相似文献
95.
1. Introduction The problem of determining an optimal tolerance is equivalent to the problem of determining optimal specification limits, since the term tolerance refers to the distance between its lower and upper specification limits. Functional performance and economic considerations are the two primary factors affecting the design of tolerances. A tighttolerance usually implies high manufacturing cost due to additional manufacturing operations, slow processing rates, additional care on part… 相似文献
96.
INTRODUCTIONFungal laccases (benzenediol:oxygen oxidoreductases, EC 1.10.3.2) are multicopper oxidases, capable of reducing oxygen to water and simultaneously involved in oxidation of aromatic hydrogen donors. These enzymes and very similar polyphenol oxidases can be used as free or immobilized type both in water or in some organic solvents for improving several biotechnological processes (Burton etal. 1995; Luterek etal. 1998; Milstein etal. 1993). Of possible applications, the enzyme i… 相似文献
97.
This paper studies a production system where products are produced continuously and whose specification limits are specified for screening inspection. In this paper, we consider dual quality characteristics and different costs associated with each quality characteristic that falls below a lower specification limit or above an upper specification limit. Due to these different costs, the expected total profit will greatly depend on the process parameters, especially a process mean. This paper develops a Markovian-based model for determining the optimum process means with the consideration of dual quality characteristics in a single-stage system. The proposed model is then illustrated through a numerical example and sensitivity analysis is performed to validate the model. The results showed that the optimum process mean for both quality characteristics have a significant effect on the performance of the system. Since the literature survey shows that dealing with multi-quality characteristics is extremely limited, the proposed model, coupled with the Markovian approach, provides a unique contribution to this field. 相似文献
98.
99.
一类高阶非线性系统的零解稳定性 总被引:1,自引:0,他引:1
由Барбащин公式得到的四阶常系数线性系统的Ляпунов函数出发,通过类比法构造了一类四阶非线性系统的Ляпунов函数,并由此得到了这些系统零解的全局渐近稳定性的充分条件 相似文献
100.
Dong-Hyung Cho Tomohiro Nakamura Stuart A. Lipton 《Cellular and molecular life sciences : CMLS》2010,67(20):3435-3447
Mitochondria are highly dynamic organelles that continuously undergo two opposite processes, fission and fusion. Mitochondrial
dynamics influence not only mitochondrial morphology, but also mitochondrial biogenesis, mitochondrial distribution within
the cell, cell bioenergetics, and cell injury or death. Drp1 mediates mitochondrial fission, whereas Mfn1/2 and Opa1 control
mitochondrial fusion. Neurons require large amounts of energy to carry out their highly specialized functions. Thus, mitochondrial
dysfunction is a prominent feature in a variety of neurodegenerative diseases. Mutations of Mfn2 and Opa1 lead to neuropathies
such as Charcot-Marie-Tooth disease type 2A and autosomal dominant optic atrophy. Moreover, both Aβ peptide and mutant huntingtin
protein induce mitochondrial fragmentation and neuronal cell death. In addition, mutants of Parkinson’s disease-related genes
also show abnormal mitochondrial morphology. This review highlights our current understanding of abnormal mitochondrial dynamics
relevant to neuronal synaptic loss and cell death in neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s
disease and Huntington’s disease. 相似文献