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951.
Temperature is a key factor in controlling the distribution of marine organisms and is particularly important at hydrothermal vents, where steep thermal gradients are present over a scale of centimetres. The thermophilic worm Alvinella pompejana, which is found at the vents of the East Pacific Rise (2,500-m depth), has an unusually broad thermotolerance (20-80 degrees C) as an adult, but we show here that the temperature range required by the developing embryo is very different from that tolerated by adults. Our results indicate that early embryos may disperse through cold abyssal water in a state of developmental arrest, completing their development only when they encounter water that is warm enough for their growth and survival. 相似文献
952.
Satellite measurements indicate that mid-latitude ozone depletion in the Northern Hemisphere spring during 1979-97 was worst over Europe and Russia. Here we show that these longitudinal differences in ozone trends are due to a combination of decadal variations in the circulation and transport of ozone-depleted air from the polar vortex. Any increase in ozone depletion in the polar vortex as a result of future cooling of the stratosphere would therefore be particularly bad over Europe and Russia. 相似文献
953.
Herbig-Haro (HH) objects have been known for 50 years to be luminous condensations of gas in star-forming regions, but their underlying physical nature is still being elucidated. Previously suggested models encompass newborn stars, stellar winds clashing with nebular material, dense pockets of interstellar gas excited by shocks from outflows, and interstellar 'bullets' (ref. 6). Recent progress has been made with the jet-induced shock model, in which material streams out of young stellar objects and collides with the surrounding interstellar medium. A clear prediction of this model is that the most energetic Herbig-Haro objects will emit X-rays, although they have not hitherto been detected. Here we report the discovery of X-ray emission from one of the brightest and closest Herbig-Haro objects, HH2, at a level consistent with the model predictions. We conclude that this Herbig-Haro object contains shock-heated material located at or near its leading edge with a temperature of about 106 K. 相似文献
954.
Magnetic carbon 总被引:9,自引:0,他引:9
Makarova TL Sundqvist B Höhne R Esquinazi P Kopelevich Y Scharff P Davydov VA Kashevarova LS Rakhmanina AV 《Nature》2001,413(6857):716-718
The discovery of nanostructured forms of molecular carbon has led to renewed interest in the varied properties of this element. Both graphite and C60 can be electron-doped by alkali metals to become superconducting; transition temperatures of up to 52 K have been attained by field-induced hole-doping of C60 (ref. 2). Recent experiments and theoretical studies have suggested that electronic instabilities in pure graphite may give rise to superconducting and ferromagnetic properties, even at room temperature. Here we report the serendipitous discovery of strong magnetic signals in rhombohedral C60. Our intention was to search for superconductivity in polymerized C60; however, it appears that our high-pressure, high-temperature polymerization process results in a magnetically ordered state. The material exhibits features typical of ferromagnets: saturation magnetization, large hysteresis and attachment to a magnet at room temperature. The temperature dependences of the saturation and remanent magnetization indicate a Curie temperature near 500 K. 相似文献
955.
Haemoglobin C protects against clinical Plasmodium falciparum malaria. 总被引:10,自引:0,他引:10
D Modiano G Luoni B S Sirima J Simporé F Verra A Konaté E Rastrelli A Olivieri C Calissano G M Paganotti L D'Urbano I Sanou A Sawadogo G Modiano M Coluzzi 《Nature》2001,414(6861):305-308
Haemoglobin C (HbC; beta6Glu --> Lys) is common in malarious areas of West Africa, especially in Burkina Faso. Conclusive evidence exists on the protective role against severe malaria of haemoglobin S (HbS; beta6Glu --> Val) heterozygosity, whereas conflicting results for the HbC trait have been reported and no epidemiological data exist on the possible role of the HbCC genotype. In vitro studies suggested that HbCC erythrocytes fail to support the growth of P. falciparum but HbC homozygotes with high P. falciparum parasitaemias have been observed. Here we show, in a large case-control study performed in Burkina Faso on 4,348 Mossi subjects, that HbC is associated with a 29% reduction in risk of clinical malaria in HbAC heterozygotes (P = 0.0008) and of 93% in HbCC homozygotes (P = 0.0011). These findings, together with the limited pathology of HbAC and HbCC compared to the severely disadvantaged HbSS and HbSC genotypes and the low betaS gene frequency in the geographic epicentre of betaC, support the hypothesis that, in the long term and in the absence of malaria control, HbC would replace HbS in central West Africa. 相似文献
956.
