排序方式: 共有27条查询结果,搜索用时 0 毫秒
11.
Shamita Dutta Gupta 《宁夏大学学报(自然科学版)》2014,(4):304-306
讨论了寿险保单贴现作为投资产品的市场价格风险.用市场价格风险作为投资保单市场的参考,讨论如何选择保单等.事实上,市场价格风险相对较低,可能是最近几年寿险贴现市场下降的原因之一. 相似文献
12.
13.
14.
Hemen Dutta 《南京大学学报(自然科学版)》2011,(1)
本文研究n-范空间的一些性质并构作非标准n-范的若干例子.然后应用n-范概念去引进对任意序列空间以构造序列空间的想法.最后还研究关于诸如线性,范数存在性以及条件完备性等的一些平常事实的构造空间. 相似文献
15.
16.
日历年效应有其经济直观性,尤其是对于那些宏观经济因素对损失索赔有重要影响的业务领域,如工人赔偿.本文利用模拟方法比较了链梯法与日历年模型.假定索赔额遵循日历年模型给出的过程,然后模拟随机索赔额.根据模拟索赔额,使用日历年模型和链梯法计算赔款准备金,并对结果进行了比较. 相似文献
17.
P Dutta G Courties Y Wei F Leuschner R Gorbatov CS Robbins Y Iwamoto B Thompson AL Carlson T Heidt MD Majmudar F Lasitschka M Etzrodt P Waterman MT Waring AT Chicoine AM van der Laan HW Niessen JJ Piek BB Rubin J Butany JR Stone HA Katus SA Murphy DA Morrow MS Sabatine C Vinegoni MA Moskowitz MJ Pittet P Libby CP Lin FK Swirski R Weissleder M Nahrendorf 《Nature》2012,487(7407):325-329
During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaques in the arterial wall and cause their rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a high risk of recurrent events for unknown reasons. Here we show that the systemic response to ischaemic injury aggravates chronic atherosclerosis. After myocardial infarction or stroke, Apoe-/- mice developed larger atherosclerotic lesions with a more advanced morphology. This disease acceleration persisted over many weeks and was associated with markedly increased monocyte recruitment. Seeking the source of surplus monocytes in plaques, we found that myocardial infarction liberated haematopoietic stem and progenitor cells from bone marrow niches via sympathetic nervous system signalling. The progenitors then seeded the spleen, yielding a sustained boost in monocyte production. These observations provide new mechanistic insight into atherogenesis and provide a novel therapeutic opportunity to mitigate disease progression. 相似文献
18.
Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia 总被引:8,自引:0,他引:8
19.
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project 总被引:2,自引:0,他引:2
ENCODE Project Consortium Birney E Stamatoyannopoulos JA Dutta A Guigó R Gingeras TR Margulies EH Weng Z Snyder M Dermitzakis ET Thurman RE Kuehn MS Taylor CM Neph S Koch CM Asthana S Malhotra A Adzhubei I Greenbaum JA Andrews RM Flicek P Boyle PJ Cao H Carter NP Clelland GK Davis S Day N Dhami P Dillon SC Dorschner MO Fiegler H Giresi PG Goldy J Hawrylycz M Haydock A Humbert R James KD Johnson BE Johnson EM Frum TT Rosenzweig ER Karnani N Lee K Lefebvre GC Navas PA Neri F Parker SC Sabo PJ 《Nature》2007,447(7146):799-816
20.