Faithful chaperones

This review describes the properties of some rare eukaryotic chaperones that each assist in the folding of only one target protein. In particular, we describe (1) the tubulin cofactors, (2) p47, which assists in the folding of collagen, (3) α-hemoglobin stabilizing protein (AHSP), (4) the adenovirus L4-100 K protein, which is a chaperone of the major structural viral protein, hexon, and (5) HYPK, the huntingtin-interacting protein. These various-sized proteins (102–1,190 amino acids long) are all involved in the folding of oligomeric polypeptides but are otherwise functionally unique, as they each assist only one particular client. This raises a question regarding the biosynthetic cost of the high-level production of such chaperones. As the clients of faithful chaperones are all abundant proteins that are essential cellular or viral components, it is conceivable that this necessary metabolic expenditure withstood evolutionary pressure to minimize biosynthetic costs. Nevertheless, the complexity of the folding pathways in which these chaperones are involved results in error-prone processes. Several human disorders associated with these chaperones are discussed.     

Immune biology of Ag-specific γδ T cells in infections

Accumulating evidence suggests that human γδ T cells act as non-classical T cells and contribute to both innate and adaptive immune responses in infections. Vγ2 Vδ2 T (also termed Vγ9 Vδ2 T) cells exist only in primates, and in humans represent a dominant circulating γδ T-cell subset. Primate Vγ2 Vδ2 T cells are the only γδ T cell subset capable of recognizing microbial phosphoantigen. Since nonhuman primate Vγ2 Vδ2 T cells resemble their human counterparts, in-depth studies have been undertaken in macaques to understand the biology and function of human Vγ2 Vδ2 T cells. This article reviews the recent progress for immune biology of Vγ2 Vδ2 T cells in infections.     

复合土钉墙中搅拌桩对变形及土钉拉力的影响

复合土钉墙中的水泥搅拌桩对于减小基坑水平位移、改善土钉的受力状态有重要作用,但目前对于搅拌桩在复合土钉墙中这一作用的研究多局限在定性探讨,未进行较为量化的分析,在复合土钉墙的设计中也一般将搅拌桩作为安全储备.文中通过对复合土钉墙的有限元分析,对复合土钉墙中不同搅拌桩排数、长度及不同土层情况进行了对比研究.结果表明,设置不同排数的搅拌桩对于复合土钉墙的受力机理、变形特性、土钉拉力大小及分布均有较大影响,1~2排搅拌桩较为合理,过多的搅拌桩排数可能会导致复合土钉墙出现重力式挡墙的受力、变形性态,增加上部土钉的拉力.     

磁带库随机I/O缓冲调度算法的性能

为了提高磁带设备的在线存储效率,提出了一种磁带库缓冲调度算法.该算法采用磁盘驱动器做缓存,将磁带库设备虚拟为逻辑块设备使用.同时,提出了主动写回以及读预取方法,将磁带库的随机读写操作顺序化,以改善系统随机读写性能.文中还对算法性能进行了详细分析,并利用仿真方法对算法进行了测试,结果证明系统集合I/O和单I/O响应时间能够得到明显改善.     

现代网络业务流的几个基本定律

为了采用有物理意义的参数,在多个时间尺度下对现代网络业务流进行建模,考察了网络流量长相关(LRD)的基本特征,提出了业务流中满足的几个基本定律,揭示了在流量中描述LRD定量关系的参数cγ(或cf)、流量聚集级m、平均到达率l之间的基本关系,并通过实际测量的数据加以验证.所提出的定律表明:(1)流量确实存在LRD行为;(2)平均到达率(TCP和IP流等)与参数cγ(或cf)存在一定的统计定量关系.     

相同条件下大样本沥青混合料的疲劳性能

采用一个沥青混合料小梁试件大样本,在相同条件下进行了应变控制疲劳试验研究,分析了沥青混合料试件疲劳寿命、初始模量和累计耗散能的分布规律,探讨了疲劳寿命与初始模量和累计耗散能的关系,以及疲劳寿命、初始模量和累计耗散能与试件空隙率之间的关系.试验结果表明:应变控制疲劳寿命数据的离散性大;沥青混合料的疲劳寿命、累计耗散能和初始模量呈三参数W eibull分布和对数三参数W eibull分布,三参数W eibull分布可以用于分析沥青混合料的疲劳数据;相同条件下,试件的疲劳寿命与初始模量数据线性和对数线性负相关,与累积耗散能数据呈现非常良好的线性正相关,疲劳寿命对数和累积耗散能对数与空隙率负相关性较好;初始模量与空隙率的相关性不明显.文中的研究结果验证和揭示了沥青混合料的应变控制疲劳破坏规律.     

A New Theoretical Framework of Pyramid Markov Processes for Blockchain Selfish Mining

In this paper,we provide a new theoretical framework of pyramid Markov processes to solve some open and fundamental problems of blockchain selfish mining under ...     

Silane as Electrolyte Additives for Lithium Ion Batteries

1 Results In order to overcome the inherent incompatibility of PC with graphite in the lithium ion battery system, improve their electrochemical performance at low temperature,phenyl tris-2-methoxydiethoxy silane (PTMS) has been studied as an additive to the PC-based electrolyte of lithium ion batteries with graphite anode. From the cyclic voltammogram for the graphite anode in the PC-based electrolyte,we find that in the case of the electrolyte without the additive,there is a large irreversible peak ne...     

浅议存款保险制度

阐述了存款保险制度的内涵及其发展,分析了在我国建立显性存款保险制度的意义,给出了我国存款保险制度的框架。     

西湖凹陷西部斜坡带花港组、平湖组储层裂缝发育特征及有效裂缝测井识别

以西湖凹陷西斜坡花港组、平湖组致密砂岩储层为研究对象,通过录井资料分析及岩心和显微薄片观察,研究裂缝的宏观与微观发育特征及其影响因素.结果显示其主要发育层理缝和构造缝.层理缝主要为水平缝和低角度缝,且已被充填;构造缝主要为垂直缝和高角度缝,充填缝和未充填缝各占一半.裂缝的发育受岩性、单层厚度、断裂及地应力场的综合影响....