Reduced foetal calcium without skeletal malformations in rats following high maternal doses of a strontium salt

Zusammenfassung nachweis, dass hohe Strontiumkonzentrationen die Kalzifikation der, Knochen neugeborener Mäuse, und diejenige in Knochengewebskulturen hemmen. Im Gegensatz dazu und zu anderen knochenaffinen metallen wirkt Strontiumnitrat in Dosen von25, 50, 100 and 200 mg/kg, verabreicht während des 9. bis 19. Trächtigkeitstages, bei Ratten nicht teratogen.

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We are indebted to Mr.K. L. Murray of the Government Chemist's Laboratory for analyzing tissue samples by atomic absorption spectrophotometry. We are also grateful toDr. R. F. Crampton, Director of BIBRA, for his interest and advice in this work.     

Interaction of inhibitory and excitatory junctional potentials in the control of a myogenic myocardium: the ventricle ofBusycon canaliculatum

Résumé Les auteurs ont étudié, par microélectrode interne, l'interaction entre les potentiels postsynaptique inhibitoire et excitatif dans un myocarde myogénique. Ils ont observé la sommation de ces potentiels et leur action facilitant l'inhibition par hyperpolarization et l'excitation par depolarisation.

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Supported by a grant from the National Institutes of Health, USA (P.H.S. Grant No. 5-R01-NS-08352-03 PHY, from the National Institute of Neurological Diseases and Stroke.)     

Lymphatic metastasis of tumour; persistent transport of cells

Summary A model of lymphatic metastasis established by injecting Walker rat carcinoma cells into the rat footpad was used to study the output of tumour cells from the footpad. The lymphatic efferent from the footpad was cannulated in a group of rats with advanced neoplasm; it was shown that the output of tumou cells was continuou over periods up to 90 min and ranged from 10²–10⁵ cells/min.Acknowledgment. This work was supported by a grant from the National Cancer Institute of Canada to C.R.F. and I.C. We are grateful to Mrs W. Kao and Mr I. Etches for meticulous technical help and to the Photographic Section, Department of Pathology for illustrations. Dr V.S. Gupta of Veterinary Physiology, University of Saskatchewan supplied the tumour for transplantation.