Mögliche Beziehungen der optischen Aktivität zum Problem des Alterns

Summary The solubilities and other properties of compounds made by combination of optically active components, e.g. the solubilities of the salts made from the dextro-form of an acid and the dextro- or the laevo-form of a base are in some instancesextremely different. It is a consequence of these differences that in a living organism, containing optically active substance,the degree of optical purity of these substances is of outmost importance. The presence of undesired antipodes of any kind might fundamentally disturb the metabolism. It is also known that living organisms at least partly and continuously produce the optically active substances needed bysynthesis from optically inactive material.A kinetical and thermodynamical study of the conditions under which optically active substances can, with use of optically active catalysers, be synthetized from inactive material, shows that the degree of optical purity of the material synthetized is, even under the most favorable conditions, maximum in the beginning of the synthesis andis bound to decay when the synthesis is, chemically speaking,completed and if the synthetized material is left in contact with the catalyzer. Thus a racemization of the synthetized active material occurs in which the catalyzer which has originally produced this active substance actively accelerates the deterioration of its state of optical purity.The means are discussed by which the organism is able to delay this loss of optical purity; and it is shown that all poosible means to do so are indeed used by the organism. As these means can delay but never completely avoid the decay of optical purity, this decay, even if it be slow, i.e.an ageing of optical purity, is a necessity in the course of the life of a living organism. As a loss of optical purity must disturb the normal metabolism, this must, even if no other events occur, limit the individual life.Experimental evidence which would check the prediction of decay of optical purity with age is incomplete; in several instances, however, the experimental technique permits us to detect and to follow the occurrence of finite small amounts of undesired antipodes, e.g. of some amino acids in the proteins of living organisms.

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Vortrag, gehalten vor der Schweizerischen Gerontologischen Gesellschaft in Basel am 11. Dezember 1954.     

Effect of polyalkyl polyphosphonates on bone development in young rats

Zusammenfassung Es wird gezeigt, dass Knochenentwicklung junger Ratten durch Behandlung mit Polyethylen-Polyphosphonat ohne toxische Wirkung verhindert wird. Die Polyphosphonate wirken direkt auf den Knochen und können eventuell verschiedene klinische Anwendungen finden.

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Supported by Public Health Grant No. GM 17367-01.     

Zur Wirkung von Oxytocin auf einen autorhythmischen glatten Gefässmuskel

Summary The influence of oxytocine on the spontaneously contractile portal vein of the rat has been investigated. This octapeptide decreases the active tension and abolished it completely at a concentration of 5×10^–7g/ml. The effect is not caused by an adrenergic mechanism but by a direct action on the smooth muscle cell.