全文获取类型
收费全文 | 57篇 |
免费 | 0篇 |
专业分类
系统科学 | 2篇 |
现状及发展 | 25篇 |
研究方法 | 5篇 |
综合类 | 25篇 |
出版年
2018年 | 2篇 |
2016年 | 1篇 |
2011年 | 2篇 |
2010年 | 2篇 |
2008年 | 2篇 |
2007年 | 2篇 |
2006年 | 3篇 |
2005年 | 1篇 |
2004年 | 1篇 |
2003年 | 2篇 |
2001年 | 2篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 3篇 |
1973年 | 4篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1970年 | 3篇 |
1969年 | 1篇 |
1968年 | 2篇 |
1967年 | 4篇 |
1966年 | 1篇 |
1965年 | 5篇 |
1964年 | 1篇 |
1963年 | 2篇 |
1959年 | 1篇 |
1954年 | 1篇 |
排序方式: 共有57条查询结果,搜索用时 15 毫秒
41.
42.
43.
44.
45.
Gentamicin and tobramycin are important antibiotics in the treatment of hospital infections because of their activity against a wide range of bacterial genera. With their increasing use, bacteria resistant to these drugs have appeared, the resistance being frequently plasmid determined. The resistance genes determine various enzymes that modify and inactivate the drugs and there is association between particular gentamicin/tobramycin resistance genes and plasmids of particular groups, implying that acquisition of such a gene by any plasmid is a rare event. We now report the identification of a transposon or 'jumping gene' encoding the gentamicin/tobramycin adenylylating enzyme, ANT(2"), on a plasmid of incompatiblity group FII (IncFII). 相似文献
46.
The Hedgehog family of growth factors activate a highly conserved signaling system for cell-cell communication that regulates
cell proliferation and differentiation during development. Abnormal activation of the Hedgehog pathway has been demonstrated
in a variety of human tumors, including those of the skin, brain, lung and digestive tract. Hedgehog pathway activity in these
tumors is required for cancer cell proliferation and tumor growth. Recent studies have uncovered the role for Hedgehog signaling
in advanced prostate cancer and demonstrated that autocrine signaling by tumor cells is required for proliferation, viability,
and invasive behavior. The level of Hedgehog activity correlates with the severity of the tumor and is both necessary and
sufficient for metastatic behavior. Blockade of Hedgehog signaling leads to tumor shrinkage and remission in preclinical tumor
xenograft models. Thus, Hedgehog signaling represents a novel pathway in prostate cancer that offers opportunities for prognostic
biomarker development, drug targeting and therapeutic response monitoring.
Received 18 August 2005; received after revision 30 September 2005; accepted 1 November 2005 相似文献
47.
Rioux JD Xavier RJ Taylor KD Silverberg MS Goyette P Huett A Green T Kuballa P Barmada MM Datta LW Shugart YY Griffiths AM Targan SR Ippoliti AF Bernard EJ Mei L Nicolae DL Regueiro M Schumm LP Steinhart AH Rotter JI Duerr RH Cho JH Daly MJ Brant SR 《Nature genetics》2007,39(5):596-604
We present a genome-wide association study of ileal Crohn disease and two independent replication studies that identify several new regions of association to Crohn disease. Specifically, in addition to the previously established CARD15 and IL23R associations, we identified strong and significantly replicated associations (combined P < 10(-10)) with an intergenic region on 10q21.1 and a coding variant in ATG16L1, the latter of which was also recently reported by another group. We also report strong associations with independent replication to variation in the genomic regions encoding PHOX2B, NCF4 and a predicted gene on 16q24.1 (FAM92B). Finally, we demonstrate that ATG16L1 is expressed in intestinal epithelial cell lines and that functional knockdown of this gene abrogates autophagy of Salmonella typhimurium. Together, these findings suggest that autophagy and host cell responses to intracellular microbes are involved in the pathogenesis of Crohn disease. 相似文献
48.
Genome-wide atlas of gene expression in the adult mouse brain 总被引:1,自引:0,他引:1
Lein ES Hawrylycz MJ Ao N Ayres M Bensinger A Bernard A Boe AF Boguski MS Brockway KS Byrnes EJ Chen L Chen L Chen TM Chin MC Chong J Crook BE Czaplinska A Dang CN Datta S Dee NR Desaki AL Desta T Diep E Dolbeare TA Donelan MJ Dong HW Dougherty JG Duncan BJ Ebbert AJ Eichele G Estin LK Faber C Facer BA Fields R Fischer SR Fliss TP Frensley C Gates SN Glattfelder KJ Halverson KR Hart MR Hohmann JG Howell MP Jeung DP Johnson RA Karr PT Kawal R Kidney JM Knapik RH Kuan CL Lake JH Laramee AR 《Nature》2007,445(7124):168-176
Molecular approaches to understanding the functional circuitry of the nervous system promise new insights into the relationship between genes, brain and behaviour. The cellular diversity of the brain necessitates a cellular resolution approach towards understanding the functional genomics of the nervous system. We describe here an anatomically comprehensive digital atlas containing the expression patterns of approximately 20,000 genes in the adult mouse brain. Data were generated using automated high-throughput procedures for in situ hybridization and data acquisition, and are publicly accessible online. Newly developed image-based informatics tools allow global genome-scale structural analysis and cross-correlation, as well as identification of regionally enriched genes. Unbiased fine-resolution analysis has identified highly specific cellular markers as well as extensive evidence of cellular heterogeneity not evident in classical neuroanatomical atlases. This highly standardized atlas provides an open, primary data resource for a wide variety of further studies concerning brain organization and function. 相似文献
49.
50.