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Complete structure and expression in transfected cells of high affinity IgE receptor 总被引:57,自引:0,他引:57
The high-affinity receptor for immunoglobulin E, Fc epsilon RI, is found exclusively on mast cells and basophils. When multivalent allergens bind to the receptor-bound IgE, the consequent aggregation of the receptors leads to the release of mediators responsible for allergic symptoms. In rodents Fc epsilon RI is a tetrameric complex of non-covalently attached subunits: one IgE-binding alpha subunit, one beta subunit and a dimer of disulphide-linked gamma subunits. Complementary DNA encoding the alpha and the beta subunits has recently been isolated, but expression of IgE-binding by transfected cells has not yet been achieved. Here we report the cloning of cDNA for the gamma subunit, and propose a model for the alpha beta gamma 2 tetramer which accounts for many of the structural features of the receptor. The rodent receptor on the surface of COS 7 cells was expressed only when the cDNAs for all three subunits were cotransfected. Successful expression of human IgE receptors should now be possible, eventually to permit the detailed analysis of the human IgE-receptor interaction and assist the search for therapeutically effective inhibitors. 相似文献
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给出了利用单片机及TM8880双音多频(DTMF)编、解码电路构成的智能控制系统,这套系统能够通过电话网提供交互式远程控制。 相似文献
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Peptide chemotaxis in E. coli involves the Tap signal transducer and the dipeptide permease 总被引:29,自引:0,他引:29
Bacterial chemotaxis provides a simple model system for the more complex sensory responses of multicellular eukaryotic organisms. In Escherichia coli, methylation and demethylation of four related membrane proteins, the methyl-accepting chemotaxis proteins (or MCPs), is central to chemotactic sensing and signal transduction. Three of these proteins, Tar, Tsr and Trg, have been assigned specific roles in chemotaxis. However, the role of the fourth MCP, Tap, has remained obscure. We demonstrate here that Tap functions as a conventional signal transducer, enabling the cell to respond chemotactically to dipeptides. This provides the first evidence of specific bacterial chemotaxis towards peptides. Peptide taxis requires the function of a periplasmic component of the dipeptide permease. This protein represents the first example of a periplasmic chemoreceptor that does not have a sugar substrate. 相似文献
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R. J. Yu Jacqueline Ragot F. Blank 《Cellular and molecular life sciences : CMLS》1972,28(12):1512-1513
Zusammenfassung Drei Keratinasen die von einem zoophilen Dermatophyten,Trichophyton mentagrophytes, isoliert wurden, haben eine ausgeprägtere hydrolytische Wirkung auf Keratine tierischen Ursprungs als solche menschlicher Herkunft. 相似文献
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