Thermoelectric materials are of interest for applications as heat pumps and power generators. The performance of thermoelectric devices is quantified by a figure of merit, ZT, where Z is a measure of a material's thermoelectric properties and T is the absolute temperature. A material with a figure of merit of around unity was first reported over four decades ago, but since then-despite investigation of various approaches-there has been only modest progress in finding materials with enhanced ZT values at room temperature. Here we report thin-film thermoelectric materials that demonstrate a significant enhancement in ZT at 300 K, compared to state-of-the-art bulk Bi2Te3 alloys. This amounts to a maximum observed factor of approximately 2.4 for our p-type Bi2Te3/Sb2Te3 superlattice devices. The enhancement is achieved by controlling the transport of phonons and electrons in the superlattices. Preliminary devices exhibit significant cooling (32 K at around room temperature) and the potential to pump a heat flux of up to 700 W cm-2; the localized cooling and heating occurs some 23,000 times faster than in bulk devices. We anticipate that the combination of performance, power density and speed achieved in these materials will lead to diverse technological applications: for example, in thermochemistry-on-a-chip, DNA microarrays, fibre-optic switches and microelectrothermal systems. 相似文献
957.
958.
Analysis of nuclear apoptotic process in a cell-free system 总被引:2,自引:0,他引:2
We report an analysis of the apoptotic process of mouse liver nuclei induced in a cell-free carrot cytosol system by cytochrome
c. Typical characteristics of apoptosis were observed, such as chromatin condensation, margination, apoptotic bodies and DNA
ladders. Furthermore, transmission and scanning electron microscope analysis of the apoptotic nuclei detected chromatin-free
nuclear vesicles before apoptotic bodies appeared at a comparatively late phase. When AC-YVAD-CHO, an inhibitor of caspase
6, was introduced into the system, these vesicles and apoptotic bodies disappeared completely within our study sections. We
confirmed the results using whole-mount electron microscopy, and found that although the nuclear lamina was destroyed early,
the nuclear matrix largely remained intact during the course of apoptosis. The nuclear matrix played an important role in
maintaining the integrity of apoptotic cells and connecting the apoptotic bodies and apoptotic nucleus.
Received 29 September 2000; revised 10 December 2000; accepted 13 December 2000 相似文献
959.
Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells 总被引:41,自引:0,他引:41
Mandelboim O Lieberman N Lev M Paul L Arnon TI Bushkin Y Davis DM Strominger JL Yewdell JW Porgador A 《Nature》2001,409(6823):1055-1060
Natural killer (NK) cells destroy virus-infected and tumour cells, apparently without the need for previous antigen stimulation. In part, target cells are recognized by their diminished expression of major histocompatibility complex (MHC) class I molecules, which normally interact with inhibitory receptors on the NK cell surface. NK cells also express triggering receptors that are specific for non-MHC ligands; but the nature of the ligands recognized on target cells is undefined. NKp46 is thought to be the main activating receptor for human NK cells. Here we show that a soluble NKp46-immunoglobulin fusion protein binds to both the haemagglutinin of influenza virus and the haemagglutinin-neuraminidase of parainfluenza virus. In a substantial subset of NK cells, recognition by NKp46 is required to lyse cells expressing the corresponding viral glycoproteins. The binding requires the sialylation of NKp46 oligosaccharides, which is consistent with the known sialic binding capacity of the viral glycoproteins. These findings indicate how NKp46-expressing NK cells may recognize target cells infected by influenza or parainfluenza without the decreased expression of target-cell MHC class I protein. 相似文献
960.
Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence 总被引:46,自引:0,他引:46
Ohtani N Zebedee Z Huot TJ Stinson JA Sugimoto M Ohashi Y Sharrocks AD Peters G Hara E 《Nature》2001,409(6823):1067-1070