潜艇操纵运动的变结构控制

以潜艇操纵运动为对象，用变结构控制方法设计了一种潜艇空间运动的联合控制系统，其中水平面控制系统能对横摇运动施以主动控制，垂直面控制系统采用了自由递阶设计思想，可以有效地抑制运动耦合效应引起的干扰．系统仿真表明，所设计的控制系统动态品质良好，有较强的鲁棒性     

充液圆柱壳中的振动能量流

研究一无限长弹性薄壁充液圆柱壳的自由振动特性，获得了在不同周向波数时充水圆柱壳的频散曲线，讨论了此耦合系统自由振动时的传播波所对应的振动能量流，得出了各内力所传播的能量流之间的相对值     

燃烧室摄影图像计算机处理系统的探讨

提出了构造内燃机燃烧室摄影图像的计算机捕捉和处理系统，介绍了该系统的主要组成部分──帧捕捉器的软件开发，并对该系统和软件进行了评价，提出了进一步研究的方向。     

纵向加筋圆柱壳静动力性能分析

用壳条元和流体边界元统一分析了纵向加筋圆柱壳的静动力性能，利用Ｄ′Ａｌｅｍｂｅｒｔ原理和Ｈａｍｉｌｔｏｎ变分原理建立系统运动控制方程．对纵向加筋的布置形式及尺寸大小对于静动力性能的影响进行了系列的数值计算，得出了一些有价值的结论。     

柴油机涡轮增压方案的评选模型及其计算

基于模糊集理论和灰色关联分析，建立了柴油机涡轮增压系统的模糊关联度评选模型，该模型仿照人们评选柴油机涡轮增压系统性能优劣的过程，并考虑到评选过程中的模糊性，在单个评估指标的模糊评估基础上，利用灰色关联分析，综合分析与评估柴油机涡轮增压系统性能的优劣。示例说明应用这种评选新方法的具体步骤和需注意的问题，计算表明新方法是可行的。     

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

Uncoupling protein-3 (UCP-3) is a recently identified member of the mitochondrial transporter superfamily that is expressed predominantly in skeletal muscle. However, its close relative UCP-1 is expressed exclusively in brown adipose tissue, a tissue whose main function is fat combustion and thermogenesis. Studies on the expression of UCP-3 in animals and humans in different physiological situations support a role for UCP-3 in energy balance and lipid metabolism. However, direct evidence for these roles is lacking. Here we describe the creation of transgenic mice that overexpress human UCP-3 in skeletal muscle. These mice are hyperphagic but weigh less than their wild-type littermates. Magnetic resonance imaging shows a striking reduction in adipose tissue mass. The mice also exhibit lower fasting plasma glucose and insulin levels and an increased glucose clearance rate. This provides evidence that skeletal muscle UCP-3 has the potential to influence metabolic rate and glucose homeostasis in the whole animal.     

人类乙型肝炎样病毒核心蛋白中第7位疏水性氨基酸重复肚段区域的突变可以抑制病毒核衣壳的组装

人类乙型肝炎病毒的核衣壳由核心蛋白的二聚体所组成．但是,核心蛋白亚单位与亚单位之间相互作用的机制至今尚不清楚．研究发现,在人类乙型肝炎样病毒──土拨鼠肝炎病毒（WHV）核心蛋白的氨基端,存在着4个保守的疏水氨基酸残基（氨基酸位置101～102）．它们分别是亮氨酸101,亮氨酸108,缬氨酸115和苯丙氨酸122．这4个疏水氨基酸残基以每隔6个氨基酸残基而重复出现1次．它们被称为“第7位疏水性氨基酸重复肽段（hhr）”．由于蛋白质中的疏水键往往在蛋白质的相互作用中起重要作用,因此就在培养细胞系统中研究WHV核心蛋白的hhr区域在…     

Atypical beta-adrenoceptor on brown adipocytes as target for anti-obesity drugs

Recent studies suggest that thermogenesis in brown adipose tissue has an important role in the regulation of energy balance. Thermogenesis is effected by noradrenaline released from sympathetic nerve endings; the noradrenaline stimulates beta-adrenoceptors, causing lipolysis, and the released fatty acids then promote the uncoupling of oxidative phosphorylation from electron transport. It has been widely accepted that mammalian beta-adrenoceptors exist as two subtypes, beta 1 and beta 2, and rat brown adipocyte beta-adrenoceptors have been classed as beta 1 or as a mixed beta 1/beta 2 population. The beta 1 subtype predominates in atria, whereas the beta 2 subtype predominates in trachea. However, we have now found a novel group of beta-adrenoceptor agonists that selectively stimulate lipolysis in brown adipocytes. In contrast, isoprenaline, fenoterol and salbutamol are less potent as stimulants of lipolysis than as stimulants of atrial rate or tracheal relaxation. Therefore, beta-adrenoceptors in rat brown adipocytes are of neither the beta 1 nor beta 2 subtypes. Compounds that selectively stimulate brown adipocyte beta-adrenoceptors should have potential as thermogenic anti-obesity agents and this has been demonstrated with BRL 26830A , BRL 33725A and BRL 35135A .     

模件式脉冲转换系统三维流动的计算

阐述了用分形耦合贴体网格坐标和流体有限控制容积法，求解具有多分支、变曲率和变截面的复杂几何形状和边界条件的柴油机模件式脉冲转换系统中的非定常粘性可压三维流动计算问题，编制了计算程序进行计算．计算结果表明，这种计算方法对柴油机模件式脉冲转换系统的流动计算是相当有效的．其计算程序不仅可用于柴油机模件式脉冲转换系统，亦可用于脉冲系统和定压系统的流动计算，具有一定的通用性．     

用变系数微分方程进行船舶波浪弯矩的时域模拟

对船舶在波浪上的刚体运动理论加以改进，采用变系数微分方程对船舶在波浪上的运动进行模拟，并计算外力，计算表明，船舶在正弦波上的运动是一种近似于“拍”的运动，不是通常理论所假设的正弦周期运动，在微机上开发的程序能模拟各种规则波、非规则波输入时的船舶运动情况，为船舶结构可靠性分析中的外力随机分析奠定了基础。算例与文献进行了比较，表明了其正确性。