Carboxymethytl Pachymaram Up-Regulates Dendritic Cell＇s Function in Hepatitis B Virus Transgenic Mice

The effect of carboxymethytl pachymaram (CMP) on the function of dendritic cells(DCs) derived from spleens of hepatitis B virus transgenic mice are studied in vitro. The phenotypes of DCs are tested by flow cytometry (FCM), cytokines measured by ELISA. The expression of DCs’ phenotypes in HBV transgenic mice are low (CD80⁺CD11c⁺:59.12±11.53 vs 9.60±4.53, p<0.01; CD80⁺ MHC-II⁺: 44.86±12.31 vs 9.80±5.72, p<0.01, normal mice vs HBV transgenic mice), the ability of DCs stimulating T lymphocytes proliferation decreases (0.37±0.11 vs 0.20±0.11, p<0.05, normal mice vs HBV transgenic mice), levels of IL-12 and IFN-γ decrease whereas the level of IL-10 increases; CMP can enhance DCs’ ability of stimulating T lymphocytes proliferation, facilitate the secretion of IL-12 and IFN-γ, inhibit the secretion of IL-10, thus up regulates DCs function. The results show a good prospective use of CMP on the treatment of chronic hepatitis B. Biography: HOU Anji (1963–), male, Ph.D. candidate, Associate professor, research direction: clinical virology.     

A PLL Clock Frequency Multiplier Using Dynamic Current Matching Adaptive Charge-Pump and VCO Frequency Reuse

A 3.5 times PLL clock frequency multiplier for low voltage different signal （LVDS） driver is presented. A novel adaptive charge pump can automatically switch the loop bandwidth and a voltage-controlled oscillator （VCO） is designed with the aid of frequency ranges reuse technology. The circuit is implemented using 1st Silicon 0.25 μm mixed-signal complementary metal-oxide-semiconductor （CMOS） process. Simulation results show that the PLL clock frequency multiplier has very low phase noise and very short capture time .     

A High-Performance Extraction Method for Public Opinion on Internet

Aiming at the importance of the analysis for public opinion on Internet, the authors propose a high-performance extraction method for public opinion. In this method, the space model for classification is adopted to describe the relationship between words and categories. The combined feature selection method is used to remove noisy words from the original feature space effectively. Then the category weight of words is calculated by the improved formula combining the frequency of words and distribution of words. Finally, the class weights of the not-categorized documents based on the category weight of words are obtained for realizing opinion extraction. Experiment results show that the method has comparatively high classification and good stability.     

Linear Conjugate Boundary Value Problems

We discuss the linear conjugate boundary value problems on the unit circle and the real axis. We obtain some Fredholm integral equations. Using thess equations we discuss the solvable conditions on these problems and we also give a direct method for the extension problems on the real axis.     

Intrusion Detection Method for Program Vulnerability via Library Calls

Library function call sequence is the direct reflection of a program＇s behavior. The relationship between program vulnerability and library calls is analyzed, and an intrusion detection method via library calls is proposed, in which the short sequences of library call are used as signature profile. In this intrusion detection method, library interposition is used to hook library calls, and with the discussion of the features of the library call sequence in detail, an algorithm based on information-theory is applied to determine the appropriate length of the library call sequence. Experiments show good performance of our method against intrusions caused by the popular program vulnerabilities.     

Downside Risk-Aversion Analysis for a Single-Stage Newsvendor Problem

We extend the classical newsvendor problem by introducing a downside risk constraint from the perspective of inventory control. At the beginning of a replenishment period the newsvendor will place an order, then he will review the inventory level at the end of the period. If the inventory level is positive then he will bear the holding cost and if the inventory level is negative then he will bear the backorder cost. The optimal order quantity has a simple form. We analyze the form of the optimal order quan-tity when we restrict that the probability that the cost level is larger than or equal to a fixed cost constant is less than a fixed value of probability. At last, we analyze the case that the fixed cost constant is equal to the expected cost.     

Molecular docking and spectroscopic methods to probe the interaction of acetylgliotoxin and HSA

The interaction between acetylgliotoxin and human serum albumin (HSA) has been studied by spectroscopic method. Acetylgliotoxin quenches the intrinsic fluorescence of HSA in a static quenching procedure. The binding of acetylgliotoxin to HSA causes a slight conformational change of HSA. The binding constants at different temperatures as well as enthalpy change and entropy change, are calculated according to relevant fluorescent data and Van’t Hoff equation. The hydrogen bond is a predominant intermolecular force for stabilizing the complex, which is in conformity with the results of molecular modeling study.     

A fast pseudorandom number generator with BLAKE hash function

This paper presents a fast pseudorandom generation algorithm, which is based on the BLAKE hash function and can pass the random test of the NIST (National Institute of Standards and Technology) Statistical Test Suite. Through theoretical analysis and experimental imitation, our new algorithm is proven to be more secure and efficient than G-SHA1. Simultaneously, we introduce and discuss the BLAKE in detail. Its security shows that can be utilized to generate pseudorandom bit sequences, which the experimental results show the BLAKE hash function has excellent pseudorandomness. Therefore, we believe the BLAKE is one of the most potential candidate algorithms of SHA-3 program.     

Some functions with low differential uniformity

We study the functions with low differential uniformity, and concentrates mainly on the properties of perfect nonlinear (PN) functions, including the properties of the derivative of the components of those functions. Some sufficient and necessary conditions have been explored to judge when a function is a PN function. These conditions may be useful in constructing new PN functions. We also construct some functions with differential 4-uniformity that have rarely been studied in the literature. Some of the constructed functions with differential 4-uniformity have high nonlinearity as well. Finally, a class of functions with differential 4-uniformity which are not extended affine equivalent to any power functions are constructed.     

Types and biotic successions of Ordovician reefs in China

Ordovician reefs are located in the South China,Tarim,and North China blocks,in low-latitude epicontinental marine regions and mostly consist of large-scale carbonate platforms.During the Paleozoic,faunal radiation reef biota diverged and thrived in diverse paleogeographic settings.Algal reefs of the Early Ordovician,Calathium-lithistid sponge-algal reefs of the late Early Ordovician to early Middle Ordovician,and coral-stromatoporoid-algal reefs of the early Late Ordovician,indicate change from Cambrian to Paleozoic biota.Coral-stromatoporoid-algal reefs were the basic communities after 100 Ma.The macroevolution of biotic struc-tures generally shows increased complexity;the evolution of China’s reef biota parallels that worldwide.Important aspects are:(1) The Calathium-algal reefs from the early Tremadocian Nantzinkuan Formation,Zhangjiajie,western Hunan are the pioneer reefs,and the Darriwillian Yijianfang Formation,Bachu are the relic reefs.(2) The bryozoan-dominated reefs of the late Tremadocian Fenhsiang Formation,Middle Yangtze Platform are unique.(3) The early coral-stromatoporoid-algal reefs are highly restricted in China.(4) The algal reefs from the latest Katian on the western margin of the Yangtze Platform,represent an abnormal reef-building environment during the initial stages of Gondwanan glaciations.