Structure of furasterin,a chlorinated metabolite from the fungusPhialophora asteris (downson) burge et isaac

Summary Furasterin, 4-chloro-7-hydroxy-5-methoxy-2-methyl-benzofuran, a new naturally occurring mono-chlorinated fungal metabolite was isolated fromPhialophora Asteris (Downson) Burge et Isaac. Its possible relationship with the biosynthetical pathway of the fungitoxic dichlorinated fungal metabolite cryptosporiopsin is discussed.This work was supported by a combined grant from the French C. N. R. S. and the Dutch foundation Z. W. O.     

Strukturspezifischer Abbau von Polypeptid-Metall-Komplexen III 1. Abbau des Ni2+-Angiotensin II-Komplexes durch H2O2 2

Summary The octapeptide Val⁵-Angiotensin II-Asp¹--amide is split into characteristic fragments by hydrogen peroxide, when complexed with Ni²⁺; this degradation does not occur with the Cu²⁺ complex, presumably because an active ternary peroxo complex cannot be formed.     

Enzymhistochemische Untersuchungen an durstaktivierten neurosekretorischen Zellen der Ratte

Summary In hypothalamic neurosecretory nuclei of rats subject to water withdrawl for 1–14 days, a marked increase in the activities of histochemically detected acid phosphatase, thiamine pyrophosphatase and glucose-6-phosphate dehydrogenase is observed. LDH and SDH activities do not change. Two different cell types can be distinguished by means of the acid phosphatase and TPPase reactions.     

Effects of cadmium on the immune system of mice

Summary Chronic oral exposure of mice to Cd⁺⁺ inhibits cell-mediated immunity of delayed type hypersensitivity induced by sheep red blood cells (SRBC). No effect was detected on humoral immune response to SRBC. Spleen cells derived from mice exposed to Cd⁺⁺ showed in vitro enhanced response to T and B cell mitogens. These results demonstrate that Cd⁺⁺ exposure alters the immune system of mice.Dedicated to Prof. Georg Henneberg on the occasion of his 70th anniversary on 12.10.1978.Acknowledgments. Supported by a grant from the Umweltbundesamt. We thank Ms Odenwald, Ms Schulz, Klinikum Steglitz, and Ms Emeis, Robert Koch-Institut Abt. Immunologie, for the excellent technical assistance.     

Neue Substitutionsreaktionen bei Steroiden

Summary The intramolecular substitution of the angular methyl groups in steroids by attack of O-radicals derived from 6-, 11, and 20-alcohols is discussed. Irrespective of their genesis, these radicals abstract a hydrogen atom from one of the said methyl groups, suitably oriented in-position. The C-radicals thus formed give different products depending on the neighbouring groups.It is shown that 20-hydroxy-18-C-radicals combine with iodine atoms, to give 18-iodides which can befurther substituted through radicals to give potential 18-oxo-compounds in high yield. In the case of 20-cyanohydrines, the intramolecular reaction of the 18-C-radical with the cyano groups gives rise to the new 18-cyano-20-oxo-steroids.With 6- and 11-O-radicalssingle substitution in 19-position predominates, since the steric arrangement of the primary product favours the intramolecular ether formation over a second substitution reaction.A general reaction scheme for these transformations is proposed.

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Vorgetragen vonCh. Meystre am 23. 9. 61 anlässlich der Sommerversammlung der Schweiz. Chem. Gesellschaft in Biel (vgl. Chimia15, (1961), im Druck).

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Über Steroide 180. Mitteilung. 179. Mitt. vgl.A. Wettstein, Exper.17, 329 (1961).     

Etude des variations nycthémérales de la filtration glomérulaire chez le rat

Summary Parallel variations in plasma and urine variations of endogenous urea and creatinine level in the rat during 4 consecutive 6-h-long periods permit to evidence urea and creatinine clearance diurnal variations with very significant increase in the 2 nightly periods. The signification of this very large nightly glomerular filtration increase is discussed.     

Circadian rhythm in cerebral blood volume of mouse

Zusammenfassung Mittels I¹³¹ markiertem Human-Serumalbumin wurde das Blutvolumen im Gehirn von Mäusen zu verschiedenen Tageszeiten gemessen und eine circadiane Rhythmik festgestellt. Andauernder Dunkelaufenthalt führt zu erhöhten Werten des Blutvolumens.