矿区植物--环境恢复的重要资源

综述了矿区植物的研究现状矿区植物的生态学、遗传学、植物分类学特性,矿区植物对重金属的耐性与吸收性,矿区植物在矿山及污染环境修复中的功能与作用;最后,探讨了矿区植物资源研究的未来发展方向。     

Natural variation for sulfate content in Arabidopsis thaliana is highly controlled by APR2

Most agronomic traits of importance, whether physiological (such as nutrient use efficiency) or developmental (such as flowering time), are controlled simultaneously by multiple genes and their interactions with the environment. Here, we show that variation in sulfate content between wild Arabidopsis thaliana accessions Bay-0 and Shahdara is controlled by a major quantitative trait locus that results in a strong interaction with nitrogen availability in the soil. Combining genetic and biochemical results and using a candidate gene approach, we have cloned the underlying gene, showing how a single-amino acid substitution in a key enzyme of the assimilatory sulfate reduction pathway, adenosine 5'-phosphosulfate reductase, is responsible for a decrease in enzyme activity, leading to sulfate accumulation in the plant. This work illustrates the potential of natural variation as a source of new alleles of known genes, which can aid in the study of gene function and metabolic pathway regulation. Our new insights on sulfate assimilation may have an impact on sulfur fertilizer use and stress defense improvement.     

Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL

Autosomal recessive osteopetrosis is usually associated with normal or elevated numbers of nonfunctional osteoclasts. Here we report mutations in the gene encoding RANKL (receptor activator of nuclear factor-KB ligand) in six individuals with autosomal recessive osteopetrosis whose bone biopsy specimens lacked osteoclasts. These individuals did not show any obvious defects in immunological parameters and could not be cured by hematopoietic stem cell transplantation; however, exogenous RANKL induced formation of functional osteoclasts from their monocytes, suggesting that they could, theoretically, benefit from exogenous RANKL administration.     

Helmholtz's Kant revisited (Once more). The all-pervasive nature of Helmholtz's struggle with Kant's Anschauung

In this analysis, the classical problem of Hermann von Helmholtz's (1821–1894) Kantianism is explored from a particular vantage point, that to my knowledge, has not received the attention it deserves notwithstanding its possible key role in disentangling Helmholtz's relation to Kant's critical project. More particularly, we will focus on Helmholtz's critical engagement with Kant's concept of intuition [Anschauung] and (the related issue of) his dissatisfaction with Kant's doctrinal dualism. In doing so, it soon becomes clear that both (i) crucially mediated Helmholtz's idiosyncratic appropriation and criticism of (certain aspects of) Kant's critical project, and (ii) can be considered as a common denominator in a variety of issues that are usually addressed separately under the general header of (the problem of) Helmholtz's Kantianism. The perspective offered in this analysis can not only shed interesting new light on some interpretive issues that have become commonplace in discussions on Helmholtz's Kantianism, but also offers a particular way of connecting seemingly unrelated dimensions of Helmholtz's engagement with Kant's critical project (e.g. Helmholtz's views on causality and space). Furthermore, it amounts to the rather surprising conclusion that Helmholtz's most drastic revision of Kant's project pertains to his assumption of free will as a formal condition of experience and knowledge.     

The growth plate’s response to load is partially mediated by mechano-sensing via the chondrocytic primary cilium

Mechanical load plays a significant role in bone and growth-plate development. Chondrocytes sense and respond to mechanical stimulation; however, the mechanisms by which those signals exert their effects are not fully understood. The primary cilium has been identified as a mechano-sensor in several cell types, including renal epithelial cells and endothelium, and accumulating evidence connects it to mechano-transduction in chondrocytes. In the growth plate, the primary cilium is involved in several regulatory pathways, such as the non-canonical Wnt and Indian Hedgehog. Moreover, it mediates cell shape, orientation, growth, and differentiation in the growth plate. In this work, we show that mechanical load enhances ciliogenesis in the growth plate. This leads to alterations in the expression and localization of key members of the Ihh-PTHrP loop resulting in decreased proliferation and an abnormal switch from proliferation to differentiation, together with abnormal chondrocyte morphology and organization. Moreover, we use the chondrogenic cell line ATDC5, a model for growth-plate chondrocytes, to understand the mechanisms mediating the participation of the primary cilium, and in particular KIF3A, in the cell’s response to mechanical stimulation. We show that this key component of the cilium mediates gene expression in response to mechanical stimulation.     

职住变迁与通勤自平衡

采用2011年和2014年各两周的上海移动手机信令数据,通过跟踪分析识别出居住地、就业地发生变迁的居民作为研究对象,数据可视化、描述性统计、定量对比分析等方法对同一批变迁居民的通勤行为进行跟踪研究,以此对其中存在的“自平衡”特征进行分析,并进一步研究该变化特征与城市空间之间所存在的联系。研究表明：总体层面,从平均通勤距离变化以及过剩通勤率变化方面来看,居民在进行居住地、就业地变迁时均存在通勤“自平衡”的特征与趋势;个体层面,原通勤距离越远,通过居住地、就业地变迁以改善自身通勤关系追求通勤“自平衡”的效果越明显;就业地变迁居民的通勤“自平衡”特征相较于居住地变迁来说更加显著;空间集合层面,职住关系较差的居住区、就业区,存在总体的“自平衡”现象。     

传递矩阵方法与矩形势垒的量子隧穿

利用传递矩阵方法精确计算了一维定态薛定谔方程,求解出电子穿过矩形势垒的透射系数,进一步研究了该透射系数与有效质量和矩形势垒参数的关系。数值计算结果表明,有效质量和矩形势垒参数对透射系数的影响同等重要。     

钱家营矿选煤厂重选方案优化

在对钱家营矿原煤特性分析的基础上,利用选煤优化软件进行计算机优化,得出钱家营矿选煤厂重力分选最佳方案:各层煤单独分选出不同的精煤产品或采用选后配煤的方法将单独分选出的产品混合,以获得用户要求的产品.该方案比混合分选或混合后分级入选精煤产率高,可为选煤厂带来更好的经济效益.     

玉米秸秆纤维复合缓冲包装材料的研究

研究了以聚醚多元醇、聚异氰酸酯为基体,以玉米秸秆纤维为增强体的新型复合缓冲包装材料,通过控制玉米秸秆纤维的添加量、发泡剂用量、交联剂与催化剂用量、反应温度等工艺参数,实验制备了具有可降解性能的缓冲包装材料,并利用静态压缩实验方法对比了该材料与发泡聚苯乙烯的缓冲性能.