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41.
E. Del Conte 《Cellular and molecular life sciences : CMLS》1972,28(4):451-453
Resumen El estudio histofisiológico de la glándula interrenal de un lagarto teído (Cnemidophorus l. lemniscatus) permitió poner de manifiesto la que se denominó zona reactiva de la glándula. Por su situación es periférica, y está constituida por células dispuestas en formaciones redondeadas. Estas células, que tienen normalmente aspecto de menor actividad, responden más rápida e intensamente que las centrales a la acción de la corticotrofina, exógena o endógena, y aparecen entonces más activas que las últimas. 相似文献
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E. Del Conte 《Cellular and molecular life sciences : CMLS》1969,25(12):1330-1332
Resumen Mediante la administration de metopirona pudo demostrarse en la hipófisis anterior deCnemidophorus l. lemniscatus la existencia de un tercer tipo de células secretoras no mucoprotidicas, responsables de la producción de corticotrofina y no identificadas hasta ahora en reptiles. Estas células se encuentran en la portión rostral del lóbulo y, en los animales testigos, resultan cromófobas con las coloraciones efectuadas. Por acción de la metopirona sufren considerable hipertrofia e hiperplasia y aparecen en su citoplasma gránulos gruesos y relativamente escasos que presentan moderada afinidad hacia la hematoxilina férrica. 相似文献
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Seo MD Velamakanni S Ishiyama N Stathopulos PB Rossi AM Khan SA Dale P Li C Ames JB Ikura M Taylor CW 《Nature》2012,483(7387):108-112
Inositol-1,4,5-trisphosphate receptors (InsP(3)Rs) and ryanodine receptors (RyRs) are tetrameric intracellular Ca(2+) channels. In each of these receptor families, the pore, which is formed by carboxy-terminal transmembrane domains, is regulated by signals that are detected by large cytosolic structures. InsP(3)R gating is initiated by InsP(3) binding to the InsP(3)-binding core (IBC, residues 224-604 of InsP(3)R1) and it requires the suppressor domain (SD, residues 1-223 of InsP(3)R1). Here we present structures of the amino-terminal region (NT, residues 1-604) of rat InsP(3)R1 with (3.6??) and without (3.0??) InsP(3) bound. The arrangement of the three NT domains, SD, IBC-β and IBC-α, identifies two discrete interfaces (α and β) between the IBC and SD. Similar interfaces occur between equivalent domains (A, B and C) in RyR1 (ref. 9). The orientations of the three domains when docked into a tetrameric structure of InsP(3)R and of the ABC domains docked into RyR are remarkably similar. The importance of the α-interface for activation of InsP(3)R and RyR is confirmed by mutagenesis and, for RyR, by disease-causing mutations. Binding of InsP(3) causes partial closure of the clam-like IBC, disrupting the β-interface and pulling the SD towards the IBC. This reorients an exposed SD loop ('hotspot' (HS) loop) that is essential for InsP(3)R activation. The loop is conserved in RyR and includes mutations that are associated with malignant hyperthermia and central core disease. The HS loop interacts with an adjacent NT, suggesting that activation re-arranges inter-subunit interactions. The A domain of RyR functionally replaced the SD in full-length InsP(3)R, and an InsP(3)R in which its C-terminal transmembrane region was replaced by that from RyR1 was gated by InsP(3) and blocked by ryanodine. Activation mechanisms are conserved between InsP(3)R and RyR. Allosteric modulation of two similar domain interfaces within an N-terminal subunit reorients the first domain (SD or A domain), allowing it, through interactions of the second domain of an adjacent subunit (IBC-β or B domain), to gate the pore. 相似文献
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Cristian Pérez-Granados Karl-L. Schuchmann Todor Ganchev Christine Strüssmann Tainá Figueras Dorado-Rodrigues Ana Silvia de Oliveira Tissiani 《Journal of Natural History》2019,53(43-44):2699-2710
ABSTRACTAcoustic monitoring provides the opportunity to study ecological processes that are difficult to assess with traditional surveys. Elachistocleis matogrosso is an anuran species, described in 2010, for which limited biological information is available. This study investigated the calling activity of the species in the north-eastern portion of the Pantanal, Brazil, a wetland area with marked seasonality between the dry and wet seasons. The calling activity of E. matogrosso was monitored using automated digital recorders in combination with automated signal recognition software over two different annual cycles. The species was vocally active only during the wet season (October – April), with a peak in November-December during the 2013–2014 annual cycle and in February-March during the 2015–2016 annual cycle. The peak calling activity occurred at dusk. This species has nocturnal habits and an explosive breeding activity. The detection of the species was intermittent, which suggests that environmental predictors or site-specific conditions might play an important role in species detection. Moreover, this intermittent occupancy indicated that surveys that employ traditional field techniques would likely fail to detect this species. We describe an effective protocol for detecting E. matogrosso with acoustic monitoring, which requires recording during 20 days in February from 17:01 to 05:00. Our procedure would be easy to adapt to other anuran species, and it could be used for investigating new localities and assessing population changes over time. 相似文献